View source for Hyoscyamine (6S)-dioxygenase

{{infobox enzyme
| Name       = hyoscyamine (6S)-dioxygenase
| EC_number  = 1.14.11.11
| CAS_number = 103865-33-4
| GO_code    = 0047998
| image      =
| width      =
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In [[enzymology]], a '''hyoscyamine (6S)-dioxygenase''' ({{EC number|1.14.11.11}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
:L-hyoscyamine + 2-oxoglutarate + O<sub>2</sub> <math>\rightleftharpoons</math> (6S)-hydroxyhyoscyamine + succinate + CO<sub>2</sub>
The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[L-hyoscyamine]], [[2-oxoglutarate]], and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[(6S)-hydroxyhyoscyamine]], [[succinate]], and [[carbon dioxide|CO<sub>2</sub>]].
This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor.  The [[List of enzymes|systematic name]] of this enzyme class is '''L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)'''. Other names in common use include '''hyoscyamine 6beta-hydroxylase''', '''hyoscyamine 6beta-dioxygenase''', and '''hyoscyamine 6-hydroxylase'''.  This enzyme participates in [[alkaloid biosynthesis ii]].  It has 2 [[cofactor (biochemistry)|cofactors]]: [[iron]],  and [[Ascorbate]].
== References ==
{{reflist|1}}
* {{cite journal | vauthors = Hashimoto T, Yamada Y | title = Hyoscyamine 6beta-hydroxylase, a 2-oxoglutarate-dependent dioxygenase, in alkaloid-producing root cultures | journal = Plant Physiology | volume = 81 | issue = 2 | pages = 619–25 | date = June 1986 | pmid = 16664866 | pmc = 1075387 | doi = 10.1104/pp.81.2.619 }}
{{Dioxygenases}}
{{Enzymes}}
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[[Category:EC 1.14.11]]
[[Category:Iron enzymes]]
[[Category:Ascorbate enzymes]]
[[Category:Enzymes of unknown structure]]
{{1.14-enzyme-stub}}