View source for Cornelia Catharina de Lange

{{short description|Dutch pediatrician (1871–1950)}}
{{Infobox person
| name               = Cornelia Catharina de Lange
| image              = Delange.jpg
| caption            =
| othername          =
| birth_name         =
| birth_date         = 24 June 1871
| birth_place        = [[Alkmaar]], North Holland
| death_date         = 28 January 1950
| death_place        = Amsterdam, Holland
| burial_place       =
| nationality        = Dutch
| alma_mater         = University of Amsterdam
| occupation         = Pediatrician and neuropathologist
| years_active       =
| known_for          = [[Cornelia de Lange syndrome]]
| spouse             =
| award              =
| mother             =
| father             =
| awards             = [[Order of Orange-Nassau]]
}}
'''Cornelia Catharina de Lange''' (24 June 1871 – 28 January 1950) was a Dutch [[pediatrician]] and neuropathologist who along with [[Winfried Brachmann]] first described the genetic disorder named after her, the [[Cornelia de Lange syndrome]].
==Life==
Born in [[Alkmaar]] to Catharina Jacoba Luchtmans, her mother, and Adrianus Petrus de Lange, a prominent lawyer in the city, de Lange was pushed to pursue an education in chemistry by her father.<ref name=":1">{{Cite book |last1=Beighton |first1=Peter |url=https://books.google.com/books?id=-TGgBQAAQBAJ |title=The Man Behind the Syndrome |last2=Beighton |first2=Greta |date=2012-12-06 |publisher=Springer Science & Business Media |isbn=978-1-4471-1415-4 |language=en}}</ref><ref>{{Cite web |last=Bosch |first=Mineke |date=2019-09-17 |title=Digitaal Vrouwenlexicon van Nederland (Digital Women's Lexicon of the Netherlands) |url=http://resources.huygens.knaw.nl/vrouwenlexicon/lemmata/data/Lange |access-date=2022-03-17 |website= |language=Dutch}}</ref> She enrolled in the University of Zurich to study chemistry but changed her focus to medicine in 1892.<ref name=":1" /> She graduated from the [[University of Amsterdam]] in 1897, becoming the fifth woman physician to qualify in the Netherlands.<ref name="cdl">{{cite web | url =http://www.cdlsusa.org/about-cdls-foundation/our-history.htm|title=History of the CdLS Foundation|publisher=CdLS Foundation| access-date =18 June 2015}}</ref><ref name=":0">{{Cite web |last=Bosch |first=Mineke |date=2013-11-12 |title=Lange, Cornelia Catharina de (1871-1950) |url=http://resources.huygens.knaw.nl/bwn1880-2000/lemmata/bwn2/langecc |access-date=2022-03-17 |website=Biographical Dictionary of the Netherlands |language=Dutch}}</ref> However, because pediatrics did not exist as a specialty in the Netherlands, De Lange moved to Switzerland, where she worked in the children's hospital in [[Zürich]] under Oskar Wyss.<ref name="cdl"/> She then returned to Amsterdam and practiced at Emma Kinderziekenhuis (Emma Children's Hospital).<ref name="cdl"/><ref name=":0" />
De Lange worked in all aspects of pediatrics. During her 50 years of practice she collected multiple observations of pediatric disorders.<ref name="doi">{{Cite journal | last1 = De Knecht-van Eekelen | first1 = Annemarie | last2 = Hennekam | first2 = Raoul C. M.  | year = 1994 | title = Historical study: Cornelia C. de Lange (1871–1950)—a pioneer in clinical genetics | journal = American Journal of Medical Genetics | volume = 52 | issue = 3 | pages = 257–266 | doi = 10.1002/ajmg.1320520302 | pmid=7810555}}</ref> De Lange also became interested in [[congenital disorders]] and their pediatric relevance as theories on [[human genetics]] developed during the 1920s and 1930s.<ref name="doi" /> In 1933, De Lange described what she called "typus degenerativus Amstelodamensis" (Amsterdam degeneration type) in two children, which became known as Cornelia de Lange syndrome.<ref name="cdl" />
She was knighted in 1947 by the Dutch government as a member of the [[Order of Orange-Nassau]].<ref>{{Cite web |last=Mueller |first=Jennifer |date=December 2016 |title=Cornelia de Lange Syndrome |url=https://genetics.pediatrics.med.ufl.edu/wordpress/files/2019/03/RCPU-Newsletter-December-2016.pdf |website=RCPU Newsletter |publisher=R.C. Phillips Research and Education Unit}}</ref> She died in Amsterdam at the age of 78.<ref name=":0" />
==References==
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{{DEFAULTSORT:Lange, Cornelia Catharina de}}
[[Category:1871 births]]
[[Category:1950 deaths]]
[[Category:Dutch pediatricians]]
[[Category:People from Alkmaar]]
[[Category:University of Amsterdam alumni]]
[[Category:Academic staff of the University of Amsterdam]]
[[Category:19th-century Dutch women]]
[[Category:19th-century Dutch women physicians]]
[[Category:20th-century Dutch women physicians]]
[[Category:20th-century Dutch physicians]]
[[Category:19th-century Dutch physicians]]
[[Category:Neuropathologists]]