View source for Knife-edge scanning microscope

The '''Knife-Edge Scanning Microscope''' (KESM) was invented and [[patent]]ed in the late 1990s by [[Bruce McCormick]] at [[Texas A&M University]].<ref>Kathy Flores (2007). "Dr. Bruce H. McCormick" Texas A&M University. Retrieved 9 July 2008.</ref> The microscope is intended to produce [[high-resolution]] data sets in order to reconstruct 3D [[Cell (biology)#subcellular components|cellular structures]].
The machine is capable of handling tissue volumes of 1 to 100mm<sup>3</sup>, recording large volumes of tissue in a small amount of time (~7mm<sup>2</sup>s<sup>−1</sup>).<ref>B. H. McCormick, Development of the Brain Tissue Scanner, Technical Report, Brain Networks Laboratory, Department of Computer Science, Texas A&M University, College Station, Texas, 2002. [PDF]</ref> The resolution and scanning speed of KESM is a novel method for imaging tissue at resolutions sufficient to reconstruct maps of cellular distribution and [[Morphology (biology)|morphology]]. The technique preserves the alignment of serial sections accurately enough to reconstruct [[neuron]]al processes and microvasculature.<ref>Knife-edge scanning microscope (KESM): http://research.cs.tamu.edu/bnl/kesm.html</ref>
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[[Category:Microscopes]]