View source for ADP-dependent NAD(P)H-hydrate dehydratase

{{Infobox enzyme
| Name       = ADP-dependent NAD(P)H-hydrate dehydratase
| EC_number  = 4.2.1.136
| CAS_number =
| GO_code    =
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'''ADP-dependent NAD(P)H-hydrate dehydratase''' ({{EnzExplorer|4.2.1.136}}, ''(6''S'')-β-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing)'', ''(6S)-6-β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing, NADH-forming)'') is an [[enzyme]] with [[List of enzymes|systematic name]] ''(6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing; NADH-forming)''.<ref>{{cite journal | vauthors = Marbaix AY, Noël G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL | title = Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair | journal = The Journal of Biological Chemistry | volume = 286 | issue = 48 | pages = 41246–52 | date = December 2011 | pmid = 21994945 | pmc = 3308837 | doi = 10.1074/jbc.c111.310847 | doi-access = free }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
: (1) ADP + (6''S'')-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide <math>\rightleftharpoons</math> AMP + [[phosphate]] + NADH
: (2) ADP + (6''S'')-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate <math>\rightleftharpoons</math> AMP + phosphate + NADPH
This enzyme acts equally well on hydrated NADH and hydrated NADPH.
== References ==
{{reflist}}
== External links ==
* {{MeshName|ADP-dependent+NAD(P)H-hydrate+dehydratase}}
{{Carbon-oxygen lyases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
[[Category:EC 4.2.1]]