View source for Oxidoreductase FAD-binding domain

{{Pfam_box
| Symbol = FAD_binding_6
| Name = Oxidoreductase FAD-binding domain
| image =
| width =
| caption =
| Pfam= PF00970
| InterPro= IPR008333
| SMART=
| Prosite =
| SCOP = 1cne
| TCDB =
| OPM family=
| OPM protein=
| CDD = cd00322
| PDB=
{{PDB3|1ep1}}B:7-104     {{PDB3|1ep3}}B:7-104     {{PDB3|1ep2}}B:7-104
{{PDB3|1cqx}}A:156-261   {{PDB3|1gvh}}A:154-253   {{PDB3|1krh}}B:120-215
{{PDB3|2pia}} :11-108    {{PDB3|2bgi}}A:18-114    {{PDB3|2bgj}}B:18-114
{{PDB3|1a8p}} :6-101     {{PDB3|1fdr}}A:6-92      {{PDB3|1cnf}} :365-472
{{PDB3|2cnd}} :365-472   {{PDB3|1cne}} :365-472   {{PDB3|1m91}}A:44-151
{{PDB3|1umk}}A:44-151    {{PDB3|1ndh}} :15-122    {{PDB3|1i7p}}A:44-151
{{PDB3|1ib0}}A:44-151    {{PDB3|1qx4}}B:44-151
}}
The '''oxidoreductase FAD-binding domain ''' is an evolutionary conserved [[protein domain]]. To date, the 3D-structures of the flavoprotein domain of Zea mays nitrate reductase<ref name="PUB00005247">{{cite journal |vauthors=Lindqvist Y, Schneider G, Campbell WH, Lu G |title=Crystal structure of the FAD-containing fragment of corn nitrate reductase at 2.5 A resolution: relationship to other flavoprotein reductases |journal=Structure |volume=2 |issue=9 |pages=809–821 |year=1994 |pmid=7812715 |doi=10.1016/s0969-2126(94)00082-4|doi-access=free }}</ref> and of pig NADH:cytochrome b5 reductase<ref name="PUB00000415">{{cite journal |vauthors=Miki K, Nishida H, Inaka K, Yamanaka M, Kaida S, Kobayashi K |title=Crystal structure of NADH-cytochrome b5 reductase from pig liver at 2.4 A resolution |journal=Biochemistry |volume=34 |issue=9 |pages=2763–2767 |year=1995 |pmid=7893687 |doi=10.1021/bi00009a004}}</ref> have been solved. The overall fold is similar to that of ferredoxin:NADP<sup>+</sup> reductase:<ref name="PUB00002370">{{cite journal |vauthors=Karplus PA, Bruns CM |title=Structure-function relations for ferredoxin reductase |journal=J. Bioenerg. Biomembr. |volume=26 |issue=1 |pages=89–99 |year=1994 |pmid=8027025 |doi=10.1007/BF00763221|s2cid=1004663 }}</ref> the FAD-binding domain (N-terminal) has the topology of an anti-parallel beta-barrel, while the NAD(P)-binding domain (C-terminal) has the topology of a classical pyridine dinucleotide-binding fold (i.e. a central parallel beta-sheet flanked by 2 helices on each side).
== Examples ==
Human genes encoding proteins containing this domain include:
* [[CYB5R1]]; [[CYB5R2]]; [[CYB5R4]]; [[CYB5RL]];
==References==
{{reflist|30em}}
{{InterPro content|IPR008333}}
[[Category:Protein domains]]
[[Category:Single-pass transmembrane proteins]]
{{membrane-protein-stub}}