View source for Centromere protein B

{{Short description|Protein-coding gene in the species Homo sapiens}}
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'''Centromere protein B''' also known as '''major centromere autoantigen B''' is an [[autoantigen]] protein of the [[cell nucleus]]. In humans, centromere protein B is encoded by the CENPB [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: centromere protein B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1059}}</ref><ref name="pmid8406460">{{cite journal | vauthors = Sugimoto K, Yata H, Himeno M | title = Mapping of the human CENP-B gene to chromosome 20 and the CENP-C gene to chromosome 12 by a rapid cycle DNA amplification procedure | journal = Genomics | volume = 17 | issue = 1 | pages = 240–242 | date = July 1993 | pmid = 8406460 | doi = 10.1006/geno.1993.1312 }}</ref><ref name="pmid11884609">{{cite journal | vauthors = Ando S, Yang H, Nozaki N, Okazaki T, Yoda K | title = CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells | journal = Molecular and Cellular Biology | volume = 22 | issue = 7 | pages = 2229–2241 | date = April 2002 | pmid = 11884609 | pmc = 133672 | doi = 10.1128/MCB.22.7.2229-2241.2002 }}</ref>
== Function ==
Centromere protein B is a highly conserved protein that facilitates [[centromere]] formation. It is a [[DNA]]-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
== Clinical significance ==
Centromere protein B is a potential [[biomarker]] of small-cell [[lung cancer]].<ref name="pmid17980453">{{cite journal | vauthors = Briasoulis E, Kamposioras K, Tzovaras V, Pafitanis G, Kostoula A, Mavridis A, Pavlidis N | title = CENP-B specific anti-centromere autoantibodies heralding small-cell lung cancer. A case study and review of the literature | journal = Lung Cancer | volume = 60 | issue = 2 | pages = 302–306 | date = May 2008 | pmid = 17980453 | doi = 10.1016/j.lungcan.2007.09.014 }}</ref>
== See also ==
* [[Centromere]]
== References ==
{{reflist}}
== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Saxena A, Wong LH, Kalitsis P, Earle E, Shaffer LG, Choo KH | title = Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc | journal = Human Molecular Genetics | volume = 11 | issue = 19 | pages = 2319–2329 | date = September 2002 | pmid = 12217960 | doi = 10.1093/hmg/11.19.2319 | doi-access = free }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–5396 | date = April 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | doi-access = free | bibcode = 2006PNAS..103.5391N }}
* {{cite journal | vauthors = Orthaus S, Biskup C, Hoffmann B, Hoischen C, Ohndorf S, Benndorf K, Diekmann S | title = Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells | journal = ChemBioChem | volume = 9 | issue = 1 | pages = 77–92 | date = January 2008 | pmid = 18072184 | doi = 10.1002/cbic.200700358 | s2cid = 37467765 }}
* {{cite journal | vauthors = Tawaramoto MS, Park SY, Tanaka Y, Nureki O, Kurumizaka H, Yokoyama S | title = Crystal structure of the human centromere protein B (CENP-B) dimerization domain at 1.65-A resolution | journal = The Journal of Biological Chemistry | volume = 278 | issue = 51 | pages = 51454–51461 | date = December 2003 | pmid = 14522975 | doi = 10.1074/jbc.M310388200 | doi-access = free }}
* {{cite journal | vauthors = Tanaka Y, Tachiwana H, Yoda K, Masumoto H, Okazaki T, Kurumizaka H, Yokoyama S | title = Human centromere protein B induces translational positioning of nucleosomes on alpha-satellite sequences | journal = The Journal of Biological Chemistry | volume = 280 | issue = 50 | pages = 41609–41618 | date = December 2005 | pmid = 16183641 | doi = 10.1074/jbc.M509666200 | doi-access = free }}
* {{cite journal | title = Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls | journal = Nature | volume = 447 | issue = 7145 | pages = 661–678 | date = June 2007 | pmid = 17554300 | pmc = 2719288 | doi = 10.1038/nature05911 | bibcode = 2007Natur.447..661B | vauthors = Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, Burton PR, Davison D, Donnelly P, Easton D, Evans D, Leung H, Marchini JL, Morris AP, Spencer CC, Tobin MD, Cardon LR, Clayton DG, Attwood AP, Boorman JP, Cant B, Everson U, Hussey JM }}
* {{cite journal | vauthors = Tanaka Y, Kurumizaka H, Yokoyama S | title = CpG methylation of the CENP-B box reduces human CENP-B binding | journal = The FEBS Journal | volume = 272 | issue = 1 | pages = 282–289 | date = January 2005 | pmid = 15634350 | doi = 10.1111/j.1432-1033.2004.04406.x | s2cid = 45738717 | doi-access = free }}
* {{cite journal | vauthors = Sowa ME, Bennett EJ, Gygi SP, Harper JW | title = Defining the human deubiquitinating enzyme interaction landscape | journal = Cell | volume = 138 | issue = 2 | pages = 389–403 | date = July 2009 | pmid = 19615732 | pmc = 2716422 | doi = 10.1016/j.cell.2009.04.042 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–814 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 | s2cid = 13709685 | doi-access = free }}
* {{cite journal | vauthors = Lomonte P, Morency E | title = Centromeric protein CENP-B proteasomal degradation induced by the viral protein ICP0 | journal = FEBS Letters | volume = 581 | issue = 4 | pages = 658–662 | date = February 2007 | pmid = 17258208 | doi = 10.1016/j.febslet.2007.01.027 | bibcode = 2007FEBSL.581..658L | s2cid = 27748450 }}
* {{cite journal | vauthors = Suzuki N, Nakano M, Nozaki N, Egashira S, Okazaki T, Masumoto H | title = CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5934–5946 | date = February 2004 | pmid = 14612452 | doi = 10.1074/jbc.M306477200 | doi-access = free }}
* {{cite journal | vauthors = Hellwig D, Münch S, Orthaus S, Hoischen C, Hemmerich P, Diekmann S | title = Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B | journal = Journal of Biophotonics | volume = 1 | issue = 3 | pages = 245–254 | date = August 2008 | pmid = 19412974 | doi = 10.1002/jbio.200810014 | s2cid = 22855465 }}
* {{cite journal | vauthors = Robitaille G, Hénault J, Christin MS, Senécal JL, Raymond Y | title = The nuclear autoantigen CENP-B displays cytokine-like activities toward vascular smooth muscle cells | journal = Arthritis and Rheumatism | volume = 56 | issue = 11 | pages = 3814–3826 | date = November 2007 | pmid = 17968937 | doi = 10.1002/art.22972 | doi-access = free }}
* {{cite journal | vauthors = Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K | title = Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase | journal = Genes to Cells | volume = 9 | issue = 2 | pages = 105–120 | date = February 2004 | pmid = 15009096 | doi = 10.1111/j.1365-2443.2004.00705.x | s2cid = 21813024 | doi-access = free }}
* {{cite journal | vauthors = Perdoni F, Bottone MG, Soldani C, Veneroni P, Alpini C, Pellicciari C, Scovassi AI | title = Distribution of centromeric proteins and PARP-1 during mitosis and apoptosis | journal = Annals of the New York Academy of Sciences | volume = 1171 | issue = 1 | pages = 32–37 | date = August 2009 | pmid = 19723035 | doi = 10.1111/j.1749-6632.2009.04729.x | last5 = Alpini | bibcode = 2009NYASA1171...32P | s2cid = 42584743 | first5 = Claudia | last7 = Scovassi | last6 = Pellicciari | first6 = Carlo | first7 = Anna Ivana }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = January 2005 | pmid = 15635413 | doi = 10.1038/nature03207 | s2cid = 4344740 | bibcode = 2005Natur.433...77A }}
* {{cite journal | vauthors = Robitaille G, Christin MS, Clément I, Senécal JL, Raymond Y | title = Nuclear autoantigen CENP-B transactivation of the epidermal growth factor receptor via chemokine receptor 3 in vascular smooth muscle cells | journal = Arthritis and Rheumatism | volume = 60 | issue = 9 | pages = 2805–2816 | date = September 2009 | pmid = 19714638 | doi = 10.1002/art.24765 | doi-access = free }}
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== External links ==
* {{MeshName|Centromere+protein+B}}
{{PDB Gallery|geneid=1059}}
{{Chromosome genetics}}
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