View source for Glutamate-1-semialdehyde 2,1-aminomutase

{{infobox enzyme
| Name       = glutamate-1-semialdehyde 2,1-aminomutase
| EC_number  = 5.4.3.8
| CAS_number = 68518-07-0
| GO_code    = 0042286
| image      = 2epj.jpg
| width      = 270
| caption    = 2epj, Aeropyrum pernix (Archaea)
}}
In [[enzymology]], a '''glutamate-1-semialdehyde 2,1-aminomutase''' ({{EnzExplorer|5.4.3.8}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
:L-glutamate 1-semialdehyde <math>\rightleftharpoons</math> 5-aminolevulinate
Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[glutamate-1-semialdehyde|L-glutamate-1-semialdehyde]], and one [[product (chemistry)|product]], [[aminolevulinic acid|5-aminolevulinate]].
This enzyme belongs to the family of [[isomerase]]s, specifically those intramolecular [[transferase]]s transferring amino groups.  The [[List of enzymes|systematic name]] of this enzyme class is '''(S)-4-amino-5-oxopentanoate 4,5-aminomutase'''. This enzyme is also called '''glutamate-1-semialdehyde aminotransferase'''.  This enzyme participates in [[porphyrin]] and [[chlorophyll]] biosynthesis.  It employs one [[cofactor (biochemistry)|cofactor]], [[pyridoxal phosphate]].
==Structural studies==
As of late 2007, 10 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2CFB}}, {{PDB link|2E7U}}, {{PDB link|2EPJ}}, {{PDB link|2GSA}}, {{PDB link|2HOY}}, {{PDB link|2HOZ}}, {{PDB link|2HP1}}, {{PDB link|2HP2}}, {{PDB link|3GSB}}, and {{PDB link|4GSA}}.
==References==
{{reflist|1}}
* {{cite journal | vauthors = Gough SP, Kannangara CG | year = 1978 | title = Biosynthesis of delta-aminolevulinate in greening barley leaves: glutamate 1-semialdehyde aminotransferase | journal = Carlsberg Res. Commun.  | volume = 43 | issue = 3 | pages = 185–194 | doi = 10.1007/BF02914241 | doi-access = free }}
{{Mutases}}
{{Enzymes}}
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[[Category:EC 5.4.3]]
[[Category:Pyridoxal phosphate enzymes]]
[[Category:Enzymes of known structure]]
{{isomerase-stub}}