View source for OR51E1

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Olfactory receptor 51E1''' is a [[protein]] that in humans is encoded by the ''OR51E1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR51E1 olfactory receptor, family 51, subfamily E, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=143503}}</ref>
[[Olfactory]] receptors interact with [[odorant]] molecules in the nose, to initiate a [[neuron|neuronal response]] that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of [[G-protein-coupled receptors]] arising from single coding-[[exon]] genes. Olfactory receptors share a 7-[[transmembrane]] [[protein domain|domain]] structure with many neurotransmitter and [[hormone receptors]] and are responsible for the [[molecular recognition|recognition]] and G protein-mediated transduction of odorant signals. The olfactory receptor [[gene family]] is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez" />
==Ligands==
The receptor is associated with some compounds with a "cheese" or "sour" scent note.
Examples of compounds that activate OR51E1 include:
* [[butyl butyryl lactate]]<ref name="pmid19261596">{{cite journal | vauthors = Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD | title = Odor coding by a Mammalian receptor repertoire | journal = Science Signaling | volume = 2 | issue = 60 | pages = ra9 | date = March 2009 | pmid = 19261596 | pmc = 2774247 | doi = 10.1126/scisignal.2000016 }}</ref>
* [[isovaleric acid]]<ref name="renamed_from_24316890_on_20200420052639">{{cite journal | vauthors = Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, Moberly AH, Adipietro KA, Liu WL, Zhuang H, Zhan S, Lee SS, Lin A, Matsunami H | display-authors = 6 | title = The missense of smell: functional variability in the human odorant receptor repertoire | journal = Nature Neuroscience | volume = 17 | issue = 1 | pages = 114–20 | date = January 2014 | pmid = 24316890 | doi = 10.1038/nn.3598 | pmc = 3990440 }}</ref>
* [[nonanoic acid]]<ref name="pmid19261596"/>
* [[3-methylpentanoic acid]]<ref name="pmid17885925">{{cite journal | vauthors = Fujita Y, Takahashi T, Suzuki A, Kawashima K, Nara F, Koishi R | title = Deorphanization of Dresden G protein-coupled receptor for an odorant receptor | journal = Journal of Receptor and Signal Transduction Research | volume = 27 | issue = 4 | pages = 323–34 | date = 2007 | pmid = 17885925 | doi = 10.1080/10799890701534180 | s2cid = 42999502 }}</ref>
* [[4-methylpentanoic acid]]<ref name="pmid17885925"/>
The following are in decreasing order of activity:<ref name="pmid22807691">{{cite journal | vauthors = Adipietro KA, Mainland JD, Matsunami H | title = Functional evolution of mammalian odorant receptors | journal = PLOS Genetics | volume = 8 | issue = 7 | pages = e1002821 | date = 2012 | pmid = 22807691 | pmc = 3395614 | doi = 10.1371/journal.pgen.1002821 | doi-access = free }}</ref>
* [[butyric acid]]
* [[methyl eugenol]]
* [[methyl salicylate]]
* [[(+)-menthol]]
* [[eugenyl acetate]]
* [[2,4-dinitrotoluene]]
* [[pyrazine]]
* [[dimethyl disulfide]]
* [[methyl furfuryl disulfide]]
* [[pentanol]]
* [[propanal]]
== See also ==
* [[Olfactory receptor]]
== References ==
{{reflist}}
== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Wang J, Weng J, Cai Y, Penland R, Liu M, Ittmann M | title = The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase | journal = The Prostate | volume = 66 | issue = 8 | pages = 847–57 | date = June 2006 | pmid = 16491480 | doi = 10.1002/pros.20389 | s2cid = 25548828 }}
* {{cite journal | vauthors = Weng J, Wang J, Hu X, Wang F, Ittmann M, Liu M | title = PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer | journal = International Journal of Cancer | volume = 118 | issue = 6 | pages = 1471–80 | date = March 2006 | pmid = 16206286 | doi = 10.1002/ijc.21527 | s2cid = 23711956 }}
* {{cite journal | vauthors = Weigle B, Fuessel S, Ebner R, Temme A, Schmitz M, Schwind S, Kiessling A, Rieger MA, Meye A, Bachmann M, Wirth MP, Rieber EP | display-authors = 6 | title = D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate | journal = Biochemical and Biophysical Research Communications | volume = 322 | issue = 1 | pages = 239–49 | date = September 2004 | pmid = 15313197 | doi = 10.1016/j.bbrc.2004.07.106 }}
* {{cite journal | vauthors = Malnic B, Godfrey PA, Buck LB | title = The human olfactory receptor gene family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 8 | pages = 2584–9 | date = February 2004 | pmid = 14983052 | pmc = 356993 | doi = 10.1073/pnas.0307882100 | bibcode = 2004PNAS..101.2584M | doi-access = free }}
* {{cite journal | vauthors = Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF | title = Novel human G-protein-coupled receptors | journal = Biochemical and Biophysical Research Communications | volume = 305 | issue = 1 | pages = 67–71 | date = May 2003 | pmid = 12732197 | doi = 10.1016/S0006-291X(03)00709-5 }}
* {{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | display-authors = 6 | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | date = September 1995 | pmid = 7566098 | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf }}
{{refend}}
== External links ==
* {{MeshName|OR51E1+protein,+human}}
{{NLM content}}
{{Olfactory receptors}}
[[Category:Olfactory receptors]]