View source for Delta12-fatty-acid desaturase

<span class="plainlinks"></span>{{Infobox enzyme
| Name       = Delta12-fatty-acid desaturase
| EC_number  = 1.14.19.6
| CAS_number =
| GO_code    =
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'''Delta12-fatty-acid desaturase''' ({{EC number|1.14.19.6}}, ''Delta12 fatty acid desaturase'', ''Delta12(omega6)-desaturase'', ''oleoyl-CoA Delta12 desaturase'', ''Delta12 desaturase'', ''Delta12-desaturase'') is an [[enzyme]] with [[List of enzymes|systematic name]] ''acyl-CoA,hydrogen donor:oxygen Delta12-oxidoreductase''.<ref>{{cite journal | vauthors = Borgeson CE, de Renobales M, Blomquist GJ | title = Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate | journal = Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | volume = 1047 | issue = 2 | pages = 135–40 | date = November 1990 | pmid = 2248971 | doi = 10.1016/0005-2760(90)90039-z }}</ref><ref>{{cite journal | vauthors = Jurenka RA | title = Biosynthetic pathway for producing the sex pheromone component (Z,E)-9,12-tetradecadienyl acetate in moths involves a delta 12 desaturase | journal = Cellular and Molecular Life Sciences | volume = 53 | issue = 6 | pages = 501–5 | date = June 1997 | pmid = 9230926 | doi = 10.1007/s000180050062 | s2cid = 20152524 | pmc = 11147184 }}</ref><ref>{{cite journal | vauthors = Lomascolo A, Dubreucq E, Galzy P | title = Study of the delta 12-desaturase system of Lipomyces starkeyi | journal = Lipids | volume = 31 | issue = 3 | pages = 253–9 | date = March 1996 | pmid = 8900454 | doi = 10.1007/bf02529871 | s2cid = 27459395 }}</ref><ref>{{cite journal | vauthors = Tocher DR, Leaver MJ, Hodgson PA | title = Recent advances in the biochemistry and molecular biology of fatty acyl desaturases | journal = Progress in Lipid Research | volume = 37 | issue = 2–3 | pages = 73–117 | year = 1998 | pmid = 9829122 | doi = 10.1016/s0163-7827(98)00005-8 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
: [[acyl-CoA]] + reduced acceptor + O<sub>2</sub> <math>\rightleftharpoons</math> Delta12-acyl-CoA + acceptor + 2 H<sub>2</sub>O
In the yeast ''[[Lipomyces starkeyi]]'' and in the [[American cockroach]], this [[microsom]]al enzyme converts [[oleoyl-CoA]] into [[linoleoyl-CoA]].
== References ==
{{reflist}}
== External links ==
* {{MeshName|Delta12-fatty-acid+desaturase}}
{{Dioxygenases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
[[Category:EC 1.14.19]]
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