View source for KatG

{{Molecular-cell-biology-stub}}
'''KatG''' is an [[enzyme]] that functions as both [[catalase]] and [[peroxidase]]. In ''[[Mycobacterium|Mycobacterium tuberculosis]],'' mutations in KatG are commonly associated with resistance to the antibiotic drug [[isoniazid]], which targets the [[mycolic acid]]s within ''M. tuberculosis'', and more general [[Multiple drug resistance|multi-drug resistance]].<ref>{{Cite journal|last=Johnsson|first=Kai|title=Overexpression, Purification, and Characterization of the Catalase-peroxidase KatG from Mycobacterium tuberculosis|url=https://www.jbc.org/article/S0021-9258(19)67381-3/fulltext|journal=Journal of Biological Chemistry|year=1997|volume=272|issue=5|pages=2834–2840|doi=10.1074/jbc.272.5.2834|pmid=9006925|s2cid=23882303|via=Elsevier|doi-access=free}}</ref><ref>{{Cite journal |last1=Tracevska |first1=T. |last2=Jansone |first2=I. |last3=Broka |first3=L. |last4=Marga |first4=O. |last5=Baumanis |first5=V. |date=2002-10-01 |title=Mutations in the rpoB and katG Genes Leading to Drug Resistance in Mycobacterium tuberculosis in Latvia |journal=Journal of Clinical Microbiology |language=en |volume=40 |issue=10 |pages=3789–3792 |doi=10.1128/JCM.40.10.3789-3792.2002 |issn=0095-1137 |pmc=130873 |pmid=12354882}}</ref> Due to both its catalase and peroxidase activity, this enzyme protects ''M. tuberculosis'' against [[reactive oxygen species]]. ''M. tuberculosis''<nowiki/>' survival within macrophages depends on the KatG enzyme.<ref>{{Cite journal|last=Heym|first=B|date=July 1993|title=Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis|journal=Journal of Bacteriology|volume=175|issue=13|pages=4255–4259|doi=10.1128/jb.175.13.4255-4259.1993|pmid=8320241|pmc=204858}}</ref><ref>{{Cite journal|last=Cockerill|first=FR|date=1995|title=Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance|url=https://pubmed.ncbi.nlm.nih.gov/7798673/|journal=The Journal of Infectious Diseases|volume=171|issue=1|pages=240–245|doi=10.1093/infdis/171.1.240|pmid=7798673|via=Pubmed}}</ref>
==Reference==
{{reflist}}{{DEFAULTSORT:KatG}}
[[Category:Bacterial enzymes]]
[[Category:Drug resistance]]
[[Category:Molecular biology stubs]]
[[Category:Proteins]]