View source for GGA3

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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''ADP-ribosylation factor-binding protein GGA3''' is a [[protein]] that in humans is encoded by the ''GGA3'' [[gene]].<ref name="pmid10747089">{{cite journal | vauthors = Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS | title = GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex | journal = The Journal of Cell Biology | volume = 149 | issue = 1 | pages = 81–94 | date = April 2000 | pmid = 10747089 | pmc = 2175099 | doi = 10.1083/jcb.149.1.81 }}</ref><ref name="pmid10749927">{{cite journal | vauthors = Boman AL, Zhang C, Zhu X, Kahn RA | title = A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi | journal = Molecular Biology of the Cell | volume = 11 | issue = 4 | pages = 1241–55 | date = April 2000 | pmid = 10749927 | pmc = 14844 | doi = 10.1091/mbc.11.4.1241 }}</ref>
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23163| access-date = }}</ref>
== Interactions ==
GGA3 has been shown to [[Protein-protein interaction|interact]] with [[ARF1]]<ref name=pmid10747089 /><ref name=pmid11301005>{{cite journal | vauthors = Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS | title = The GGAs promote ARF-dependent recruitment of clathrin to the TGN | journal = Cell | volume = 105 | issue = 1 | pages = 93–102 | date = April 2001 | pmid = 11301005 | doi = 10.1016/S0092-8674(01)00299-9 | s2cid = 1158816 | doi-access = free }}</ref> and [[ARF3]].<ref name=pmid10749927 /><ref name=pmid12221117>{{cite journal | vauthors = Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O | title = ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization | journal = Molecular Biology of the Cell | volume = 13 | issue = 9 | pages = 3078–95 | date = September 2002 | pmid = 12221117 | pmc = 124144 | doi = 10.1091/mbc.E02-02-0078 }}</ref>
== References ==
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== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 4 | pages = 167–74, 199–210 | date = August 1995 | pmid = 8590280 | doi = 10.1093/dnares/2.4.167 | doi-access = free }}
* {{cite journal | vauthors = Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS | title = A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome | journal = The Journal of Cell Biology | volume = 149 | issue = 1 | pages = 67–80 | date = April 2000 | pmid = 10747088 | pmc = 2175106 | doi = 10.1083/jcb.149.1.67 }}
* {{cite journal | vauthors = Takatsu H, Yoshino K, Nakayama K | title = Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin | journal = Biochemical and Biophysical Research Communications | volume = 271 | issue = 3 | pages = 719–25 | date = May 2000 | pmid = 10814529 | doi = 10.1006/bbrc.2000.2700 }}
* {{cite journal | vauthors = Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS | title = The GGAs promote ARF-dependent recruitment of clathrin to the TGN | journal = Cell | volume = 105 | issue = 1 | pages = 93–102 | date = April 2001 | pmid = 11301005 | doi = 10.1016/S0092-8674(01)00299-9 | s2cid = 1158816 | doi-access = free }}
* {{cite journal | vauthors = Puertollano R, Aguilar RC, Gorshkova I, Crouch RJ, Bonifacino JS | title = Sorting of mannose 6-phosphate receptors mediated by the GGAs | journal = Science | volume = 292 | issue = 5522 | pages = 1712–6 | date = June 2001 | pmid = 11387475 | doi = 10.1126/science.1060750 | bibcode = 2001Sci...292.1712P | s2cid = 30836125 }}
* {{cite journal | vauthors = Misra S, Puertollano R, Kato Y, Bonifacino JS, Hurley JH | title = Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains | journal = Nature | volume = 415 | issue = 6874 | pages = 933–7 | date = February 2002 | pmid = 11859375 | doi = 10.1038/415933a | bibcode = 2002Natur.415..933M | s2cid = 4430757 }}
* {{cite journal | vauthors = Takatsu H, Yoshino K, Toda K, Nakayama K | title = GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors | journal = The Biochemical Journal | volume = 365 | issue = Pt 2 | pages = 369–78 | date = July 2002 | pmid = 11950392 | pmc = 1222692 | doi = 10.1042/BJ20020428 }}
* {{cite journal | vauthors = Kato Y, Misra S, Puertollano R, Hurley JH, Bonifacino JS | title = Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism | journal = Nature Structural Biology | volume = 9 | issue = 7 | pages = 532–6 | date = July 2002 | pmid = 12032548 | doi = 10.1038/nsb807 | s2cid = 23740463 }}
* {{cite journal | vauthors = Doray B, Bruns K, Ghosh P, Kornfeld SA | title = Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 12 | pages = 8072–7 | date = June 2002 | pmid = 12060753 | pmc = 123022 | doi = 10.1073/pnas.082235699 | bibcode = 2002PNAS...99.8072D | doi-access = free }}
* {{cite journal | vauthors = Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS | title = Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics | journal = The Journal of Cell Biology | volume = 158 | issue = 5 | pages = 855–62 | date = September 2002 | pmid = 12213833 | pmc = 2173151 | doi = 10.1083/jcb.200205078 }}
* {{cite journal | vauthors = Doray B, Ghosh P, Griffith J, Geuze HJ, Kornfeld S | title = Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network | journal = Science | volume = 297 | issue = 5587 | pages = 1700–3 | date = September 2002 | pmid = 12215646 | doi = 10.1126/science.1075327 | bibcode = 2002Sci...297.1700D | s2cid = 8810528 }}
* {{cite journal | vauthors = Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O | title = ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization | journal = Molecular Biology of the Cell | volume = 13 | issue = 9 | pages = 3078–95 | date = September 2002 | pmid = 12221117 | pmc = 124144 | doi = 10.1091/mbc.E02-02-0078 }}
* {{cite journal | vauthors = Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS | title = Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex | journal = The EMBO Journal | volume = 22 | issue = 1 | pages = 78–88 | date = January 2003 | pmid = 12505986 | pmc = 140067 | doi = 10.1093/emboj/cdg015 }}
* {{cite journal | vauthors = Wakasugi M, Waguri S, Kametaka S, Tomiyama Y, Kanamori S, Shiba Y, Nakayama K, Uchiyama Y | title = Predominant expression of the short form of GGA3 in human cell lines and tissues | journal = Biochemical and Biophysical Research Communications | volume = 306 | issue = 3 | pages = 687–92 | date = July 2003 | pmid = 12810073 | doi = 10.1016/S0006-291X(03)01032-5 }}
* {{cite journal | vauthors = He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J | title = Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins | journal = Biochemistry | volume = 42 | issue = 42 | pages = 12174–80 | date = October 2003 | pmid = 14567678 | doi = 10.1021/bi035199h }}
* {{cite journal | vauthors = Ghosh P, Griffith J, Geuze HJ, Kornfeld S | title = Mammalian GGAs act together to sort mannose 6-phosphate receptors | journal = The Journal of Cell Biology | volume = 163 | issue = 4 | pages = 755–66 | date = November 2003 | pmid = 14638859 | pmc = 2173681 | doi = 10.1083/jcb.200308038 }}
* {{cite journal | vauthors = Shiba Y, Katoh Y, Shiba T, Yoshino K, Takatsu H, Kobayashi H, Shin HW, Wakatsuki S, Nakayama K | title = GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination | journal = The Journal of Biological Chemistry | volume = 279 | issue = 8 | pages = 7105–11 | date = February 2004 | pmid = 14660606 | doi = 10.1074/jbc.M311702200 | doi-access = free }}
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{{PDB Gallery|geneid=23163}}
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