View source for (Phosphatase 2A protein)-leucine-carboxy methyltransferase

{{Short description|Class of enzymes}}
{{Infobox enzyme
| Name       = (phosphatase 2A protein)-leucine-carboxy methyltransferase
| EC_number  = 2.1.1.233
| CAS_number =
| GO_code    =
| image      =
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}}
'''(phosphatase 2A protein)-leucine-carboxy methyltransferase''' ({{EC number|2.1.1.233}}, ''leucine carboxy methyltransferase-1'', ''LCMT1'') is an [[enzyme]] with [[List of enzymes|systematic name]] ''S-adenosyl-L-methionine:(phosphatase 2A protein)-leucine O-methyltransferase''.<ref>{{cite journal | vauthors = De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J | title = Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue | journal = Biochemistry | volume = 38 | issue = 50 | pages = 16539–47 | date = December 1999 | pmid = 10600115 | doi = 10.1021/bi991646a }}</ref><ref>{{cite journal | vauthors = Tsai ML, Cronin N, Djordjevic S | title = The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A | journal = Acta Crystallographica Section D | volume = 67 | issue = Pt 1 | pages = 14–24 | date = January 2011 | pmid = 21206058 | doi = 10.1107/s0907444910042204 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
: [[S-adenosyl-L-methionine|''S''-adenosyl-<small>L</small>-methionine]] + [phosphatase 2A protein]-leucine <math>\rightleftharpoons</math> [[S-adenosyl-L-homocysteine|''S''-adenosyl-<small>L</small>-homocysteine]] + [phosphatase 2A protein]-leucine methyl ester
Methylates the [[C-terminal]] [[leucine]] of [[Protein phosphatase 2|phosphatase 2A]].
== References ==
{{reflist}}
== External links ==
* {{MeshName|(phosphatase+2A+protein)-leucine-carboxy+methyltransferase}}
{{One carbon transferases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
[[Category:EC 2.1.1]]