View source for MED22

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Mediator of RNA polymerase II transcription subunit 22''' is an [[enzyme]] that in humans is encoded by the ''MED22'' [[gene]].<ref name="pmid8499913">{{cite journal | vauthors = Yon J, Jones T, Garson K, Sheer D, Fried M | title = The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1 | journal = Human Molecular Genetics | volume = 2 | issue = 3 | pages = 237–40 | date = Mar 1993 | pmid = 8499913 | doi = 10.1093/hmg/2.3.237 }}</ref><ref name="pmid15175163">{{cite journal | vauthors = Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC | title = A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology | journal = Molecular Cell | volume = 14 | issue = 5 | pages = 685–91 | date = Jun 2004 | pmid = 15175163 | doi = 10.1016/j.molcel.2004.05.006 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SURF5 surfeit 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6837}}</ref>
== Function ==
This gene is located in the [[surfeit]] gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez" />
== Interactions ==
MED22 has been shown to [[Protein-protein interaction|interact]] with [[MED30]].<ref name=pmid12584197>{{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW | title = Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15123–7 | date = Apr 2003 | pmid = 12584197 | doi = 10.1074/jbc.C300054200 | doi-access = free }}</ref>
== References ==
{{reflist|33em}}
== Further reading ==
{{refbegin|33em}}
* {{cite journal | vauthors = De Falco S, Russo G, Angiolillo A, Pietropaolo C | title = Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene | journal = Gene | volume = 126 | issue = 2 | pages = 227–35 | date = Apr 1993 | pmid = 8482538 | doi = 10.1016/0378-1119(93)90371-9 }}
* {{cite journal | vauthors = Garson K, Duhig T, Armes N, Colombo P, Fried M | title = Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene | journal = Genomics | volume = 30 | issue = 2 | pages = 163–70 | date = Nov 1995 | pmid = 8586415 | doi = 10.1006/geno.1995.9889 }}
* {{cite journal | vauthors = Garson K, Duhig T, Fried M | title = Tissue-specific processing of the Surf-5 and Surf-4 mRNAs | journal = Gene Expression | volume = 6 | issue = 4 | pages = 209–18 | year = 1997 | pmid = 9196076 | pmc = 6148271 }}
* {{cite journal | vauthors = Duhig T, Ruhrberg C, Mor O, Fried M | title = The human Surfeit locus | journal = Genomics | volume = 52 | issue = 1 | pages = 72–8 | date = Aug 1998 | pmid = 9740673 | doi = 10.1006/geno.1998.5372 }}
* {{cite journal | vauthors = Angiolillo A, Russo G, Porcellini A, Smaldone S, D'Alessandro F, Pietropaolo C | title = The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts | journal = Gene | volume = 284 | issue = 1–2 | pages = 169–78 | date = Feb 2002 | pmid = 11891058 | doi = 10.1016/S0378-1119(02)00379-7 }}
* {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW | title = Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15123–7 | date = Apr 2003 | pmid = 12584197 | doi = 10.1074/jbc.C300054200 | doi-access = free }}
* {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW | title = A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 49671–4 | date = Dec 2003 | pmid = 14576168 | doi = 10.1074/jbc.C300444200 | doi-access = free }}
* {{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5846–51 | date = Feb 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 | doi-access = free }}
* {{cite journal | vauthors = Hillman RT, Green RE, Brenner SE | title = An unappreciated role for RNA surveillance | journal = Genome Biology | volume = 5 | issue = 2 | pages = R8 | year = 2005 | pmid = 14759258 | pmc = 395752 | doi = 10.1186/gb-2004-5-2-r8 | doi-access = free }}
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