View source for CPSF6

{{cs1 config|name-list-style=vanc}}
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
'''Cleavage and polyadenylation specificity factor subunit 6''' is a [[protein]] that in humans is encoded by the ''CPSF6'' [[gene]].<ref name="pmid9659921">{{cite journal | vauthors = Rüegsegger U, Blank D, Keller W | title = Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits | journal = Molecular Cell | volume = 1 | issue = 2 | pages = 243–53 | date = Jan 1998 | pmid = 9659921 | doi = 10.1016/S1097-2765(00)80025-8 | doi-access = free }}</ref><ref name="pmid17267687">{{cite journal | vauthors = Cardinale S, Cisterna B, Bonetti P, Aringhieri C, Biggiogera M, Barabino SM | title = Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit | journal = Molecular Biology of the Cell | volume = 18 | issue = 4 | pages = 1282–92 | date = Apr 2007 | pmid = 17267687 | pmc = 1838998 | doi = 10.1091/mbc.E06-09-0846 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CPSF6 cleavage and polyadenylation specific factor 6, 68kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11052}}</ref>
== Function ==
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.<ref name="entrez"/>
== Interactions ==
CPSF6 has been shown to [[Protein-protein interaction|interact]] with [[WWP1]]<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | display-authors = 6| title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R| s2cid = 4427026}}</ref> and [[PLSCR1]].<ref name=pmid16189514/>
CPSF6 plays an important role in the nuclear import and integration of [[HIV|HIV-1]] capsids.<ref>{{cite journal |last1=Müller |first1=Thorsten G. |last2=Zila |first2=Vojtech |last3=Müller |first3=Barbara |last4=Kräusslich |first4=Hans-Georg |title=Nuclear Capsid Uncoating and Reverse Transcription of HIV-1 |journal=Annual Review of Virology |date=29 September 2022 |volume=9 |issue=1 |pages=261–284 |doi=10.1146/annurev-virology-020922-110929|doi-access=free |pmid=35704745 }}</ref>
== References ==
{{reflist}}
==External links==
* {{UCSC gene info|CPSF6}}
== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Rüegsegger U, Beyer K, Keller W | title = Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors | journal = The Journal of Biological Chemistry | volume = 271 | issue = 11 | pages = 6107–13 | date = Mar 1996 | pmid = 8626397 | doi = 10.1074/jbc.271.11.6107 | doi-access = free }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W | title = Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors | journal = The EMBO Journal | volume = 19 | issue = 21 | pages = 5895–904 | date = Nov 2000 | pmid = 11060040 | pmc = 305781 | doi = 10.1093/emboj/19.21.5895 }}
* {{cite journal | vauthors = Awasthi S, Alwine JC | title = Association of polyadenylation cleavage factor I with U1 snRNP | journal = RNA | volume = 9 | issue = 11 | pages = 1400–9 | date = Nov 2003 | pmid = 14561889 | pmc = 1287061 | doi = 10.1261/rna.5104603 }}
* {{cite journal | vauthors = Brown KM, Gilmartin GM | title = A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im | journal = Molecular Cell | volume = 12 | issue = 6 | pages = 1467–76 | date = Dec 2003 | pmid = 14690600 | doi = 10.1016/S1097-2765(03)00453-2 | doi-access = free }}
* {{cite journal | vauthors = Dettwiler S, Aringhieri C, Cardinale S, Keller W, Barabino SM | title = Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization | journal = The Journal of Biological Chemistry | volume = 279 | issue = 34 | pages = 35788–97 | date = Aug 2004 | pmid = 15169763 | doi = 10.1074/jbc.M403927200 | s2cid = 39752996 | url = https://boa.unimib.it/bitstream/10281/4454/3/Dettwiler_et_al_Rev.pdf | doi-access = free }}
* {{cite journal | vauthors = Venkataraman K, Brown KM, Gilmartin GM | title = Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition | journal = Genes & Development | volume = 19 | issue = 11 | pages = 1315–27 | date = Jun 2005 | pmid = 15937220 | pmc = 1142555 | doi = 10.1101/gad.1298605 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
* {{cite journal | vauthors = Millevoi S, Loulergue C, Dettwiler S, Karaa SZ, Keller W, Antoniou M, Vagner S | title = An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries | journal = The EMBO Journal | volume = 25 | issue = 20 | pages = 4854–64 | date = Oct 2006 | pmid = 17024186 | pmc = 1618107 | doi = 10.1038/sj.emboj.7601331 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
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