View source for HLA-B78

{{Short description|Genetic HLA-B serotype}}
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| align="center" colspan="2" | <div style="font-size:medium; line-height:120%;">major histocompatibility complex (human), class I, B78</div>
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| bgcolor="#e7dcc3" | Alleles
| bgcolor="#eeeeee" | B*7801 <br> B*7802 <br>
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| colspan="2" bgcolor="#dddddd" | '''Structure''' (See [[HLA-B]])
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| bgcolor="#e7dcc3" | [[Human Genome Organisation|Symbol(s)]]
| bgcolor="#eeeeee" | [https://web.archive.org/web/20070821210135/http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=4932 HLA-B]
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| bgcolor="#e7dcc3" | [[European Bioinformatics Institute|EBI-HLA]]
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?B*7801 B*7801]
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| bgcolor="#e7dcc3" | [[European Bioinformatics Institute|EBI-HLA]]
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?B*7802 B*7802]
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| bgcolor="#e7dcc3" | [[Locus (genetics)|Locus]]
| bgcolor="#eeeeee" | [[Chromosome 6 (human)|chr.6]] ''[https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31]''
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'''HLA-B78''' (B78) is an [[Human leukocyte antigen|HLA]]-[[HLA-B|B]] [[serotype]]. The serotype identifies the more common HLA-B*78 gene products.<ref name="pmid15787720">{{cite journal  |pmc=2848993 |date=2010 |last1=Marsh |first1=S. G. |title=Nomenclature for factors of the HLA system, 2010 |journal=[[Tissue Antigens (journal)|Tissue Antigens]] |volume=75 |issue=4 |pages=291–455 |last2=Albert |first2=E. D. |last3=Bodmer |first3=W. F. |last4=Bontrop |first4=R. E. |last5=Dupont |first5=B. |last6=Erlich |first6=H. A. |last7=Fernández-Viña |first7=M. |last8=Geraghty |first8=D. E. |last9=Holdsworth |first9=R. |last10=Hurley |first10=C. K. |last11=Lau |first11=M. |last12=Lee |first12=K. W. |last13=Mach |first13=B. |last14=Maiers |first14=M. |last15=Mayr |first15=W. R. |last16=Müller |first16=C. R. |last17=Parham |first17=P. |last18=Petersdorf |first18=E. W. |last19=Sasazuki |first19=T. |last20=Strominger |first20=J. L. |last21=Svejgaard |first21=A. |last22=Terasaki |first22=P. I. |last23=Tiercy |first23=J. M. |last24=Trowsdale |first24=J. |pmid=20356336 |doi=10.1111/j.1399-0039.2010.01466.x }}</ref> B78 is more common in West and North Africa, but is also scattered at low frequencies in parts of Asia. (For terminology help see: [[HLA-A#Historical Guide to Understanding Nomenclature|HLA-serotype tutorial]])
==Serotype==
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|+ B78 serotype recognition of some HLA B*78 allele-group gene products<ref>[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]</ref>
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| style="width:60px" | B*78 || style="width:60px" | '''B78'''
| style="width:60px" | other  || style="width:60px" | Sample
|- style="background:#f0f0ff"
| allele || % || % || size (N)
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| style = "background:#e8e8f8" | 7801 || 41 || 48 || 210
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==Allele frequencies==
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|+ '''HLA B*7801 frequencies'''
|- style="background:#efe5ef"
|  ||   || freq
|- style="background:#eee5ef"
| ref. || align="left" |Population || style="width:50px" | (%)
|-
| <ref name = "pmid12753660">{{cite journal |author-last1=Middleton |author-first1=D. |author-last2=Menchaca |author-first2=L. |author-last3=Rood |author-first3=H. |author-last4=Komerofsky |author-first4=R. |title=New allele frequency database: <nowiki>http://www.allelefrequencies.net</nowiki> |journal=[[Tissue Antigens (journal)|Tissue Antigens]] |volume=61 |issue=5 |pages=403–407 |date=2003 |pmid=12753660 |doi=10.1034/j.1399-0039.2003.00062.x|doi-access=free }}</ref>  || align="left"| [[Fulani]] ([[Burkina Faso]])||8.2
|-
| <ref name = "pmid12753660"/> || align="left"|[[Bandiagara]] ([[Mali]]) ||6.9
|-
| <ref name = "pmid12753660"/> || align="left"|Niokholo [[Mandinka people|Mandinka]] ([[Senegal]]) ||5.3
|-
| <ref name = "pmid12753660"/> || align="left"|[[Mossi people|Mossi]] (Burkina Faso)||2.8
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| <ref name = "pmid12753660"/> || align="left"|[[Guinea Bissau]]||2.3
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| <ref name = "pmid12753660"/> || align="left"|Akan Adiopodoume ([[Ivory Coast]]) ||2.3
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| <ref name = "pmid12753660"/> || align="left"|Tunis ([[Tunisia]])||2.3
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| <ref name = "pmid12753660"/> || align="left"|[[Berber people|Berber]] ([[Morocco]])||1.4
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| <ref name = "pmid12753660"/> || align="left"|Rimaibe (Burkina Faso)||1.1
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| <ref name = "pmid12753660"/> || align="left"|[[New Delhi]] ([[India]])||0.8
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| <ref name = "pmid12753660"/> || align="left"|Lisu (Yunnan, China)||0.7
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| <ref name = "pmid12753660"/> || align="left"|Beti (Cameroon)||0.6
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| <ref name = "pmid12753660"/> || align="left"|Majorca & Minorca (Spain)||0.6
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| <ref name = "pmid12753660"/> || align="left"|Gypsy (E. Andalusia, Spain)||0.5
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| <ref name = "pmid12753660"/> || align="left"|Tunisia||0.5
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| <ref name = "pmid12753660"/> || align="left"|Romanian||0.3
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| <ref name = "pmid12753660"/> || align="left"|Northeast Thailand||0.2
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| <ref name = "pmid12753660"/> || align="left"|Tibet ([[China]])||0.6
|-
| colspan=3 align="right"| '
|-style="background:#ffffff;"
| colspan=3 | '''HLA B*7802 frequencies'''
|-
| <ref name = "pmid12753660"/> || align="left"|Svans (Georgia)||0.6
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| <ref name = "pmid12753660"/> || align="left"|Arab Druse (Israel)||0.5
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| <ref name = "pmid12753660"/> || align="left"|Delhi (India) ||0.5
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| <ref name = "pmid12753660"/> || align="left"|Southern Han (China) ||0.2
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| <ref name = "pmid12753660"/> || align="left"|Beijing (China) ||0.1
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==References==
{{reflist}}
{{HLA-B serotypes}}
{{DEFAULTSORT:Hla-B78}}
[[Category:HLA-B alleles|7]]