View source for ARPC1B

{{Short description|Mammalian protein found in Homo sapiens}}
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{{Infobox_gene}}
'''Actin-related protein 2/3 complex subunit 1B''' is a [[protein]] that in humans is encoded by the ''ARPC1B'' [[gene]].<ref name="pmid9230079">{{cite journal | vauthors = Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ | title = The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly | journal = The Journal of Cell Biology | volume = 138 | issue = 2 | pages = 375–384 | date = July 1997 | pmid = 9230079 | pmc = 2138188 | doi = 10.1083/jcb.138.2.375 }}</ref><ref name="pmid9359840">{{cite journal | vauthors = Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW | title = Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins | journal = The Biochemical Journal | volume = 328 | issue = Pt 1 | pages = 105–112 | date = November 1997 | pmid = 9359840 | pmc = 1218893 | doi = 10.1042/bj3280105 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10095| access-date = }}</ref>
== Function ==
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that facilitates branching of actin filaments in cells. Isoforms of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages.<ref name="entrez"/>  Indeed, it has recently been shown that variants of the Arp2/3 complex differ in their ability to promote actin assembly, with  complexes containing ARPC1B and ARPC5L being better at this than those containing ARPC1A and ARPC5.<ref>{{cite journal | vauthors = Abella JV, Galloni C, Pernier J, Barry DJ, Kjær S, Carlier MF, Way M | title = Isoform diversity in the Arp2/3 complex determines actin filament dynamics | journal = Nature Cell Biology | volume = 18 | issue = 1 | pages = 76–86 | date = January 2016 | pmid = 26655834 | doi = 10.1038/ncb3286 | s2cid = 2916212 }}</ref> The differing functions of ARPC1A and ARPC1B are also evident in the recent discovery of patients with severe or total ARPC1B deficiency, who have platelet and immune system abnormalities yet survive, possibly due to a compensatory up-regulation of ARPC1A expression.<ref>{{cite journal | vauthors = Kahr WH, Pluthero FG, Elkadri A, Warner N, Drobac M, Chen CH, Lo RW, Li L, Li R, Li Q, Thoeni C, Pan J, Leung G, Lara-Corrales I, Murchie R, Cutz E, Laxer RM, Upton J, Roifman CM, Yeung RS, Brumell JH, Muise AM | title = Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease | journal = Nature Communications | volume = 8 | pages = 14816 | date = April 2017 | pmid = 28368018 | pmc = 5382316 | doi = 10.1038/ncomms14816 | bibcode = 2017NatCo...814816K }}</ref>
== Interactions ==
ARPC1B has been shown to [[Protein-protein interaction|interact]] with [[PAK1]].<ref name=pmid14749719>{{cite journal | vauthors = Vadlamudi RK, Li F, Barnes CJ, Bagheri-Yarmand R, Kumar R | title = p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate | journal = EMBO Reports | volume = 5 | issue = 2 | pages = 154–160 | date = February 2004 | pmid = 14749719 | pmc = 1298990 | doi = 10.1038/sj.embor.7400079 }}</ref>
== References ==
{{reflist}}
== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–113 | date = April 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Welch MD, Iwamatsu A, Mitchison TJ | title = Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes | journal = Nature | volume = 385 | issue = 6613 | pages = 265–269 | date = January 1997 | pmid = 9000076 | doi = 10.1038/385265a0 | s2cid = 4358529 | bibcode = 1997Natur.385..265W }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–358 | date = April 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
* {{cite journal | vauthors = Rassenti LZ, Kipps TJ | title = Lack of allelic exclusion in B cell chronic lymphocytic leukemia | journal = The Journal of Experimental Medicine | volume = 185 | issue = 8 | pages = 1435–1445 | date = April 1997 | pmid = 9126924 | pmc = 2196272 | doi = 10.1084/jem.185.8.1435 }}
* {{cite journal | vauthors = Zhao X, Yang Z, Qian M, Zhu X | title = Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub | journal = Biochemical and Biophysical Research Communications | volume = 280 | issue = 2 | pages = 513–517 | date = January 2001 | pmid = 11162547 | doi = 10.1006/bbrc.2000.4151 }}
* {{cite journal | vauthors = Volkmann N, Amann KJ, Stoilova-McPhie S, Egile C, Winter DC, Hazelwood L, Heuser JE, Li R, Pollard TD, Hanein D | title = Structure of Arp2/3 complex in its activated state and in actin filament branch junctions | journal = Science | volume = 293 | issue = 5539 | pages = 2456–2459 | date = September 2001 | pmid = 11533442 | doi = 10.1126/science.1063025 | s2cid = 17427295 | doi-access = free | bibcode = 2001Sci...293.2456V }}
* {{cite journal | vauthors = Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD | title = Crystal structure of Arp2/3 complex | journal = Science | volume = 294 | issue = 5547 | pages = 1679–1684 | date = November 2001 | pmid = 11721045 | doi = 10.1126/science.1066333 | s2cid = 18088124 | bibcode = 2001Sci...294.1679R }}
* {{cite journal | vauthors = Gournier H, Goley ED, Niederstrasser H, Trinh T, Welch MD | title = Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity | journal = Molecular Cell | volume = 8 | issue = 5 | pages = 1041–1052 | date = November 2001 | pmid = 11741539 | doi = 10.1016/S1097-2765(01)00393-8 | doi-access = free }}
* {{cite journal | vauthors = Hüfner K, Schell B, Aepfelbacher M, Linder S | title = The acidic regions of WASp and N-WASP can synergize with CDC42Hs and Rac1 to induce filopodia and lamellipodia | journal = FEBS Letters | volume = 514 | issue = 2–3 | pages = 168–174 | date = March 2002 | pmid = 11943145 | doi = 10.1016/S0014-5793(02)02358-X | s2cid = 36684487 | doi-access = free | bibcode = 2002FEBSL.514..168H }}
* {{cite journal | vauthors = Kaneda A, Kaminishi M, Nakanishi Y, Sugimura T, Ushijima T | title = Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers | journal = International Journal of Cancer | volume = 100 | issue = 1 | pages = 57–62 | date = July 2002 | pmid = 12115587 | doi = 10.1002/ijc.10464 | s2cid = 13737339 | doi-access = free }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nature Biotechnology | volume = 21 | issue = 5 | pages = 566–569 | date = May 2003 | pmid = 12665801 | doi = 10.1038/nbt810 | s2cid = 23783563 }}
* {{cite journal | vauthors = Vadlamudi RK, Li F, Barnes CJ, Bagheri-Yarmand R, Kumar R | title = p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate | journal = EMBO Reports | volume = 5 | issue = 2 | pages = 154–160 | date = February 2004 | pmid = 14749719 | pmc = 1298990 | doi = 10.1038/sj.embor.7400079 }}
* {{cite journal | vauthors = Kaneda A, Kaminishi M, Sugimura T, Ushijima T | title = Decreased expression of the seven ARP2/3 complex genes in human gastric cancers | journal = Cancer Letters | volume = 212 | issue = 2 | pages = 203–210 | date = August 2004 | pmid = 15279900 | doi = 10.1016/j.canlet.2004.03.020 }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = January 2005 | pmid = 15635413 | doi = 10.1038/nature03207 | s2cid = 4344740 | bibcode = 2005Natur.433...77A }}
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== External links ==
* {{UCSC genome browser|ARPC1B}}
* {{UCSC gene details|ARPC1B}}
* {{PDBe-KB2|Q58CQ2|Bovine Actin-related protein 2/3 complex subunit 1B}}
{{PDB Gallery|geneid=10095}}
{{protein-stub}}