View source for CAMK2G

{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
'''Calcium/calmodulin-dependent protein kinase type II gamma chain''' is an [[enzyme]] that in humans is encoded by the ''CAMK2G'' [[gene]].<ref name="pmid8287681">{{cite journal | vauthors = Li X, Nghiem P, Schulman H, Francke U | title = Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14 | journal = Cytogenet Cell Genet | volume = 66 | issue = 2 | pages = 113–6 | date = Feb 1994 | pmid = 8287681 | doi = 10.1159/000133679 | s2cid = 46836396 }}</ref>
== Function ==
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined.<ref>{{cite web | title = Entrez Gene: CAMK2G calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=818}}</ref>
== Interactions ==
CAMK2G has been shown to [[Protein-protein interaction|interact]] with [[RRAD (gene)|RRAD]].<ref name=pmid9115241>{{cite journal | vauthors = Moyers JS, Bilan PJ, Zhu J, Kahn CR | title = Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II | journal = J. Biol. Chem. | volume = 272 | issue = 18 | pages = 11832–9 | date = May 1997 | pmid = 9115241 | doi = 10.1074/jbc.272.18.11832 | doi-access = free }}</ref>
== See also ==
* [[Ca2+/calmodulin-dependent protein kinase]]
== References ==
{{reflist}}
== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Hook SS, Means AR | title = Ca(2+)/CaM-dependent kinases: from activation to function. | journal = Annu. Rev. Pharmacol. Toxicol. | volume = 41 | pages = 471–505 | year = 2001 | pmid = 11264466 | doi = 10.1146/annurev.pharmtox.41.1.471 }}
* {{cite journal | vauthors = Yamamoto H | title = [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions] | journal = Tanpakushitsu Kakusan Koso | volume = 47 | issue = 3 | pages = 241–7 | year = 2002 | pmid = 11889801 }}
* {{cite journal | vauthors = Countaway JL, Nairn AC, Davis RJ | title = Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase. | journal = J. Biol. Chem. | volume = 267 | issue = 2 | pages = 1129–40 | year = 1992 | doi = 10.1016/S0021-9258(18)48406-2 | pmid = 1309762 | doi-access = free }}
* {{cite journal | vauthors = Ikebe M, Reardon S | title = Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent multifunctional protein kinase. | journal = J. Biol. Chem. | volume = 265 | issue = 16 | pages = 8975–8 | year = 1990 | doi = 10.1016/S0021-9258(19)38796-4 | pmid = 2160950 | doi-access = free }}
* {{cite journal | vauthors = Czernik AJ, Pang DT, Greengard P | title = Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 84 | issue = 21 | pages = 7518–22 | year = 1987 | pmid = 3118371 | pmc = 299327 | doi = 10.1073/pnas.84.21.7518 | bibcode = 1987PNAS...84.7518C | doi-access = free }}
* {{cite journal | vauthors = Vulliet PR, Woodgett JR, Cohen P | title = Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase. | journal = J. Biol. Chem. | volume = 259 | issue = 22 | pages = 13680–3 | year = 1984 | doi = 10.1016/S0021-9258(18)89798-8 | pmid = 6150037 | doi-access = free }}
* {{cite journal | vauthors = Wen Z, Zhong Z, Darnell JE | title = Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. | journal = Cell | volume = 82 | issue = 2 | pages = 241–50 | year = 1995 | pmid = 7543024 | doi = 10.1016/0092-8674(95)90311-9 | s2cid = 6717533 | doi-access = free }}
* {{cite journal | vauthors = Kwiatkowski AP, McGill JM | title = Human biliary epithelial cell line Mz-ChA-1 expresses new isoforms of calmodulin-dependent protein kinase II. | journal = Gastroenterology | volume = 109 | issue = 4 | pages = 1316–23 | year = 1995 | pmid = 7557101 | doi = 10.1016/0016-5085(95)90594-4 | doi-access = free }}
* {{cite journal | vauthors = Shuai K, Stark GR, Kerr IM, Darnell JE | title = A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. | journal = Science | volume = 261 | issue = 5129 | pages = 1744–6 | year = 1993 | pmid = 7690989 | doi = 10.1126/science.7690989 | bibcode = 1993Sci...261.1744S }}
* {{cite journal | vauthors = Zhu J, Reynet C, Caldwell JS, Kahn CR | title = Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity. | journal = J. Biol. Chem. | volume = 270 | issue = 9 | pages = 4805–12 | year = 1995 | pmid = 7876254 | doi = 10.1074/jbc.270.9.4805 | doi-access = free }}
* {{cite journal | vauthors = Yakel JL, Vissavajjhala P, Derkach VA, Brickey DA, Soderling TR | title = Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 5 | pages = 1376–80 | year = 1995 | pmid = 7877986 | pmc = 42522 | doi = 10.1073/pnas.92.5.1376 | bibcode = 1995PNAS...92.1376Y | doi-access = free }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Suko J, Maurer-Fogy I, Plank B, Bertel O, Wyskovsky W, Hohenegger M, Hellmann G | title = Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase | journal = Biochim. Biophys. Acta | volume = 1175 | issue = 2 | pages = 193–206 | year = 1993 | pmid = 8380342 | doi = 10.1016/0167-4889(93)90023-I }}
* {{cite journal | vauthors = de Groot RP, den Hertog J, Vandenheede JR, Goris J, Sassone-Corsi P | title = Multiple and cooperative phosphorylation events regulate the CREM activator function | journal = EMBO J. | volume = 12 | issue = 10 | pages = 3903–11 | year = 1993 | pmid = 8404858 | pmc = 413673 | doi =  10.1002/j.1460-2075.1993.tb06068.x}}
* {{cite journal | vauthors = Nghiem P, Saati SM, Martens CL, Gardner P, Schulman H | title = Cloning and analysis of two new isoforms of multifunctional Ca2+/calmodulin-dependent protein kinase. Expression in multiple human tissues | journal = J. Biol. Chem. | volume = 268 | issue = 8 | pages = 5471–9 | year = 1993 | doi = 10.1016/S0021-9258(18)53345-7 | pmid = 8449910 | doi-access = free }}
* {{cite journal | vauthors = Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M | title = Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein | journal = J. Biol. Chem. | volume = 271 | issue = 30 | pages = 17957–60 | year = 1996 | pmid = 8663317 | doi = 10.1074/jbc.271.30.17957 | doi-access = free }}
* {{cite journal | vauthors = Wei J, Wayman G, Storm DR | title = Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo | journal = J. Biol. Chem. | volume = 271 | issue = 39 | pages = 24231–5 | year = 1996 | pmid = 8798667 | doi = 10.1074/jbc.271.39.24231 | doi-access = free }}
* {{cite journal | vauthors = Tombes RM, Krystal GW | title = Identification of novel human tumor cell-specific CaMK-II variants | journal = Biochim. Biophys. Acta | volume = 1355 | issue = 3 | pages = 281–92 | year = 1997 | pmid = 9060999 | doi = 10.1016/S0167-4889(96)00141-3 | doi-access =  }}
* {{cite journal | vauthors = Moyers JS, Bilan PJ, Zhu J, Kahn CR | title = Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II | journal = J. Biol. Chem. | volume = 272 | issue = 18 | pages = 11832–9 | year = 1997 | pmid = 9115241 | doi = 10.1074/jbc.272.18.11832 | doi-access = free }}
{{refend}}
==External links==
* {{UCSC gene info|CAMK2G}}
* {{PDBe-KB2|Q13555|Calcium/calmodulin-dependent protein kinase type II subunit gamma}}
{{PDB Gallery|geneid=818}}
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
{{NLM content}}
[[Category:EC 2.7.11]]
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