View source for L1TD1

{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{Infobox_gene}}
'''LINE-1 type transposase domain containing 1''', also known as '''L1TD1''', is an [[RNA-binding protein]] that involved with self-renewal of undifferentiated human [[embryonic stem cell]]s and [[cancer cell]] proliferation.  L1TD1 has been reported to associate with the development of several [[cancer]]s.
<ref name="pmid21637830">
{{
cite journal |vauthors=Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S |
title = ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency |
journal = PLOS ONE |
volume = 6 |
issue = 5 |
pages = e20461 |date=May 2011 |
pmid = 21637830 |
doi = 10.1371/journal.pone.0020461 |
issn =
| pmc=3102727
|
bibcode = 2011PLoSO...620461I |
doi-access = free }}</ref>
<ref name="pmid22162396">
{{
cite journal |vauthors=Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R |
title = RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation |
journal = Stem Cells |
volume = 30 |
issue = 3 |
pages = 452–60 |date=March 2012 |
pmid = 22162396 |
doi = 10.1002/stem.1013 |
url = |
issn =
| pmc=3507993
}}</ref>
<ref name="pmid21559406">
{{
cite journal |vauthors=Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ |
title = L1TD1 is a marker for undifferentiated human embryonic stem cells |
journal = PLOS ONE |
volume = 6 |
issue = 4 |
pages = e19355 |date=April 2011 |
pmid = 21559406 |
doi = 10.1371/journal.pone.0019355 |
issn =
| pmc=3084827
|
bibcode = 2011PLoSO...619355W |
doi-access = free }}</ref>
<ref name="pmid18842996">
{{
cite journal |vauthors=Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y |
title = LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis |
journal = Cancer Epidemiol Biomarkers Prev |
volume = 17 |
issue = 10 |
pages = 2555–64 |date=October 2008 |
pmid = 18842996 |
doi = 10.1158/1055-9965.EPI-08-0112|
url = http://cebp.aacrjournals.org/content/17/10/2555.long |
issn =
|
doi-access =  |
s2cid = 24719399 }}</ref>
==References==
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==Further reading==
{{refbegin | 2}}
*{{cite journal   |vauthors=Mitsui K, Tokuzawa Y, Itoh H, etal |title=The homeoprotein Nanog isrequired for maintenance of pluripotency in mouse epiblast and ES cells |journal=Cell |volume=113 |issue= 5 |pages= 631–42 |year= 2003 |pmid= 12787504 |doi=10.1016/S0092-8674(03)00393-3|s2cid=18836242 |doi-access=free }}
*{{cite journal   |vauthors=Cash HL, Tao L, Yuan JM, etal |title=LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese |journal=Int J Cancer |volume=130 |issue= 5 |pages= 1151–9 |year= 2012 |pmid= 21445976 |doi = 10.1002/ijc.26098 |pmc=3208798}}
{{refend}}