View source for IRF9

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Interferon regulatory factor 9''' is a [[protein]] that in humans is encoded by the ''IRF9'' [[gene]], previously known as ISGF3G.<ref name="pmid1630447">{{cite journal |vauthors=Veals SA, Schindler C, Leonard D, Fu XY, Aebersold R, ((Darnell JE Jr)), Levy DE | title = Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins | journal = Mol Cell Biol | volume = 12 | issue = 8 | pages = 3315–24 |date=Aug 1992 | pmid = 1630447 | pmc = 364572 | doi =  10.1128/MCB.12.8.3315}}</ref><ref name="pmid10199920">{{cite journal |vauthors=McCusker D, Wilson M, Trowsdale J | title = Organization of the genes encoding the human proteasome activators PA28alpha and beta | journal = Immunogenetics | volume = 49 | issue = 5 | pages = 438–45 |date=Jun 1999 | pmid = 10199920 | doi =10.1007/s002510050517  | s2cid = 40575791 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10379}}</ref>
==Interactions==
IRF9 has been shown to [[Protein-protein interaction|interact]] with [[STAT2]]<ref name=pmid8943351>{{cite journal |last=Horvath |first=C M |author2=Stark G R |author3=Kerr I M |author4=Darnell J E  |date=Dec 1996 |title=Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex |journal=Mol. Cell. Biol. |volume=16 |issue=12 |pages=6957–64 |location = UNITED STATES| issn = 0270-7306| pmid = 8943351 | pmc = 231699 | doi=10.1128/mcb.16.12.6957}}</ref><ref name=pmid9242679>{{cite journal |last=Martinez-Moczygemba |first=M |author2=Gutch M J |author3=French D L |author4=Reich N C  |date=Aug 1997 |title=Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3 |journal=J. Biol. Chem. |volume=272 |issue=32 |pages=20070–6 |location = UNITED STATES| issn = 0021-9258| pmid = 9242679 | doi = 10.1074/jbc.272.32.20070 |doi-access=free }}</ref> and [[STAT1]].<ref name=pmid8943351/>
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  |vauthors=Cebulla CM, Miller DM, Sedmak DD |title=Viral inhibition of interferon signal transduction |journal=Intervirology |volume=42 |issue= 5–6 |pages= 325–30 |year= 2000 |pmid= 10702714 |doi=10.1159/000053968  |s2cid=22135982 }}
*{{cite journal  | author=Reich NC |title=Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation |journal=J. Interferon Cytokine Res. |volume=22 |issue= 1 |pages= 103–9 |year= 2002 |pmid= 11846981 |doi= 10.1089/107999002753452719 }}
*{{cite journal   |vauthors=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, etal |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
*{{cite journal   |vauthors=David M, Romero G, Zhang ZY, etal |title=In vitro activation of the transcription factor ISGF3 by interferon alpha involves a membrane-associated tyrosine phosphatase and tyrosine kinase |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6593–9 |year= 1993 |doi=10.1016/S0021-9258(18)53292-0 |pmid= 8454630 |doi-access=free }}
*{{cite journal  |vauthors=Horvath CM, Stark GR, Kerr IM, Darnell JE |title=Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 6957–64 |year= 1997 |pmid= 8943351 |doi=  10.1128/mcb.16.12.6957| pmc=231699  }}
*{{cite journal  |vauthors=Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC |title=Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3 |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 20070–6 |year= 1997 |pmid= 9242679 |doi=10.1074/jbc.272.32.20070  |doi-access=free }}
*{{cite journal  |vauthors=Reddy PH, Stockburger E, Gillevet P, Tagle DA |title=Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method |journal=Genomics |volume=46 |issue= 2 |pages= 174–82 |year= 1998 |pmid= 9417904 |doi= 10.1006/geno.1997.5044 |url=https://zenodo.org/record/1229747 }}
*{{cite journal  |vauthors=Lau JF, Parisien JP, Horvath CM |title=Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7278–83 |year= 2000 |pmid= 10860992 |doi=10.1073/pnas.97.13.7278  | pmc=16536  |bibcode=2000PNAS...97.7278L |doi-access=free }}
*{{cite journal  |vauthors=Nehyba J, Hrdlicková R, Burnside J, Bose HR |title=A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3942–57 |year= 2002 |pmid= 11997525 |doi=10.1128/MCB.22.11.3942-3957.2002  | pmc=133824  }}
*{{cite journal   |vauthors=Chawla-Sarkar M, Leaman DW, Jacobs BS, etal |title=Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (Stat1) |journal=J. Interferon Cytokine Res. |volume=22 |issue= 5 |pages= 603–13 |year= 2002 |pmid= 12060499 |doi= 10.1089/10799900252982089 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Lau JF, Nusinzon I, Burakov D, etal |title=Role of Metazoan Mediator Proteins in Interferon-Responsive Transcription |journal=Mol. Cell. Biol. |volume=23 |issue= 2 |pages= 620–8 |year= 2003 |pmid= 12509459 |doi=10.1128/MCB.23.2.620-628.2003  | pmc=151539  }}
*{{cite journal   |vauthors=Jikuya H, Takano J, Kikuno R, etal |title=Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones |journal=DNA Res. |volume=10 |issue= 1 |pages= 49–57 |year= 2003 |pmid= 12693554 |doi=10.1093/dnares/10.1.49  |doi-access=free }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal  |vauthors=Thompson HG, Harris JW, Lin L, Brody JP |title=Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells |journal=Exp. Cell Res. |volume=295 |issue= 2 |pages= 448–59 |year= 2004 |pmid= 15093743 |doi= 10.1016/j.yexcr.2004.01.019 }}
*{{cite journal  |vauthors=Sakamoto S, Potla R, Larner AC |title=Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes |journal=J. Biol. Chem. |volume=279 |issue= 39 |pages= 40362–7 |year= 2004 |pmid= 15194680 |doi= 10.1074/jbc.M406400200 |doi-access= free }}
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== External links ==
* {{MeshName|ISGF3G+protein,+human}}
* {{UCSC genome browser|IRF9}}
* {{UCSC gene details|IRF9}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{protein-stub}}