View source for NCR1

{{Short description|Mammalian protein found in Homo sapiens}}
{{Infobox_gene}}
'''Natural cytotoxicity triggering receptor 1''' is a [[protein]] that in humans is encoded by the ''NCR1'' [[gene]].<ref name="pmid9730896">{{cite journal |vauthors=Pessino A, Sivori S, Bottino C, Malaspina A, Morelli L, Moretta L, Biassoni R, Moretta A | title = Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity | journal = J Exp Med | volume = 188 | issue = 5 | pages = 953–60 |date=Sep 1998 | pmid = 9730896 | pmc =  3207313| doi =10.1084/jem.188.5.953  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9437}}</ref> NCR1 has also been designated as '''CD335''' ([[cluster of differentiation]], ''' NKP46, NKp46, NK-p46,''' and '''LY94'''.<ref>{{Cite web | url=https://www.ncbi.nlm.nih.gov/gene/9437 |title = NCR1 natural cytotoxicity triggering receptor 1 &#91;Homo sapiens (human)&#93; - Gene - NCBI}}</ref>
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  | author=Biassoni R |title=Human natural killer cell receptors: insights into their molecular function and structure |journal=J. Cell. Mol. Med. |volume=7 |issue= 4 |pages= 376–87 |year= 2004 |pmid= 14754506 |doi=10.1111/j.1582-4934.2003.tb00240.x  |name-list-style=vanc| author2=Cantoni C  | author3=Marras D  | display-authors=3  | last4=Giron-Michel  | first4=J.  | last5=Falco  | first5=Michela  | last6=Moretta  | first6=L.  | last7=Dimasi  | first7=N.  | pmc=6740120  }}
*{{cite journal  | author=Sivori S |title=p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation |journal=J. Exp. Med. |volume=186 |issue= 7 |pages= 1129–36 |year= 1997 |pmid= 9314561 |doi=10.1084/jem.186.7.1129  | pmc=2211712  |name-list-style=vanc| author2=Vitale M  | author3=Morelli L  | display-authors=3  | last4=Sanseverino  | first4=L  | last5=Augugliaro  | first5=R  | last6=Bottino  | first6=C  | last7=Moretta  | first7=L  | last8=Moretta  | first8=A  }}
*{{cite journal  | author=Vitale M |title=NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis |journal=J. Exp. Med. |volume=187 |issue= 12 |pages= 2065–72 |year= 1998 |pmid= 9625766 |doi=10.1084/jem.187.12.2065  | pmc=2212362  |name-list-style=vanc| author2=Bottino C  | author3=Sivori S  | display-authors=3  | last4=Sanseverino  | first4=L  | last5=Castriconi  | first5=R  | last6=Marcenaro  | first6=E  | last7=Augugliaro  | first7=R  | last8=Moretta  | first8=L  | last9=Moretta  | first9=A  }}
*{{cite journal  | author=Cantoni C |title=NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily |journal=J. Exp. Med. |volume=189 |issue= 5 |pages= 787–96 |year= 1999 |pmid= 10049942 |doi=10.1084/jem.189.5.787  | pmc=2192947  |name-list-style=vanc| author2=Bottino C  | author3=Vitale M  | display-authors=3  | last4=Pessino  | first4=A  | last5=Augugliaro  | first5=R  | last6=Malaspina  | first6=A  | last7=Parolini  | first7=S  | last8=Moretta  | first8=L  | last9=Moretta  | first9=A  }}
*{{cite journal  | author=Vankayalapati R |title=The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3451–7 |year= 2002 |pmid= 11907104 |doi=  10.4049/jimmunol.168.7.3451|name-list-style=vanc| author2=Wizel B  | author3=Weis SE  | display-authors=3  | last4=Safi  | first4=H  | last5=Lakey  | first5=DL  | last6=Mandelboim  | first6=O  | last7=Samten  | first7=B  | last8=Porgador  | first8=A  | last9=Barnes  | first9=PF  | doi-access=free  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-style=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  | author=Augugliaro R |title=Selective cross-talk among natural cytotoxicity receptors in human natural killer cells |journal=Eur. J. Immunol. |volume=33 |issue= 5 |pages= 1235–41 |year= 2003 |pmid= 12731048 |doi= 10.1002/eji.200323896  |name-list-style=vanc| author2=Parolini S  | author3=Castriconi R  | display-authors=3  | last4=Marcenaro  | first4=Emanuela  | last5=Cantoni  | first5=Claudia  | last6=Nanni  | first6=Marina  | last7=Moretta  | first7=Lorenzo  | last8=Moretta  | first8=Alessandro  | last9=Bottino  | first9=Cristina |s2cid=10724743 | doi-access=free  }}
*{{cite journal  | author=Ponassi M |title=Structure of the human NK cell triggering receptor NKp46 ectodomain |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 2 |pages= 317–23 |year= 2003 |pmid= 12951052 |doi=10.1016/j.bbrc.2003.08.007  |name-list-style=vanc| author2=Cantoni C  | author3=Biassoni R  | display-authors=3  | last4=Conte  | first4=Romana  | last5=Spallarossa  | first5=Andrea  | last6=Pesce  | first6=Alessandra  | last7=Moretta  | first7=Alessandro  | last8=Moretta  | first8=Lorenzo  | last9=Bolognesi  | first9=Martino  }}
*{{cite journal  |vauthors=Foster CE, Colonna M, Sun PD |title=Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors |journal=J. Biol. Chem. |volume=278 |issue= 46 |pages= 46081–6 |year= 2003 |pmid= 12960161 |doi= 10.1074/jbc.M308491200 |doi-access= free }}
*{{cite journal  | author=Arnon TI |title=The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46 |journal=Blood |volume=103 |issue= 2 |pages= 664–72 |year= 2004 |pmid= 14504081 |doi= 10.1182/blood-2003-05-1716  |name-list-style=vanc| author2=Achdout H  | author3=Lieberman N  | display-authors=3  | last4=Gazit  | first4=R  | last5=Gonen-Gross  | first5=T  | last6=Katz  | first6=G  | last7=Bar-Ilan  | first7=A  | last8=Bloushtain  | first8=N  | last9=Lev  | first9=M | doi-access=free  }}
*{{cite journal  | author=Marcenaro E |title=CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity |journal=Eur. J. Immunol. |volume=33 |issue= 12 |pages= 3367–76 |year= 2004 |pmid= 14635045 |doi= 10.1002/eji.200324425  |name-list-style=vanc| author2=Augugliaro R  | author3=Falco M  | display-authors=3  | last4=Castriconi  | first4=Roberta  | last5=Parolini  | first5=Silvia  | last6=Sivori  | first6=Simona  | last7=Romeo  | first7=Elisa  | last8=Millo  | first8=Romano  | last9=Moretta  | first9=Lorenzo |s2cid=40345630 | doi-access=free  }}
*{{cite journal  | author=Carbone E |title=HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells |journal=Blood |volume=105 |issue= 1 |pages= 251–8 |year= 2005 |pmid= 15328155 |doi= 10.1182/blood-2004-04-1422  |name-list-style=vanc| author2=Neri P  | author3=Mesuraca M  | display-authors=3  | last4=Fulciniti  | first4=MT  | last5=Otsuki  | first5=T  | last6=Pende  | first6=D  | last7=Groh  | first7=V  | last8=Spies  | first8=T  | last9=Pollio  | first9=G | doi-access=free  }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-style=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  |vauthors=Mavoungou E, Bouyou-Akotet MK, Kremsner PG |title=Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30) |journal=Clin. Exp. Immunol. |volume=139 |issue= 2 |pages= 287–96 |year= 2005 |pmid= 15654827 |doi= 10.1111/j.1365-2249.2004.02686.x  | pmc=1809301 }}
*{{cite journal  | author=Nowbakht P |title=Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias |journal=Blood |volume=105 |issue= 9 |pages= 3615–22 |year= 2005 |pmid= 15657183 |doi= 10.1182/blood-2004-07-2585  |name-list-style=vanc| author2=Ionescu MC  | author3=Rohner A  | display-authors=3  | last4=Kalberer  | first4=CP  | last5=Rossy  | first5=E  | last6=Mori  | first6=L  | last7=Cosman  | first7=D  | last8=De Libero  | first8=G  | last9=Wodnar-Filipowicz  | first9=A | doi-access=free  }}
*{{cite journal  | author=Poggi A |title=Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors |journal=J. Immunol. |volume=174 |issue= 5 |pages= 2653–60 |year= 2005 |pmid= 15728472 |doi=  10.4049/jimmunol.174.5.2653|name-list-style=vanc| author2=Massaro AM  | author3=Negrini S  | display-authors=3  | last4=Contini  | first4=P  | last5=Zocchi  | first5=MR  |doi-access=free}}
*{{cite journal  | author=Zilka A |title=Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46 |journal=Biochemistry |volume=44 |issue= 44 |pages= 14477–85 |year= 2006 |pmid= 16262248 |doi= 10.1021/bi051241s  |name-list-style=vanc| author2=Landau G  | author3=Hershkovitz O  | display-authors=3  | last4=Bloushtain  | first4=Noga  | last5=Bar-Ilan  | first5=Ahuva  | last6=Benchetrit  | first6=Fabrice  | last7=Fima  | first7=Eyal  | last8=Van Kuppevelt  | first8=Toin H.  | last9=Gallagher  | first9=John T. }}
*{{cite journal  | author=Hermann E |title=Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells |journal=Pediatr. Res. |volume=60 |issue= 1 |pages= 38–43 |year= 2006 |pmid= 16690951 |doi= 10.1203/01.pdr.0000220335.05588.ea  |name-list-style=vanc| author2=Alonso-Vega C  | author3=Berthe A  | display-authors=3  | last4=Truyens  | first4=Carine  | last5=Flores  | first5=Amilcar  | last6=Cordova  | first6=Marisol  | last7=Moretta  | first7=Lorenzo  | last8=Torrico  | first8=Faustino  | last9=Braud  | first9=Veronique | doi-access=free  }}
{{refend}}
==External links==
* {{MeshName|NCR1+protein,+human}}
* {{PDBe-KB2|O76036|Natural cytotoxicity triggering receptor 1}}
{{PDB Gallery|geneid=9437}}
{{Clusters of differentiation}}
{{DEFAULTSORT:Ncr1}}
[[Category:Clusters of differentiation]]
[[Category:Human proteins]]