View source for CDK13

{{Short description|Protein-coding gene in humans}}
{{cs1 config|name-list-style=vanc|display-authors=6}}
{{Infobox_gene}}
'''Cyclin dependent kinase 13''' is an [[enzyme]] that in humans is encoded by the ''CDK13'' [[gene]].<ref name="pmid1731328">{{cite journal | vauthors = Lapidot-Lifson Y, Patinkin D, Prody CA, Ehrlich G, Seidman S, Ben-Aziz R, Benseler F, Eckstein F, Zakut H, Soreq H | title = Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis | journal = Proc Natl Acad Sci U S A | volume = 89 | issue = 2 | pages = 579–83 |date=Feb 1992 | pmid = 1731328 | pmc = 48282 | doi =10.1073/pnas.89.2.579  | doi-access = free | bibcode = 1992PNAS...89..579L }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDC2L5 cell division cycle 2-like 5 (cholinesterase-related cell division controller)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8621}}</ref>
The protein encoded by this gene is a member of the [[cyclin]]-dependent serine/[[threonine]] protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. Some of the cell cycle control kinases are able to [[phosphorylate]] proteins that are important for cell differentiation and [[apoptosis]], thus provide connections between cell proliferation, differentiation, and apoptosis. Proteins of this family may also be involved in non-cell cycle-related functions, such as [[neurocytoskeleton]] dynamics. The exact function of this protein has not yet been determined. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced variants are described.<ref name="entrez"/>
== Clinical significance ==
Mutations in ''CDK13'' cause [[CDK13-related disorder]]. A 2017 study of children with rare [[developmental disorder]]s found 11 children in the United Kingdom who had a fault in their ''CDK13'' gene.<ref>{{Cite journal|last1=McRae|first1=Jeremy F.|last2=Clayton|first2=Stephen|last3=Fitzgerald|first3=Tomas W.|last4=Kaplanis|first4=Joanna|last5=Prigmore|first5=Elena|last6=Rajan|first6=Diana|last7=Sifrim|first7=Alejandro|last8=Aitken|first8=Stuart|last9=Akawi|first9=Nadia|title=Prevalence and architecture of de novo mutations in developmental disorders|journal=Nature|volume=542|issue=7642|pages=433–438|doi=10.1038/nature21062|year=2017|hdl=20.500.11820/a89badba-7288-4be1-b3c5-a9b9e61d920d|url=http://eprints.whiterose.ac.uk/141471/1/Prevalence%20and%20architecture%20of%20de%20novo%20mutations%20in%20developmental%20disorders.pdf|pmid=28135719|pmc=6016744|bibcode=2017Natur.542..433M }}</ref> This fault affected the children's communication and language skills as well as causing learning difficulties.<ref>{{Cite news|url=https://www.bbc.co.uk/news/health-38691622|title=Child gene study identifies new developmental disorders|last=Walsh|first=Fergus|date=2017-01-25|newspaper=BBC News|language=en-GB|access-date=2017-01-27}}</ref>
==References==
{{reflist}}
==External links==
* {{UCSC gene info|CDK13}}
* {{PDBe-KB2|Q14004|Cyclin-dependent kinase 13}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
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*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  | author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S  }}
*{{cite journal  |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097  | author1= <Please add first missing authors to populate metadata.>|doi-access= free }}
*{{cite journal  | author=Marqués F |title=A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE motifs |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 832–7 |year= 2001 |pmid= 11162436 |doi= 10.1006/bbrc.2000.4042  | author2=Moreau JL  | author3=Peaucellier G  | last4=Lozano  | first4=JC  | last5=Schatt  | first5=P  | last6=Picard  | first6=A  | last7=Callebaut  | first7=I  | last8=Perret  | first8=E  | last9=Genevière  | first9=AM }}
*{{cite journal  | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=8 |issue= 2 |pages= 85–95 |year= 2001 |pmid= 11347906 |doi=10.1093/dnares/8.2.85  | author2=Nakayama M  | author3=Nakajima D  | last4=Kikuno  | first4=R  | last5=Ohara  | first5=O  |doi-access=free}}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  | author2=Feingold EA  | author3=Grouse LH  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  | author=Hillier LW |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782  | author2=Fulton RS  | author3=Fulton LA  | last4=Graves  | first4=Tina A.  | last5=Pepin  | first5=Kymberlie H.  | last6=Wagner-Mcpherson  | first6=Caryn  | last7=Layman  | first7=Dan  | last8=Maas  | first8=Jason  | last9=Jaeger  | first9=Sara |bibcode=2003Natur.424..157H | doi-access=free  }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  | author2=Suzuki Y  | author3=Nishikawa T  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki | doi-access=free  }}
*{{cite journal  | author=Brill LM |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d  | author2=Salomon AR  | author3=Ficarro SB  | last4=Mukherji  | first4=Mridul  | last5=Stettler-Gill  | first5=Michelle  | last6=Peters  | first6=Eric C. }}
*{{cite journal  | author=Colland F |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148  | author2=Jacq X  | author3=Trouplin V  | last4=Mougin  | first4=C  | last5=Groizeleau  | first5=C  | last6=Hamburger  | first6=A  | last7=Meil  | first7=A  | last8=Wojcik  | first8=J  | last9=Legrain  | first9=P }}
*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446  | author2=Jedrychowski M  | author3=Schwartz D  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP |bibcode=2004PNAS..10112130B |doi-access=free }}
*{{cite journal  | author=Andersen JS |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207  | author2=Lam YW  | author3=Leung AK  | last4=Ong  | first4=Shao-En  | last5=Lyon  | first5=Carol E.  | last6=Lamond  | first6=Angus I.  | last7=Mann  | first7=Matthias |bibcode=2005Natur.433...77A |s2cid=4344740 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  | author2=Venkatesan K  | author3=Hao T  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
*{{cite journal  | author=Even Y |title=CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo |journal=J. Cell. Biochem. |volume=99 |issue= 3 |pages= 890–904 |year= 2007 |pmid= 16721827 |doi= 10.1002/jcb.20986  | author2=Durieux S  | author3=Escande ML  | last4=Lozano  | first4=Jean Claude  | last5=Peaucellier  | first5=Gérard  | last6=Weil  | first6=Dominique  | last7=Genevière  | first7=Anne-Marie |s2cid=21022091 }}
*{{cite journal  | author=Tsang HT |title=A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex |journal=Genomics |volume=88 |issue= 3 |pages= 333–46 |year= 2006 |pmid= 16730941 |doi= 10.1016/j.ygeno.2006.04.003  | author2=Connell JW  | author3=Brown SE  | last4=Thompson  | first4=Amanda  | last5=Reid  | first5=Evan  | last6=Sanderson  | first6=Christopher M. | doi-access=}}
*{{cite journal  | author=Beausoleil SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240  | author2=Villén J  | author3=Gerber SA  | last4=Rush  | first4=John  | last5=Gygi  | first5=Steven P |s2cid=14294292 }}
*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026  | author2=Blagoev B  | author3=Gnad F  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias | doi-access=free  }}
{{refend}}
{{Serine/threonine-specific protein kinases}}
{{Cell cycle proteins}}
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[[Category:EC 2.7.11]]