View source for NDFIP1

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Nedd4 family interacting protein 1''' is a [[protein]] that in humans is encoded by the NDFIP1 [[gene]].
<ref name="entrez">
{{cite web
| title = Entrez Gene: Nedd4 family interacting protein 1
| url = https://www.ncbi.nlm.nih.gov/gene/80762
| access-date = 2017-10-18
}}</ref>
==Function==
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008].
== References ==
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== Further reading ==
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*{{cite journal |vauthors=Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, Tan SS |title=Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins |journal=J. Biol. Chem. |volume=283 |issue=47 |pages=32621–7 |year=2008 |pmid=18819914 |doi=10.1074/jbc.M804120200 |doi-access=free }}
*{{cite journal |vauthors=Mund T, Pelham HR |title=Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins |journal=EMBO Rep. |volume=10 |issue=5 |pages=501–7 |year=2009 |pmid=19343052 |pmc=2680872 |doi=10.1038/embor.2009.30 }}
*{{cite journal |vauthors=Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS |title=Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=106 |issue=36 |pages=15489–94 |year=2009 |pmid=19706893 |pmc=2741278 |doi=10.1073/pnas.0904880106 |bibcode=2009PNAS..10615489H |doi-access=free }}
*{{cite journal |vauthors=Mund T, Pelham HR |title=Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=107 |issue=25 |pages=11429–34 |year=2010 |pmid=20534535 |pmc=2895104 |doi=10.1073/pnas.0911714107 |bibcode=2010PNAS..10711429M |doi-access=free }}
*{{cite journal |vauthors=Schieber C, Howitt J, Putz U, White JM, Parish CL, Donnelly PS, Tan SS |title=Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes |journal=J. Biol. Chem. |volume=286 |issue=10 |pages=8555–64 |year=2011 |pmid=21187286 |pmc=3048738 |doi=10.1074/jbc.M110.203448 |doi-access=free }}
*{{cite journal |vauthors=Wang Y, Tong X, Ye X |title=Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation |journal=J. Immunol. |volume=189 |issue=11 |pages=5304–13 |year=2012 |pmid=23087404 |doi=10.4049/jimmunol.1201445 |doi-access=free }}
*{{cite journal |vauthors=Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS |title=Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels |journal=PLOS ONE |volume=9 |issue=1 |pages=e87119 |year=2014 |pmid=24475238 |pmc=3901732 |doi=10.1371/journal.pone.0087119 |bibcode=2014PLoSO...987119H |doi-access=free }}
*{{cite journal |vauthors=Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS |title=Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response |journal=J. Biol. Chem. |volume=290 |issue=11 |pages=7141–50 |year=2015 |pmid=25631046 |pmc=4358134 |doi=10.1074/jbc.M114.613687 |doi-access=free }}
*{{cite journal |vauthors=Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y |title=Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells |journal=Biochem. Biophys. Res. Commun. |volume=465 |issue=4 |pages=851–6 |year=2015 |pmid=26319551 |doi=10.1016/j.bbrc.2015.08.099 }}
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