View source for CP-944629

{{Chembox
| ImageFile = CP-944629.svg
| PIN = 3-''tert''-Butyl-6-[4-(2,4,5-trifluorophenyl)-1,3-oxazol-5-yl][1,2,4]triazolo[4,3-''a'']pyridine
|Section1={{Chembox Identifiers
| CASNo = 668990-94-1
| CASNo_Ref = {{Cascite|changed|}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = KB2ZD36HED
| PubChem = 9999342
| ChemSpiderID = 8174923
| ChEMBL = 212968
| DTXSID = DTXSID1057876
| StdInChI=1S/C19H15F3N4O/c1-19(2,3)18-25-24-15-5-4-10(8-26(15)18)17-16(23-9-27-17)11-6-13(21)14(22)7-12(11)20/h4-9H,1-3H3
| StdInChIKey = VNZJNPIWZYMGAO-UHFFFAOYSA-N
| SMILES = CC(C)(C)C1=NN=C2N1C=C(C=C2)C3=C(N=CO3)C4=CC(=C(C=C4F)F)F
}}
|Section2={{Chembox Properties
| C=19|H=15|F=3|N=4|O=1
}}
}}
'''CP-944629''', also known as 5-(3-[[tert-butyl|''tert''-butyl]]-[1,2,4]triazolo[4,3-''a'']pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazole (IUPAC name),<ref name=":1">{{Cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/9999342|title=1,2,4-Triazolo[4,3-A]pyridine, 3-(1,1-dimethylethyl)-6-[4-(2,4,5-trifluorophenyl)-5-oxazolyl]-|last=PubChem|website=pubchem.ncbi.nlm.nih.gov|language=en|access-date=2019-10-01|publisher=[[U.S. National Library of Medicine]]}}</ref> is a [[small molecule]] that is predicted to block [[DNA transcription]] by inhibiting [[DNA topoisomerase]].<ref>{{Cite web |url=http://amp.pharm.mssm.edu/Harmonizome/gene_set/CP-944629-7497/CMAP+Signatures+of+Differentially+Expressed+Genes+for+Small+Molecules |title=Gene Set - CP-944629-7497 |website=amp.pharm.mssm.edu |publisher=[[Icahn School of Medicine at Mount Sinai]] |location=New York City, U.S. |access-date=2019-10-05}}</ref><ref name=":0">{{Cite journal|last1=Chung|first1=Feng-Hsiang|last2=Jin|first2=Zhen-Hua|last3=Hsu|first3=Tzu-Ting|last4=Hsu|first4=Chueh-Lin|last5=Liu|first5=Hsueh-Chuan|last6=Lee|first6=Hoong-Chien|date=2015-10-16|title=Gene-Set Local Hierarchical Clustering (GSLHC)—A Gene Set-Based Approach for Characterizing Bioactive Compounds in Terms of Biological Functional Groups|journal=PLOS ONE|volume=10|issue=10|pages=e0139889|doi=10.1371/journal.pone.0139889|issn=1932-6203|pmc=4652590|pmid=26473729|bibcode=2015PLoSO..1039889C|doi-access=free}}</ref>
CP-944629 is thought to have [[Antitumor|anti-tumor]] activities.<ref name=":0" /> CP-944629 is assumed to be a [[MAPK14]] (mitogen-activated protein kinase 14 (human)) inhibitor<ref name=":1" /> and a p38alpha inhibitor.<ref>{{Cite web|url=https://www.medkoo.com/products/14674|title=CP-944629 {{!}} CAS#668990-94-1 {{!}} p38α Inhibitor {{!}} MedKoo|website=www.medkoo.com|access-date=2019-10-01}}</ref>
== References ==
{{reflist}}
[[Category:Topoisomerase inhibitors]]
[[Category:Triazolopyridines]]
[[Category:Oxazoles]]
[[Category:Fluoroarenes]]
[[Category:Tert-butyl compounds]]