View source for DAB2IP

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Disabled homolog 2-interacting protein''' is a [[protein]] that in humans is encoded by the ''DAB2IP'' [[gene]].<ref name="pmid11944990">{{cite journal | vauthors = Chen H, Pong RC, Wang Z, Hsieh JT | title = Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization | journal = Genomics | volume = 79 | issue = 4 | pages = 573–81 |date=April 2002 | pmid = 11944990 | doi = 10.1006/geno.2002.6739 }}</ref><ref name="pmid11812785">{{cite journal | vauthors = Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT | title = The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2 | journal = J Biol Chem | volume = 277 | issue = 15 | pages = 12622–31 |date=April 2002 | pmid = 11812785 | doi = 10.1074/jbc.M110568200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DAB2IP DAB2 interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=153090}}</ref>
DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM]<ref name="entrez" />
==Interactions==
DAB2IP has been shown to [[Protein-protein interaction|interact]] with [[DAB2]].<ref name=autogenerated1>{{cite journal |last=Wang |first=Zhi |author2=Tseng Ching-Ping |author3=Pong Rey-Chen |author4=Chen Hong |author5=McConnell John D |author6=Navone Nora |author7=Hsieh Jer-Tsong  |date=April 2002  |title=The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2 |journal=J. Biol. Chem. |volume=277 |issue=15 |pages=12622–31 | issn = 0021-9258| pmid = 11812785 |doi = 10.1074/jbc.M110568200 |doi-access=free }}</ref>
==References==
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==Further reading==
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*{{cite journal  | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99  |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Nagase T, Kikuno R, Hattori A |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 6 |pages= 347–55 |year= 2001 |pmid= 11214970 |doi=10.1093/dnares/7.6.347  |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Chen H, Toyooka S, Gazdar AF, Hsieh JT |title=Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3121–30 |year= 2003 |pmid= 12446720 |doi= 10.1074/jbc.M208230200 |doi-access= free }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  | vauthors=Zhang R, He X, Liu W |title=AIP1 mediates TNF-α–induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3 |journal=J. Clin. Invest. |volume=111 |issue= 12 |pages= 1933–43 |year= 2003 |pmid= 12813029 |doi=10.1172/JCI17790  | pmc=161425  |display-authors=etal}}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=von Bergh AR, Wijers PM, Groot AJ |title=Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia |journal=Genes Chromosomes Cancer |volume=39 |issue= 4 |pages= 324–34 |year= 2004 |pmid= 14978793 |doi= 10.1002/gcc.20004 |s2cid=25835516 |display-authors=etal}}
*{{cite journal  | vauthors=Dote H, Toyooka S, Tsukuda K |title=Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer |journal=Clin. Cancer Res. |volume=10 |issue= 6 |pages= 2082–9 |year= 2004 |pmid= 15041729 |doi=10.1158/1078-0432.CCR-03-0236  |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465  | pmc=2734081 |display-authors=etal|bibcode=2004Natur.429..369H }}
*{{cite journal  | vauthors=Zhang H, Zhang R, Luo Y |title=AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 44955–65 |year= 2004 |pmid= 15310755 |doi= 10.1074/jbc.M407617200 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Yano M, Toyooka S, Tsukuda K |title=Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers |journal=Int. J. Cancer |volume=113 |issue= 1 |pages= 59–66 |year= 2004 |pmid= 15386433 |doi= 10.1002/ijc.20531 |s2cid=24207780 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Chen H, Tu SW, Hsieh JT |title=Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 22437–44 |year= 2005 |pmid= 15817459 |doi= 10.1074/jbc.M501379200 |doi-access= free }}
*{{cite journal  | vauthors=Kunze E, Von Bonin F, Werner C |title=Transitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elements |journal=Int. J. Mol. Med. |volume=17 |issue= 1 |pages= 3–13 |year= 2006 |pmid= 16328005 |doi=  10.3892/ijmm.17.1.3|display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 |display-authors=etal}}
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