View source for CHRNB4

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Neuronal acetylcholine receptor subunit beta-4''' is a [[protein]] that in humans is encoded by the ''CHRNB4'' [[gene]].<ref name="pmid2004777">{{cite journal | vauthors = Eng CM, Kozak CA, Beaudet AL, Zoghbi HY|author-link4=Huda Zoghbi | title = Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse | journal = Genomics | volume = 9 | issue = 2 | pages = 278–282 |date=Apr 1991 | pmid = 2004777 | doi =10.1016/0888-7543(91)90253-B  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHRNB4 cholinergic receptor, nicotinic, beta 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1143}}</ref>
== Interactive pathway map ==
{{NicotineChromaffinActivity_WP1603|highlight=CHRNB4}}
==See also==
* [[Nicotinic acetylcholine receptor]]
==References==
{{reflist}}
==Further reading==
{{refbegin |30em}}
*{{cite journal  | vauthors=Green WN, Millar NS |title=Ion-channel assembly |journal=Trends Neurosci. |volume=18 |issue= 6 |pages= 280–287 |year= 1995 |pmid= 7571003 |doi=10.1016/0166-2236(95)93915-K  }}
*{{cite journal  | vauthors=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |pages= 1–46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1  | series=Reviews of Physiology, Biochemistry and Pharmacology  | isbn=978-3-540-01365-5 }}
*{{cite journal  | author=Tarroni P |title=Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines |journal=FEBS Lett. |volume=312 |issue= 1 |pages= 66–70 |year= 1992 |pmid= 1330682 |doi=10.1016/0014-5793(92)81411-E  |name-list-style=vanc| author2=Rubboli F  | author3=Chini B  | display-authors=3  | last4=Zwart  | first4=R  | last5=Oortgiesen  | first5=M  | last6=Sher  | first6=E  | last7=Clementi  | first7=F  | doi-access=free  |bibcode=1992FEBSL.312...66T }}
*{{cite journal  | vauthors=Anand R, Lindstrom J |title=Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans |journal=Genomics |volume=13 |issue= 4 |pages= 962–967 |year= 1992 |pmid= 1505988 |doi=10.1016/0888-7543(92)90008-G  }}
*{{cite journal  | author=Raimondi E |title=Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits |journal=Genomics |volume=12 |issue= 4 |pages= 849–50 |year= 1992 |pmid= 1572664 |doi=  10.1016/0888-7543(92)90324-L|name-list-style=vanc| author2=Rubboli F  | author3=Moralli D  | display-authors=3  | last4=Chini  | first4=B  | last5=Fornasari  | first5=D  | last6=Tarroni  | first6=P  | last7=De Carli  | first7=L  | last8=Clementi  | first8=F  }}
*{{cite journal  | author=Boulter J |title=Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster |journal=J. Biol. Chem. |volume=265 |issue= 8 |pages= 4472–82 |year= 1990 |pmid= 1689727 |name-list-style=vanc| author2=O'Shea-Greenfield A  | author3=Duvoisin RM  | display-authors=3  | last4=Connolly  | first4=JG  | last5=Wada  | first5=E  | last6=Jensen  | first6=A  | last7=Gardner  | first7=PD  | last8=Ballivet  | first8=M  | last9=Deneris  | first9=ES  |doi=10.1016/S0021-9258(19)39588-2 | doi-access=free  }}
*{{cite journal  | vauthors=Papke RL, Heinemann SF |title=The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors |journal=J. Physiol. |volume=440 |pages= 95–112 |year= 1992 |pmid= 1725184 |doi=  10.1113/jphysiol.1991.sp018698| pmc=1180142  }}
*{{cite journal  | author=Elliott KJ |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217–228 |year= 1997 |pmid= 8906617 |doi=10.1007/BF02736842  |name-list-style=vanc| author2=Ellis SB  | author3=Berckhan KJ  | display-authors=3  | last4=Urrutia  | first4=Arturo  | last5=Chavez-Noriega  | first5=Laura E.  | last6=Johnson  | first6=Edwin C.  | last7=Veliçelebi  | first7=Gönül  | last8=Harpold  | first8=Michael M.  |s2cid=45737923 }}
*{{cite journal  | author=Chavez-Noriega LE |title=Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes |journal=J. Pharmacol. Exp. Ther. |volume=280 |issue= 1 |pages= 346–56 |year= 1997 |pmid= 8996215 |name-list-style=vanc| author2=Crona JH  | author3=Washburn MS  | display-authors=3  | last4=Urrutia  | first4=A  | last5=Elliott  | first5=KJ  | last6=Johnson  | first6=EC  }}
*{{cite journal  | vauthors=Groot Kormelink PJ, Luyten WH |title=Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32 |journal=FEBS Lett. |volume=400 |issue= 3 |pages= 309–314 |year= 1997 |pmid= 9009220 |doi=10.1016/S0014-5793(96)01383-X  |doi-access=free }}
*{{cite journal  | vauthors=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433–42 |year= 1997 |pmid= 9193799 }}
*{{cite journal  | vauthors=Gerzanich V, Kuryatov A, Anand R, Lindstrom J |title="Orphan" alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor |journal=Mol. Pharmacol. |volume=51 |issue= 2 |pages= 320–7 |year= 1997 |doi=10.1124/mol.51.2.320 |pmid= 9203638 }}
*{{cite journal  | vauthors=Gerzanich V, Wang F, Kuryatov A, Lindstrom J |title=alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors |journal=J. Pharmacol. Exp. Ther. |volume=286 |issue= 1 |pages= 311–20 |year= 1998 |pmid= 9655874 }}
*{{cite journal  | author=Hellström-Lindahl E |title=Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord |journal=Brain Res. Dev. Brain Res. |volume=108 |issue= 1–2 |pages= 147–160 |year= 1998 |pmid= 9693793 |doi=10.1016/S0165-3806(98)00046-7  |name-list-style=vanc| author2=Gorbounova O  | author3=Seiger A  | display-authors=3  | last4=Mousavi  | first4=M  | last5=Nordberg  | first5=A  }}
*{{cite journal  | author=Sato KZ |title=Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines |journal=Neurosci. Lett. |volume=266 |issue= 1 |pages= 17–20 |year= 1999 |pmid= 10336173 |doi=10.1016/S0304-3940(99)00259-1  |name-list-style=vanc| author2=Fujii T  | author3=Watanabe Y  | display-authors=3  | last4=Yamada  | first4=Shin  | last5=Ando  | first5=Tsuyoshi  | last6=Kazuko  | first6=Fujimoto  | last7=Kawashima  | first7=Koichiro  |s2cid=43548155 }}
*{{cite journal  | vauthors=Boorman JP, Groot-Kormelink PJ, Sivilotti LG |title=Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes |journal=J. Physiol. |volume=529 |issue=  3|pages= 565–77 |year= 2001 |pmid= 11118490 |doi=  10.1111/j.1469-7793.2000.00565.x| pmc=2270211  }}
*{{cite journal  | author=Lev-Lehman E |title=Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4 |journal=J. Hum. Genet. |volume=46 |issue= 7 |pages= 362–366 |year= 2001 |pmid= 11450844 |doi=10.1007/PL00010921  |name-list-style=vanc| author2=Bercovich D  | author3=Xu W  | display-authors=3  | last4=Stockton  | first4=D. W.  | last5=Beaudet  | first5=A. L.  |doi-access=free}}
*{{cite journal  | vauthors=Groot-Kormelink PJ, Boorman JP, Sivilotti LG |title=Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach |journal=Br. J. Pharmacol. |volume=134 |issue= 4 |pages= 789–796 |year= 2001 |pmid= 11606319 |doi= 10.1038/sj.bjp.0704313  | pmc=1573006 }}
{{refend}}
== External links ==
* {{MeshName|CHRNB4+protein,+human}}
* {{UCSC gene info|CHRNB4}}
{{NLM content}}
{{Ligand-gated ion channels}}
[[Category:Ion channels]]
[[Category:Nicotinic acetylcholine receptors]]
{{membrane-protein-stub}}