View source for OR1A2

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Olfactory receptor 1A2''' is a [[protein]] that in humans is encoded by the ''OR1A2'' [[gene]].<ref name="pmid10673334">{{cite journal | vauthors = Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D | title = Sequence, structure, and evolution of a complete human olfactory receptor gene cluster | journal = Genomics | volume = 63 | issue = 2 | pages = 227–45 |date=Apr 2000 | pmid = 10673334 | doi = 10.1006/geno.1999.6030 | s2cid = 23416814 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OR1A2 olfactory receptor, family 1, subfamily A, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26189}}</ref>
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez" />
==Ligands==
The known ligands of OR1A2 are near-identical to those of [[OR1A1]].<ref name="pmid17601748">{{cite journal | vauthors = Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D | title = Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2 | journal = Journal of Structural Biology | volume = 159 | issue = 3 | pages = 400–12 | date = September 2007 | pmid = 17601748 | doi = 10.1016/j.jsb.2007.04.013 }}</ref> Examples of known ligands, most of which have citrus or fruity smells:<ref name="pmid17601748"/><ref name="pmid24695519">{{cite journal | vauthors = Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, Brunak S, Taboureau O | display-authors = 6 | title = Identification of odorant-receptor interactions by global mapping of the human odorome | journal = PLOS ONE | volume = 9 | issue = 4 | pages = e93037 | date = 2014 | pmid = 24695519 | pmc = 3973694 | doi = 10.1371/journal.pone.0093037 | bibcode = 2014PLoSO...993037A | doi-access = free }}</ref>
* (S)-(−)-[[citronellal]]
* [[Helional]]
* [[Heptanal]]
* [[Octanal]]
* [[Nonanal]] (weaker than heptanal/octanal<ref name="pmid17601748"/>)
* [[Hydroxycitronellal]]
* [[Citral]]
* (S)-(−)-[[Citronellol]] (in contrast to [[OR1A1]] only this enantiomer is effective; weaker than citronellal<ref name="pmid17601748"/>)
==See also==
* [[Olfactory receptor]]
==Notes==
{{reflist}}
==References==
* {{NLM content}}
==Further reading==
{{refbegin | 2}}
*{{cite journal   |vauthors=Fuchs T, Malecova B, Linhart C, etal |title=DEFOG: a practical scheme for deciphering families of genes |journal=Genomics |volume=80 |issue= 3 |pages= 295–302 |year= 2003 |pmid= 12213199 |doi=10.1006/geno.2002.6830  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 |bibcode=2004PNAS..101.2584M |doi-access=free }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
{{refend}}
== External links ==
* {{MeshName|OR1A2+protein,+human}}
{{Olfactory receptors}}
[[Category:Olfactory receptors]]