View source for BMF (gene)

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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Bcl-2-modifying factor''' is a [[protein]] that in humans is encoded by the ''BMF'' [[gene]].<ref name="pmid11546872">{{cite journal | vauthors = Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC, Strasser A | title = Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis | journal = Science | volume = 293 | issue = 5536 | pages = 1829–32 |date=Sep 2001 | pmid = 11546872 | doi = 10.1126/science.1062257 | bibcode = 2001Sci...293.1829P | s2cid = 5638023 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BMF Bcl2 modifying factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90427}}</ref>
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: BMF Bcl2 modifying factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90427}}</ref>
==Interactions==
BMF (gene) has been shown to [[Protein-protein interaction|interact]] with [[Bcl-2]]<ref name=pmid11546872 /> and [[DYNLL2]].<ref name=pmid11546872/><ref name=pmid14561217>{{cite journal |last=Day |first=Catherine L |author2=Puthalakath Hamsa|author3=Skea Gretchen|author4=Strasser Andreas|author5=Barsukov Igor|author6=Lian Lu-Yun|author7=Huang David C S|author8=Hinds Mark G |date=Feb 2004 |title=Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands |journal=Biochem. J. |volume=377 |issue=Pt 3 |pages=597–605 |location = England| pmid = 14561217 |doi = 10.1042/BJ20031251 |pmc=1223895 }}</ref>
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Hattori A, Okumura K, Nagase T |title=Characterization of long cDNA clones from human adult spleen. |journal=DNA Res. |volume=7 |issue= 6 |pages= 357–66 |year= 2001 |pmid= 11214971 |doi=10.1093/dnares/7.6.357  |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Lei K, Davis RJ |title=JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2432–7 |year= 2003 |pmid= 12591950 |doi= 10.1073/pnas.0438011100  | pmc=151358 |bibcode=2003PNAS..100.2432L |doi-access=free }}
*{{cite journal  | vauthors=Day CL, Puthalakath H, Skea G |title=Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. |journal=Biochem. J. |volume=377 |issue= Pt 3 |pages= 597–605 |year= 2004 |pmid= 14561217 |doi= 10.1042/BJ20031251  | pmc=1223895 |display-authors=etal}}
*{{cite journal  | vauthors=Morales AA, Olsson A, Celsing F |title=Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells. |journal=Leukemia |volume=18 |issue= 1 |pages= 41–7 |year= 2004 |pmid= 14574334 |doi= 10.1038/sj.leu.2403183 |display-authors=etal|doi-access= |s2cid=23083926 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Chen L, Willis SN, Wei A |title=Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. |journal=Mol. Cell |volume=17 |issue= 3 |pages= 393–403 |year= 2005 |pmid= 15694340 |doi= 10.1016/j.molcel.2004.12.030 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Kuwana T, Bouchier-Hayes L, Chipuk JE |title=BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. |journal=Mol. Cell |volume=17 |issue= 4 |pages= 525–35 |year= 2005 |pmid= 15721256 |doi= 10.1016/j.molcel.2005.02.003 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Soung YH, Lee JW, Park WS |title=BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder. |journal=Pathology |volume=38 |issue= 1 |pages= 33–4 |year= 2006 |pmid= 16484005 |doi= 10.1080/00313020500455811 |s2cid=32022854 |display-authors=etal}}
*{{cite journal  | vauthors=Zhang Y, Adachi M, Kawamura R |title=Bmf contributes to histone deacetylase inhibitor-mediated enhancing effects on apoptosis after ionizing radiation. |journal=Apoptosis |volume=11 |issue= 8 |pages= 1349–57 |year= 2007 |pmid= 16830229 |doi= 10.1007/s10495-006-8266-1 |s2cid=19085805 |display-authors=etal}}
*{{cite journal  | vauthors=Schmelzle T, Mailleux AA, Overholtzer M |title=Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 10 |pages= 3787–92 |year= 2007 |pmid= 17360431 |doi= 10.1073/pnas.0700115104  | pmc=1820662 |bibcode=2007PNAS..104.3787S |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Yoo NJ, Soung YH, Lee SH |title=Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas. |journal=Tumori |volume=93 |issue= 2 |pages= 195–7 |year= 2007 |doi=10.1177/030089160709300214 |pmid= 17557568 |s2cid=21247583 |display-authors=etal}}
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==External links==
* {{UCSC gene info|BMF}}
{{gene-15-stub}}