View source for MLL4

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Myeloid/lymphoid or mixed-lineage leukemia 4''', also known as '''MLL4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MLL4 myeloid/lymphoid or mixed-lineage leukemia 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9757| accessdate = }}</ref>
This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.<ref name="entrez" />
==References==
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==Further reading==
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*{{cite journal  |vauthors=Bedford MT, Chan DC, Leder P |title=FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands |journal=EMBO J. |volume=16 |issue= 9 |pages= 2376–83 |year= 1997 |pmid= 9171351 |doi= 10.1093/emboj/16.9.2376  | pmc=1169838 }}
*{{cite journal   |vauthors=Nagase T, Ishikawa K, Nakajima D, etal |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=10.1093/dnares/4.2.141  |doi-access=free }}
*{{cite journal  |vauthors=FitzGerald KT, Diaz MO |title=MLL2: A new mammalian member of the trx/MLL family of genes |journal=Genomics |volume=59 |issue= 2 |pages= 187–92 |year= 1999 |pmid= 10409430 |doi= 10.1006/geno.1999.5860 }}
*{{cite journal   |vauthors=Huntsman DG, Chin SF, Muleris M, etal |title=MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines |journal=Oncogene |volume=18 |issue= 56 |pages= 7975–84 |year= 2000 |pmid= 10637508 |doi= 10.1038/sj.onc.1203291 |doi-access= free }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |doi-access= free }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |doi-access=free }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
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== External links ==
* {{MeshName|MLL4+protein,+human}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{gene-19-stub}}