View source for Bombinin

{{Infobox protein family
| Symbol = Bombinin
| Name = Bombinin
| image =
| width =
| caption = solution structure of bombinin h2 in dpc micelles
| Pfam = PF05298
| Pfam_clan =
| InterPro = IPR007962
| SMART =
| PROSITE =
| MEROPS =
| SCOP =
| TCDB =
| OPM family = 211
| OPM protein = 2ap8
| CAZy =
| CDD =
}}
The '''bombinin''' family of [[antimicrobial]] [[peptides]] includes the bombinin and maximin [[protein]]s from ''[[Bombina maxima]]'' (Giant fire-bellied toad). Two groups of [[antimicrobial peptide]]s have been isolated from skin [[secretion]]s of ''B. maxima''. Peptides in the first group, named maximins 1, 2, 3, 4 and 5, are [[structurally]] related to bombinin-like peptides (BLPs). Unlike BLPs, sequence variations in maximins occurred all through the [[molecule]]s. In addition to the potent antimicrobial activity, cytotoxicity against [[tumour]] [[cell (biology)|cell]]s and spermicidal action of maximins, maximin 3 possessed a significant anti-Simian-[[HIV|Human immunodeficiency virus]] (HIV) activity. Maximins 1 and 3 have been found to be [[toxic]] to [[mice]]. Peptides in the second group, termed maximins H1, H2, H3 and H4, are [[Homology (biology)|homologous]] with bombinin H peptides.<ref name="pmid11835991">{{cite journal |vauthors=Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y | title = Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima | journal = Peptides | volume = 23 | issue = 3 | pages = 427–435 |date=March 2002 | pmid = 11835991 | doi = 10.1016/S0196-9781(01)00641-6| s2cid = 1421665 }}</ref>
==References==
{{reflist}}
{{InterPro content|IPR007962}}
[[Category:Protein families]]
[[Category:Antimicrobial peptides]]