View source for PAQR3

{{infobox gene}}
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'''Progestin and adipoQ receptor family member 3''' ('''PAQR3'''), or '''Raf Kinase Trapping to Golgi apparatus''' ('''RKTG''') is a [[protein]] that in humans is encoded by the '''''PAQR3''''' [[gene]].<ref name="Yu_2015">{{cite journal | vauthors = Yu X, Li Z, Chan MT, Wu WK | title = PAQR3: a novel tumor suppressor gene | journal = American Journal of Cancer Research | volume = 5 | issue = 9 | pages = 2562–2568 | date = 2015 | pmid = 26609468 | pmc = 4633890 | doi =  }}</ref> It is a member of the [[progestin and adipoQ receptor]] (PAQR) family.<ref name="TangHu2005">{{cite journal | vauthors = Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD | title = PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif | journal = Journal of Molecular Evolution | volume = 61 | issue = 3 | pages = 372–380 | date = September 2005 | pmid = 16044242 | doi = 10.1007/s00239-004-0375-2 | s2cid = 31473802 | bibcode = 2005JMolE..61..372T }}</ref>
PAQR3 is predicted to have seven transmembrane helices and to be localized to the [[Golgi Apparatus]].<ref>{{cite journal | vauthors = Luo X, Feng L, Jiang X, Xiao F, Wang Z, Feng GS, Chen Y | title = Characterization of the topology and functional domains of RKTG | journal = The Biochemical Journal | volume = 414 | issue = 3 | pages = 399–406 | date = September 2008 | pmid = 18547165 | doi = 10.1042/BJ20080948 }}</ref><ref>{{cite journal | vauthors = Feng L, Xie X, Ding Q, Luo X, He J, Fan F, Liu W, Wang Z, Chen Y | title = Spatial regulation of Raf kinase signaling by RKTG | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 36 | pages = 14348–14353 | date = September 2007 | pmid = 17724343 | doi = 10.1073/pnas.0701298104 | doi-access = free | pmc = 1964828 | bibcode = 2007PNAS..10414348F }}</ref> It functions as a [[tumor suppressor]] by negatively regulating tumor cell proliferation and migration by inhibiting [[Raf kinase]] and [[PI3K/AKT/mTOR_pathway|AKT pathway]].<ref>{{cite journal | vauthors = Xie X, Zhang Y, Jiang Y, Liu W, Ma H, Wang Z, Chen Y | title = Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse | journal = Carcinogenesis | volume = 29 | issue = 8 | pages = 1632–1638 | date = August 2008 | pmid = 18550569 | doi = 10.1093/carcin/bgn139 }}</ref><ref>{{cite journal | vauthors = Zhang Y, Jiang X, Qin X, Ye D, Yi Z, Liu M, Bai O, Liu W, Xie X, Wang Z, Fang J, Chen Y | title = RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma | journal = Oncogene | volume = 29 | issue = 39 | pages = 5404–5415 | date = September 2010 | pmid = 20603618 | doi = 10.1038/onc.2010.270 }}</ref><ref>{{cite journal | vauthors = Jiang Y, Xie X, Li Z, Wang Z, Zhang Y, Ling ZQ, Pan Y, Wang Z, Chen Y | title = Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition | journal = Cancer Research | volume = 71 | issue = 8 | pages = 2959–2968 | date = April 2011 | pmid = 21385899 | doi = 10.1158/0008-5472.CAN-10-4077 }}</ref><ref>{{cite journal | vauthors = Wang X, Li X, Fan F, Jiao S, Wang L, Zhu L, Pan Y, Wu G, Ling ZQ, Fang J, Chen Y | title = PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers | journal = Carcinogenesis | volume = 33 | issue = 11 | pages = 2228–2235 | date = November 2012 | pmid = 22828136 | doi = 10.1093/carcin/bgs245 }}</ref><ref>{{cite journal | vauthors = Fan F, Feng L, He J, Wang X, Jiang X, Zhang Y, Wang Z, Chen Y | title = RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells | journal = Carcinogenesis | volume = 29 | issue = 6 | pages = 1157–1163 | date = June 2008 | pmid = 18515281 | doi = 10.1093/carcin/bgn119 }}</ref> PAQR3 was also shown to modulate [[cholesterol]] [[homeostasis]] by anchoring the [[SREBP_cleavage-activating_protein|SCAP]]/[[Sterol_regulatory_element-binding_protein|SREBP]] complex to the Golgi under cholesterol depletion conditions.<ref>{{cite journal | vauthors = Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, Chen Y | title = PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus | journal = Nature Communications | volume = 6 | issue = 1 | pages = 8100 | date = August 2015 | pmid = 26311497 | doi = 10.1038/ncomms9100 | pmc = 4560833 | bibcode = 2015NatCo...6.8100X }}</ref>
== References ==
{{Reflist}}
{{Cell surface receptors}}
[[Category:7TM receptors]]
{{gene-4-stub}}