View source for CAMK4

{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
'''Calcium/calmodulin-dependent protein kinase type IV''' is an [[enzyme]] that in humans is encoded by the ''CAMK4'' [[gene]].<ref name="pmid2536634">{{cite journal | vauthors = Sikela JM, Law ML, Kao FT, Hartz JA, Wei Q, Hahn WE | title = Chromosomal localization of the human gene for brain Ca<sup>2+</sup>/calmodulin-dependent protein kinase type IV | journal = Genomics | volume = 4 | issue = 1 | pages = 21–7 |date=Mar 1989 | pmid = 2536634 | doi =10.1016/0888-7543(89)90309-1 }}</ref>
The product of this gene belongs to the [[serine/threonine protein kinase]] cluster, and to the [[CAMK|Ca<sup>2+</sup>/calmodulin-dependent protein kinase]] (CAMK) group. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in [[lymphocytes]], [[neurons]], and [[gamete|male germ cells]].<ref name="entrez">{{cite web | title = Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=814}}</ref>
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal | vauthors=Bredt DS, Ferris CD, Snyder SH |title=Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 10976–81 |year= 1992 |doi=10.1016/S0021-9258(19)49862-1 |pmid= 1375933 |doi-access=free }}
*{{cite journal | vauthors=Jensen KF, Ohmstede CA, Fisher RS, Sahyoun N |title=Nuclear and axonal localization of Ca<sup>2+</sup>/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 7 |pages= 2850–3 |year= 1991 |pmid= 2011593 |doi=10.1073/pnas.88.7.2850 | pmc=51337 |bibcode=1991PNAS...88.2850J |doi-access=free }}
*{{cite journal | vauthors=Selbert MA, Anderson KA, Huang QH |title=Phosphorylation and activation of Ca<sup>2+</sup>-calmodulin-dependent protein kinase IV by Ca<sup>2+</sup>-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation |journal=J. Biol. Chem. |volume=270 |issue= 29 |pages= 17616–21 |year= 1995 |pmid= 7615569 |doi= 10.1074/jbc.270.29.17616|display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Kitani T, Okuno S, Fujisawa H |title=cDNA cloning and expression of human calmodulin-dependent protein kinase IV |journal=J. Biochem. |volume=115 |issue= 4 |pages= 637–40 |year= 1994 |pmid= 8089075 |doi= 10.1093/oxfordjournals.jbchem.a124387}}
*{{cite journal | vauthors=Mosialos G, Hanissian SH, Jawahar S |title=A Ca<sup>2+</sup>/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1 |journal=J. Virol. |volume=68 |issue= 3 |pages= 1697–705 |year= 1994 |pmid= 8107230 |doi= 10.1128/JVI.68.3.1697-1705.1994| pmc=236629 |display-authors=etal}}
*{{cite journal | vauthors=Bland MM, Monroe RS, Ohmstede CA |title=The cDNA sequence and characterization of the Ca<sup>2+</sup>/calmodulin-dependent protein kinase-Gr from human brain and thymus |journal=Gene |volume=142 |issue= 2 |pages= 191–7 |year= 1994 |pmid= 8194751 |doi=10.1016/0378-1119(94)90260-7 }}
*{{cite journal | vauthors=Tokumitsu H, Soderling TR |title=Requirements for calcium and calmodulin in the calmodulin kinase activation cascade |journal=J. Biol. Chem. |volume=271 |issue= 10 |pages= 5617–22 |year= 1996 |pmid= 8621423 |doi=10.1074/jbc.271.10.5617 |doi-access=free }}
*{{cite journal | vauthors=Chatila T, Anderson KA, Ho N, Means AR |title=A unique phosphorylation-dependent mechanism for the activation of Ca<sup>2+</sup>/calmodulin-dependent protein kinase type IV/GR |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21542–8 |year= 1996 |pmid= 8702940 |doi=10.1074/jbc.271.35.21542 |doi-access=free }}
*{{cite journal | vauthors=Melander Gradin H, Marklund U, Larsson N |title=Regulation of microtubule dynamics by Ca<sup>2+</sup>/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18 |journal=Mol. Cell. Biol. |volume=17 |issue= 6 |pages= 3459–67 |year= 1997 |pmid= 9154845 |doi= 10.1128/mcb.17.6.3459| pmc=232199 |display-authors=etal}}
*{{cite journal | vauthors=Matsushita M, Nairn AC |title=Characterization of the mechanism of regulation of Ca<sup>2+</sup>/ calmodulin-dependent protein kinase I by calmodulin and by Ca<sup>2+</sup>/calmodulin-dependent protein kinase kinase |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21473–81 |year= 1998 |pmid= 9705275 |doi=10.1074/jbc.273.34.21473 |doi-access=free }}
*{{cite journal | vauthors=Anderson KA, Means RL, Huang QH |title=Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca<sup>2+</sup>/calmodulin-dependent protein kinase kinase beta |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31880–9 |year= 1998 |pmid= 9822657 |doi=10.1074/jbc.273.48.31880 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Hayashi Y, Nishio M, Naito Y |title=Regulation of neuronal nitric-oxide synthase by calmodulin kinases |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20597–602 |year= 1999 |pmid= 10400690 |doi=10.1074/jbc.274.29.20597 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Blaeser F, Ho N, Prywes R, Chatila TA |title=Ca<sup>2+</sup>-dependent gene expression mediated by MEF2 transcription factors |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 197–209 |year= 2000 |pmid= 10617605 |doi=10.1074/jbc.275.1.197 |doi-access=free }}
*{{cite journal | vauthors=Moreno CS, Park S, Nelson K |title=WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5257–63 |year= 2000 |pmid= 10681496 |doi=10.1074/jbc.275.8.5257 |pmc=3505218|display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Komeima K, Hayashi Y, Naito Y, Watanabe Y |title=Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28139–43 |year= 2000 |pmid= 10874031 |doi= 10.1074/jbc.M003198200 |doi-access= free }}
*{{cite journal | vauthors=Wu JY, Ribar TJ, Cummings DE |title=Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4 |journal=Nat. Genet. |volume=25 |issue= 4 |pages= 448–52 |year= 2000 |pmid= 10932193 |doi= 10.1038/78153 |s2cid=10803791 |display-authors=etal}}
*{{cite journal | vauthors=Jang MK, Goo YH, Sohn YC |title=Ca<sup>2+</sup>/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20005–10 |year= 2001 |pmid= 11274168 |doi= 10.1074/jbc.M010211200 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Hsu LS, Chen GD, Lee LS |title=Human Ca<sup>2+</sup>/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31113–23 |year= 2001 |pmid= 11395482 |doi= 10.1074/jbc.M011720200 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Zhao X, Ito A, Kane CD |title=The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 35042–8 |year= 2001 |pmid= 11470791 |doi= 10.1074/jbc.M105086200 |display-authors=etal|doi-access=free }}
*{{cite journal|title=Loss of the Ca<sup>2+</sup>/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine|publisher=PNAS|author=Ainhoa Bilbaoa|author2=Jan Rodriguez Parkitnab|author3=David Engblomb|author4=Stéphanie Perreau-Lenza|author5=Carles Sanchis-Seguraa|author6=Miriam Schneidera|author7=Witold Konopkab|author8=Magdalena Westphalb|author9=Gerome Breenc|author10=Sylvane Desrivieresc|author11=Matthias Klugmannd|author12=Camila Guindalinie|author13=Homero Valladag|author14=Ronaldo Laranjeirae|author15=Fernando Rodriguez de Fonsecah|author16=Gunter Schumannc|author17=Günther Schützb|author18=Rainer Spanagela|name-list-style=amp|pmid=19001277|doi=10.1073/pnas.0803959105|year=2008|volume=105|issue=45|pages=17549–54|pmc=2582267|journal=Proceedings of the National Academy of Sciences of the United States of America|bibcode=2008PNAS..10517549B |doi-access=free}}
*{{cite journal | vauthors=Feliciano DM, Edelman AM |title=Repression of Ca<sup>2+</sup>/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells.|journal=J. Biol. Chem. |volume=284 |issue= 39 |pages= 26466–81 |year= 2009 |pmid= 19633294 | doi=10.1074/jbc.M109.027680 | pmc=2785335|doi-access=free}}
{{refend}}
==External links==
* {{UCSC gene info|CAMK4}}
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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[[Category:EC 2.7.11]]
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