View source for CDD-2807

{{Short description|Chemical compound}}
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{{drugbox
| drug_name = CDD-2807
| image = CDD-2807_structure.png
| legal_UK =
| legal_DE =
| C = 29 | H = 26 | N = 4 | O = 1
| IUPAC_name = (3-([1,1'-Biphenyl]-2-ylethynyl)-1H-indazol-5-yl)(2,6-diazaspiro[3.5]nonan-2-yl)methanone
| CAS_number =
| CAS_supplemental =
| ChemSpiderID      =
| PubChem =
| smiles            = O=C(N1CC2(C1)CNCCC2)c1cc2c([NH]nc2C#Cc2ccccc2c2ccccc2)cc1
| StdInChI          = 1S/C29H26N4O/c34-28(33-19-29(20-33)15-6-16-30-18-29)23-12-14-27-25(17-23)26(31-32-27)13-11-22-9-4-5-10-24(22)21-7-2-1-3-8-21/h1-5,7-10,12,14,17,30H,6,15-16,18-20H2,(H,31,32)
| StdInChIKey       = YXMAOKMVGOSRPS-UHFFFAOYSA-N
}}
'''CDD-2807''' is a chemical compound which acts as a potent and selective inhibitor of [[Serine/threonine-specific protein kinase|serine/threonine-protein kinase]] 33 ([[STK33]]), with a IC<sub>50</sub> of 9.2 nM. In animal studies it causes production of abnormal sperm with reduced motility, and it has been investigated as a potential [[male contraceptive]] drug.<ref>{{cite journal | vauthors = Holdaway J, Georg GI | title = An emerging target for male contraception | journal = Science | volume = 384 | issue = 6698 | pages = 849–850 | date = May 2024 | pmid = 38781397 | doi = 10.1126/science.adp6432 | bibcode = 2024Sci...384..849H }}</ref><ref>{{cite journal | vauthors = Ku AF, Sharma KL, Ta HM, Sutton CM, Bohren KM, Wang Y, Chamakuri S, Chen R, Hakenjos JM, Jimmidi R, Kent K, Li F, Li JY, Ma L, Madasu C, Palaniappan M, Palmer SS, Qin X, Robers MB, Sankaran B, Tan Z, Vasquez YM, Wang J, Wilkinson J, Yu Z, Ye Q, Young DW, Teng M, Kim C, Matzuk MM | title = Reversible male contraception by targeted inhibition of serine/threonine kinase 33 | journal = Science | volume = 384 | issue = 6698 | pages = 885–890 | date = May 2024 | pmid = 38781365 | doi = 10.1126/science.adl2688 | bibcode = 2024Sci...384..885K }}</ref>
== See also ==
* [[JQ1]]
* [[TDI-11861]]
* [[YCT529]]
== References ==
{{reflist}}
{{pharm-stub}}
[[Category:Indazoles]]
[[Category:Biphenyls]]
[[Category:Carboxamides]]
[[Category:Azetidines]]
[[Category:Piperidines]]
[[Category:Spiro compounds]]
[[Category:Ethynyl compounds]]
[[Category:Nitrogen heterocycles]]