View source for GMEB2

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Glucocorticoid modulatory element-binding protein 2''' is a [[protein]] that in humans is encoded by the ''GMEB2'' [[gene]].<ref name="pmid10523663">{{cite journal |vauthors=Christensen J, Cotmore SF, Tattersall P | title = Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites | journal = Mol Cell Biol | volume = 19 | issue = 11 | pages = 7741–50 |date=Nov 1999 | pmid = 10523663 | pmc = 84824 | doi =  10.1128/MCB.19.11.7741}}</ref><ref name="pmid11743720">{{cite journal |vauthors=Burnett E, Christensen J, Tattersall P | title = A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters | journal = J Mol Biol | volume = 314 | issue = 5 | pages = 1029–39 |date=Dec 2001 | pmid = 11743720 | doi = 10.1006/jmbi.2000.5198 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26205}}</ref>
This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites.<ref name="entrez">{{cite web | title = Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26205}}</ref>
==References==
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==Further reading==
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*{{cite journal  |vauthors=Nagase T, Ishikawa K, Kikuno R |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=10.1093/dnares/6.5.337  |display-authors=etal|doi-access=free }}
*{{cite journal  |vauthors=Kaul S, Blackford JA, Chen J |title=Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins. |journal=Mol. Endocrinol. |volume=14 |issue= 7 |pages= 1010–27 |year= 2000 |pmid= 10894151 |doi=10.1210/me.14.7.1010  |display-authors=etal|doi-access=free }}
*{{cite journal  |vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D |display-authors=etal|doi-access=free }}
*{{cite journal  |vauthors=Kaul S, Blackford JA, Cho S, Simons SS |title=Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12541–9 |year= 2002 |pmid= 11812797 |doi= 10.1074/jbc.M112330200 |doi-access= free }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  |vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |display-authors=etal|doi-access=free }}
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