View source for MIR106A

{{Short description|Non-coding RNA in the species Homo sapiens}}
{{Infobox_gene}}
'''MicroRNA 106a''' is a microRNA that in humans is encoded by the MIR106A [[gene]].
<ref name="entrez">
{{cite web
| title = Entrez Gene: MicroRNA 106a
| url = https://www.ncbi.nlm.nih.gov/gene/406899
| access-date = 2017-11-13
}}</ref>
==Function==
[[MicroRNA|microRNAs]] (miRNAs) are short (20-24 nt) non-coding [[RNA|RNAs]] that are involved in post-transcriptional regulation of [[gene expression]] in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by [[RNA polymerase II]] as part of capped and [[Polyadenylation|polyadenylated]] primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.
The primary transcript is cleaved by the [[Drosha ribonuclease III]] enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic [[Dicer ribonuclease]] to generate the mature miRNA and antisense miRNA star (miRNA*) products.
The mature miRNA is incorporated into a [[RNA-induced silencing complex]] (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
== References ==
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== Further reading ==
{{refbegin | 2}}
*{{cite journal |vauthors=Sharma A, Kumar M, Aich J, Hariharan M, Brahmachari SK, Agrawal A, Ghosh B |title=Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=106 |issue=14 |pages=5761–6 |year=2009 |pmid=19307576 |pmc=2659714 |doi=10.1073/pnas.0808743106 |bibcode=2009PNAS..106.5761S |doi-access=free }}
*{{cite journal |vauthors=Hackl M, Brunner S, Fortschegger K, Schreiner C, Micutkova L, Mück C, Laschober GT, Lepperdinger G, Sampson N, Berger P, Herndler-Brandstetter D, Wieser M, Kühnel H, Strasser A, Rinnerthaler M, Breitenbach M, Mildner M, Eckhart L, Tschachler E, Trost A, Bauer JW, Papak C, Trajanoski Z, Scheideler M, Grillari-Voglauer R, Grubeck-Loebenstein B, Jansen-Dürr P, Grillari J |title=miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging |journal=Aging Cell |volume=9 |issue=2 |pages=291–6 |year=2010 |pmid=20089119 |pmc=2848978 |doi=10.1111/j.1474-9726.2010.00549.x }}
*{{cite journal |vauthors=Zhou H, Guo JM, Lou YR, Zhang XJ, Zhong FD, Jiang Z, Cheng J, Xiao BX |title=Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker |journal=J. Mol. Med. |volume=88 |issue=7 |pages=709–17 |year=2010 |pmid=20349219 |doi=10.1007/s00109-010-0617-2 |s2cid=13285873 }}
*{{cite journal |vauthors=Hummel R, Hussey DJ, Michael MZ, Haier J, Bruewer M, Senninger N, Watson DI |title=MiRNAs and their association with locoregional staging and survival following surgery for esophageal carcinoma |journal=Ann. Surg. Oncol. |volume=18 |issue=1 |pages=253–60 |year=2011 |pmid=20628822 |doi=10.1245/s10434-010-1213-y |s2cid=26439245 }}
*{{cite journal |vauthors=Jiang X, Li N |title=Induction of MiR-17-3p and MiR-106a [corrected] by TNFα and LPS |journal=Cell Biochem. Funct. |volume=29 |issue=2 |pages=164–70 |year=2011 |pmid=21370248 |doi=10.1002/cbf.1728 |s2cid=26310852 }}
*{{cite journal |vauthors=Liao B, Bao X, Liu L, Feng S, Zovoilis A, Liu W, Xue Y, Cai J, Guo X, Qin B, Zhang R, Wu J, Lai L, Teng M, Niu L, Zhang B, Esteban MA, Pei D |title=MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition |journal=J. Biol. Chem. |volume=286 |issue=19 |pages=17359–64 |year=2011 |pmid=21454525 |pmc=3089577 |doi=10.1074/jbc.C111.235960 |doi-access=free }}
*{{cite journal |vauthors=Yang G, Zhang R, Chen X, Mu Y, Ai J, Shi C, Liu Y, Shi C, Sun L, Rainov NG, Li H, Yang B, Zhao S |title=MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status |journal=J. Mol. Med. |volume=89 |issue=10 |pages=1037–50 |year=2011 |pmid=21656380 |doi=10.1007/s00109-011-0775-x |s2cid=26039378 |url=https://figshare.com/articles/journal_contribution/10769768 }}
*{{cite journal |vauthors=Wang Z, Liu M, Zhu H, Zhang W, He S, Hu C, Quan L, Bai J, Xu N |title=miR-106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS |journal=Mol. Carcinog. |volume=52 |issue=8 |pages=634–46 |year=2013 |pmid=22431000 |doi=10.1002/mc.21899 |s2cid=22089497 }}
*{{cite journal |vauthors=Feng B, Dong TT, Wang LL, Zhou HM, Zhao HC, Dong F, Zheng MH |title=Colorectal cancer migration and invasion initiated by microRNA-106a |journal=PLOS ONE |volume=7 |issue=8 |pages=e43452 |year=2012 |pmid=22912877 |pmc=3422256 |doi=10.1371/journal.pone.0043452 |bibcode=2012PLoSO...743452F |doi-access=free }}
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