View source for Mir-148/mir-152 microRNA precursor family

{{Infobox rfam
| Name = mir-148/mir-152 microRNA precursor family
| image = RF00248.jpg
| width =
| caption = Predicted [[secondary structure]] and [[sequence conservation]] of mir-148
| Symbol = mir-148
| AltSymbols =
| Rfam = RF00248
| miRBase = MI0000253
| miRBase_family = MIPF0000056
| RNA_type = [[Gene]]; [[MicroRNA|miRNA]]
| Tax_domain = [[Eukaryota]]
| GO = {{GO|0035195}} {{GO|0035068}}
| SO = {{SO|0001244}}
| CAS_number =
| EntrezGene =
| HGNCid =
| OMIM =
| PDB =
| RefSeq =
| Chromosome =
| Arm =
| Band =
| LocusSupplementaryData =
}}
In [[molecular biology]], '''miR-148''' is a [[microRNA]] whose expression has been demonstrated in [[human]] ([https://web.archive.org/web/20070929110504/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000253 MI0000253]), [[mouse]] ([https://archive.today/20121223221908/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000550 MI0000550]), [[rat]] ([https://web.archive.org/web/20070929105009/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000616 MI0000616]) and [[zebrafish]] ([https://archive.today/20121225010144/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0002015 MI0002015]).<ref name="lagos_2002" >{{cite journal | last = Lagos-Quintana | first = M |author2=Rauhut R |author3=Yalcin A |author4=Meyer J |author5=Lendeckel W |author6=Tuschl T  | year = 2002 | title = Identification of tissue-specific microRNAs from mouse | journal = Curr Biol | volume = 12 | pages = 735&ndash;739 | pmid = 12007417 | doi = 10.1016/S0960-9822(02)00809-6 | issue = 9| hdl = 11858/00-001M-0000-0010-94EF-7 | s2cid = 7901788 | hdl-access = free }}</ref><ref>{{cite journal | last = Kim | first = J |author2=Krichevsky A |author3=Grad Y |author4=Hayes GD |author5=Kosik KS |author6=Church GM |author7=Ruvkun G  | year = 2004 | title = Identification of many microRNAs that copurify with polyribosomes in mammalian neurons | journal = Proc Natl Acad Sci USA | volume = 101 | pages = 360&ndash;365 | pmid = 14691248 | doi = 10.1073/pnas.2333854100 | issue = 1 | pmc = 314190 | bibcode=2004PNAS..101..360K| doi-access = free }}</ref><ref>{{cite journal | last = Chen | first = PY |author2=Manninga H |author3=Slanchev K |author4=Chien M |author5=Russo JJ |author6=Ju J |author7=Sheridan R |author8=John B |author9=Marks DS |author10=Gaidatzis D |author11=Sander C |author12=Zavolan M |author13=Tuschl T | year = 2005 | title = The developmental miRNA profiles of zebrafish as determined by small RNA cloning | journal = Genes Dev. | volume = 19 | pages = 1288&ndash;1293 | pmid = 15937218 | doi = 10.1101/gad.1310605 | issue = 11 | pmc = 1142552}}</ref>  miR-148 has also been predicted in [[chicken]] ([https://archive.today/20121223065603/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0001189 MI0001189]).
These predicted hairpin precursor sequence are related to those of miR-152, which has been expressed in mouse ([https://web.archive.org/web/20070926215656/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000174 MI0000174]) and is predicted in human ([https://web.archive.org/web/20070929093212/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000462 MI0000462]).<ref name="lagos_2002" />
The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known.  In this case, the mature sequence is excised from the 3' arm of the [[stem-loop|hairpin]].
==Targets of miR-148==
MicroRNAs act by lowering the expression of genes by binding to target sites in the [[3' UTR]] of the mRNAs. However recently it was shown by Duursma and colleagues that miR-148 down regulates [[Dnmt3b]] by binding to a region in the protein coding region.<ref name="pmid18367714">{{cite journal |vauthors=Duursma AM, Kedde M, Schrier M, le Sage C, Agami R |title=miR-148 targets human DNMT3b protein coding region |journal=RNA |volume=14 |issue=5 |pages=872–7 |date=May 2008 |pmid=18367714 |doi=10.1261/rna.972008 |pmc=2327368}}</ref>
==References==
{{reflist}}
==External links==
* {{Rfam|id=RF00248|name=miR-148/miR-152 microRNA precursor family}}
* [https://archive.today/20121223152300/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000056 miRBase family page]
{{miRNA precursor families}}
{{DEFAULTSORT:Mir-148 mir-152 microRNA precursor family}}
[[Category:MicroRNA]]
[[Category:MicroRNA precursor families]]
{{molecular-cell-biology-stub}}