View source for D-iditol 2-dehydrogenase

{{infobox enzyme
| Name       = {{sm|d}}-iditol 2-dehydrogenase
| EC_number  = 1.1.1.15
| CAS_number = 9028-22-2
| GO_code    = 0047824
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In [[enzymology]], a '''{{sm|d}}-iditol 2-dehydrogenase''' ({{EC number|1.1.1.15}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
:{{sm|d}}-iditol + NAD<sup>+</sup> <math>\rightleftharpoons</math> {{sm|d}}-sorbose + NADH + H<sup>+</sup>
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[Iditol|{{sm|d}}-iditol]] and [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], whereas its 3 [[product (chemistry)|products]] are [[Sorbose|{{sm|d}}-sorbose]], [[nicotinamide adenine dinucleotide|NADH]], and [[hydrogen ion|H<sup>+</sup>]].
This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The [[List of enzymes|systematic name]] of this enzyme class is '''{{sm|d}}-iditol:NAD<sup>+</sup> 2-oxidoreductase'''. This enzyme is also called '''{{sm|d}}-sorbitol dehydrogenase'''. This enzyme participates in [[pentose and glucuronate interconversions]] and [[Fructose metabolism|fructose]] and [[mannose metabolism]].
== References ==
{{reflist|1}}
* {{cite journal | vauthors = Shaw DR | title = Polyol dehydrogenases.  3.  Galactitol dehydrogenase and D-iditol dehydrogenase | journal = The Biochemical Journal | volume = 64 | issue = 3 | pages = 394–405 | date = November 1956 | pmid = 13373783 | pmc = 1199749 }}
{{Alcohol oxidoreductases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
[[Category:EC 1.1.1]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]
{{1.1.1-enzyme-stub}}