View source for CEACAM8

{{Short description|Mammalian protein found in Homo sapiens}}
{{Infobox_gene}}
'''Carcinoembryonic antigen-related cell adhesion molecule 8''' ('''CEACAM8''') also known as '''CD66b''' ('''C'''luster of '''D'''ifferentiation '''66b'''), is a member of the [[carcinoembryonic antigen]] (CEA) [[gene]] family. Its main function is [[cell adhesion]], [[cell migration]], and [[pathogen]] binding.<ref name="entrez">{{cite web | title = Entrez Gene: CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1088}}</ref>
==Use==
CEACAM8 is expressed exclusively on [[Granulocyte|granulocytes]] and used as granulocyte marker.
==See also==
* [[Cluster of differentiation]]
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Khan WN, Frängsmyr L, Teglund S |title=Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. |journal=Genomics |volume=14 |issue= 2 |pages= 384–90 |year= 1992 |pmid= 1427854 |doi=10.1016/S0888-7543(05)80230-7  |display-authors=etal}}
*{{cite journal  | vauthors=Oikawa S, Inuzuka C, Kuroki M |title=A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. |journal=J. Biol. Chem. |volume=266 |issue= 13 |pages= 7995–8001 |year= 1991 |doi=10.1016/S0021-9258(18)92930-3 |pmid= 2022629 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Berling B, Kolbinger F, Grunert F |title=Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. |journal=Cancer Res. |volume=50 |issue= 20 |pages= 6534–9 |year= 1990 |pmid= 2208113 |display-authors=etal}}
*{{cite journal  | vauthors=Arakawa F, Kuroki M, Misumi Y |title=Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family. |journal=Biochem. Biophys. Res. Commun. |volume=166 |issue= 3 |pages= 1063–71 |year= 1990 |pmid= 2306228 |doi=10.1016/0006-291X(90)90975-S  |display-authors=etal}}
*{{cite journal  | vauthors=Eades-Perner AM, Thompson J, van der Putten H, Zimmermann W |title=Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. |journal=Blood |volume=91 |issue= 2 |pages= 663–72 |year= 1998 |pmid= 9427723 |doi=  10.1182/blood.V91.2.663|doi-access=free }}
*{{cite journal  | vauthors=Torsteinsdóttir I, Arvidson NG, Hällgren R, Håkansson L |title=Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids. |journal=Scand. J. Immunol. |volume=50 |issue= 4 |pages= 433–9 |year= 1999 |pmid= 10520185 |doi=10.1046/j.1365-3083.1999.00602.x  |s2cid=5692060 }}
*{{cite journal  | vauthors=Oikawa S, Sugiyama M, Kuroki M |title=Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 3 |pages= 564–8 |year= 2001 |pmid= 11095950 |doi= 10.1006/bbrc.2000.3858 |display-authors=etal}}
*{{cite journal  | vauthors=Singer BB, Scheffrahn I, Heymann R |title=Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. |journal=J. Immunol. |volume=168 |issue= 10 |pages= 5139–46 |year= 2002 |pmid= 11994468 |doi=  10.4049/jimmunol.168.10.5139|display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Zhao L, Xu S, Peterson C |title=Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes. |journal=J. Immunol. Methods |volume=270 |issue= 1 |pages= 27–35 |year= 2002 |pmid= 12379336 |doi=  10.1016/s0022-1759(02)00215-6|display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Grimwood J, Gordon LA, Olsen A |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |display-authors=etal|doi-access=free |url=https://digital.library.unt.edu/ark:/67531/metadc1408307/m2/1/high_res_d/15014060.pdf }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Ramachandran P, Boontheung P, Xie Y |title=Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. |journal=J. Proteome Res. |volume=5 |issue= 6 |pages= 1493–503 |year= 2006 |pmid= 16740002 |doi= 10.1021/pr050492k |display-authors=etal}}
{{refend}}
==External links==
* {{MeshName|CEACAM8+protein,+human}}
* {{UCSC gene info|CEACAM8}}
* [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P31997 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8)
{{NLM content}}
{{PDB Gallery|geneid=1088}}
{{Clusters of differentiation}}
[[Category:Clusters of differentiation]]
{{membrane-protein-stub}}