View source for Hol-Tox family

{{Short description|Class of transmembrane transport proteins}}
The putative '''holin-like toxin (Hol-Tox) family''' ([http://tcdb.org/search/result.php?tc=1.E.42 TC# 1.E.42]) consists of many small proteins, between 34 and 48 amino acyl residues (aas) with a single transmembrane segment (TMSs). Rajesh et al. ([http://tcdb.org/search/result.php?tc=1.E.42#ref9620 2011]) first identified the gene and designated it ''tmp1'', which coded for a 34 amino acyl peptide that acts as an antibacterial agent on [[gram-positive bacteria]].<ref name=":0">{{Cite journal|last1=Rajesh|first1=Thangamani|last2=Anthony|first2=Thangamani|last3=Saranya|first3=Subramani|last4=Pushpam|first4=Paul Lavanya|last5=Gunasekaran|first5=Paramasamy|date=2011-02-01|title=Functional characterization of a new holin-like antibacterial protein coding gene tmp1 from goat skin surface metagenome|journal=Applied Microbiology and Biotechnology|volume=89|issue=4|pages=1061–1073|doi=10.1007/s00253-010-2907-6|issn=1432-0614|pmid=20927512|s2cid=9315098}}</ref> This peptide exhibits a single [[transmembrane domain]] (TMD) that is believed to play a role in facilitating the antibacterial activity.<ref name=":0" /> A representative list of proteins belonging to the Hol-Tox family can be found in the [[Transporter Classification Database]].<ref>{{Cite web|url=http://tcdb.org/search/result.php?tc=1.E.42|title=1.E.42 The Putative Holin-like Toxin (Hol-Tox) Family|website=TCDB|access-date=2016-03-28}}</ref>
== See also ==
* [[Holin]]
* [[Lysin]]
== Further reading ==
* {{cite journal | last1 = Reddy | first1 = Bhaskara L. | last2 = Saier Jr | first2 = Milton H. | year = 2013 | title = Topological and phylogenetic analyses of bacterial holin families and superfamilies | url= | journal = Biochimica et Biophysica Acta (BBA) - Biomembranes | volume = 1828 | issue = 11| pages = 2654–2671 | doi = 10.1016/j.bbamem.2013.07.004 | pmid = 23856191 | pmc = 3788059 }}
* {{cite journal | last1 = Saier | first1 = Milton H. | last2 = Reddy | first2 = Bhaskara L. | year = 2015 | title = Holins in Bacteria, Eukaryotes, and Archaea: Multifunctional Xenologues with Potential Biotechnological and Biomedical Applications | journal = Journal of Bacteriology | volume = 197 | issue = 1| pages = 7–17 | doi = 10.1128/JB.02046-14 | pmid = 25157079 | pmc = 4288690 }}
* {{cite journal | last1 = Wang | first1 = I. N. | last2 = Smith | first2 = D. L. | last3 = Young | first3 = R. | year = 2000 | title = Holins: the protein clocks of bacteriophage infections | journal = Annual Review of Microbiology | volume = 54 | pages = 799–825 | doi = 10.1146/annurev.micro.54.1.799 | pmid = 11018145 }}
* {{cite journal | last1 = Young | first1 = R. | last2 = Bläsi | first2 = U. | year = 1995 | title = Holins: form and function in bacteriophage lysis | journal = FEMS Microbiology Reviews | volume = 17 | issue = 1–2| pages = 191–205 | doi = 10.1111/j.1574-6976.1995.tb00202.x | pmid = 7669346 }}
== References ==
{{Reflist}}
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[[Category:Protein families]]
[[Category:Membrane proteins]]
[[Category:Transmembrane proteins]]
[[Category:Transmembrane transporters]]
[[Category:Transport proteins]]
[[Category:Integral membrane proteins]]
[[Category:Holins]]