View source for CAMK1

{{cs1 config|name-list-style=vanc}}
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
'''Calcium/calmodulin-dependent protein kinase type 1''' is an [[enzyme]] that in humans is encoded by the ''CAMK1'' [[gene]].<ref name="pmid7641687">{{cite journal | vauthors = Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR | title = Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase | journal = EMBO J | volume = 14 | issue = 15 | pages = 3679–86 |date=Sep 1995 | pmid = 7641687 | pmc = 394442 | doi =  10.1002/j.1460-2075.1995.tb00037.x}}</ref><ref name="entrez"/>
Calcium/calmodulin-dependent [[protein kinase]] I is [[gene expression|expressed]] in many [[tissue (biology)|tissues]] and is a component of a [[calmodulin]]-dependent protein kinase cascade.  Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the [[phosphorylation]] and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.<ref name="entrez">{{cite web | title = Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8536}}</ref>
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Bredt DS, Ferris CD, Snyder SH |title=Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 10976–81 |year= 1992 |doi=10.1016/S0021-9258(19)49862-1 |pmid= 1375933 |doi-access=free }}
*{{cite journal  | vauthors=Yokokura H, Picciotto MR, Nairn AC, Hidaka H |title=The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains |journal=J. Biol. Chem. |volume=270 |issue= 40 |pages= 23851–9 |year= 1995 |pmid= 7559563 |doi=10.1074/jbc.270.40.23851  |doi-access=free }}
*{{cite journal  | vauthors=Liu F, Thompson MA, Wagner S |title=Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6714–20 |year= 1993 |doi=10.1016/S0021-9258(18)53308-1 |pmid= 8384217 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Chin D, Winkler KE, Means AR |title=Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31235–40 |year= 1998 |pmid= 9395448 |doi=10.1074/jbc.272.50.31235  |doi-access=free }}
*{{cite journal  | vauthors=Hsu LS, Tsou AP, Chi CW |title=Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase |journal=J. Biomed. Sci. |volume=5 |issue= 2 |pages= 141–9 |year= 1998 |pmid= 9662074 |doi=  10.1007/bf02258368|display-authors=etal}}
*{{cite journal  | vauthors=Matsushita M, Nairn AC |title=Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21473–81 |year= 1998 |pmid= 9705275 |doi=10.1074/jbc.273.34.21473  |doi-access=free }}
*{{cite journal  | vauthors=Anderson KA, Means RL, Huang QH |title=Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31880–9 |year= 1998 |pmid= 9822657 |doi=10.1074/jbc.273.48.31880  |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Matsushita M, Nairn AC |title=Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10086–93 |year= 1999 |pmid= 10187789 |doi=10.1074/jbc.274.15.10086  |doi-access=free }}
*{{cite journal  | vauthors=Hayashi Y, Nishio M, Naito Y |title=Regulation of neuronal nitric-oxide synthase by calmodulin kinases |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20597–602 |year= 1999 |pmid= 10400690 |doi=10.1074/jbc.274.29.20597  |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Hosaka M, Hammer RE, Südhof TC |title=A phospho-switch controls the dynamic association of synapsins with synaptic vesicles |journal=Neuron |volume=24 |issue= 2 |pages= 377–87 |year= 1999 |pmid= 10571231 |doi=10.1016/S0896-6273(00)80851-X  |s2cid=14103027 |doi-access=free }}
*{{cite journal  | vauthors=Komeima K, Hayashi Y, Naito Y, Watanabe Y |title=Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28139–43 |year= 2000 |pmid= 10874031 |doi= 10.1074/jbc.M003198200 |doi-access= free }}
*{{cite journal  | vauthors=McKinsey TA, Zhang CL, Lu J, Olson EN |title=Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation |journal=Nature |volume=408 |issue= 6808 |pages= 106–11 |year= 2000 |pmid= 11081517 |doi= 10.1038/35040593 |pmc=4459600 |bibcode=2000Natur.408..106M }}
*{{cite journal  | vauthors=McKinsey TA, Zhang CL, Olson EN |title=Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14400–5 |year= 2001 |pmid= 11114197 |doi= 10.1073/pnas.260501497  | pmc=18930 |bibcode=2000PNAS...9714400M |doi-access=free }}
*{{cite journal  | vauthors=Hsu LS, Chen GD, Lee LS |title=Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31113–23 |year= 2001 |pmid= 11395482 |doi= 10.1074/jbc.M011720200 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Condon JC, Pezzi V, Drummond BM |title=Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase |journal=Endocrinology |volume=143 |issue= 9 |pages= 3651–7 |year= 2002 |pmid= 12193581 |doi=10.1210/en.2001-211359  |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Sakurada K, Kato H, Nagumo H |title=Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45473–9 |year= 2003 |pmid= 12237306 |doi= 10.1074/jbc.M206673200 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Clapperton JA, Martin SR, Smerdon SJ |title=Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism |journal=Biochemistry |volume=41 |issue= 50 |pages= 14669–79 |year= 2003 |pmid= 12475216 |doi=10.1021/bi026660t  |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Izmailova E, Bertley FM, Huang Q |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 |s2cid=26145639 |display-authors=etal}}
{{refend}}
==External links==
* {{UCSC gene info|CAMK1}}
{{PDB Gallery|geneid=8536}}
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
[[Category:EC 2.7.11]]
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