View source for PCDHB11

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Protocadherin beta-11''' is a [[protein]] that in humans is encoded by the ''PCDHB11'' [[gene]].<ref name="pmid10380929">{{cite journal | vauthors = Wu Q, Maniatis T | title = A striking organization of a large family of human neural cadherin-like cell adhesion genes | journal = Cell | volume = 97 | issue = 6 | pages = 779–90 |date=Jul 1999 | pmid = 10380929 | doi =10.1016/S0092-8674(00)80789-8  | s2cid = 6014717 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PCDHB11 protocadherin beta 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56125}}</ref>
This gene is a member of the [[protocadherin]] beta gene cluster, one of three related [[gene cluster|gene clusters]] tandemly linked on [[chromosome five]]. The gene clusters demonstrate an unusual genomic organization similar to that of [[B-cell]] and [[T-cell]] receptor gene clusters. The beta cluster contains 16 genes and 3 [[pseudogenes]], each encoding 6 extracellular [[cadherin]] domains and a [[cytoplasmic]] tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell [[adhesion protein|adhesion proteins]] are integral [[plasma membrane]] proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.<ref name="entrez" />
==References==
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==Further reading==
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*{{cite journal  | vauthors=Yagi T, Takeichi M |title=Cadherin superfamily genes: functions, genomic organization, and neurologic diversity |journal=Genes Dev. |volume=14 |issue= 10 |pages= 1169–80 |year= 2000 |pmid= 10817752 |doi=  10.1101/gad.14.10.1169|s2cid=44844497 |doi-access=free }}
*{{cite journal  | vauthors=Nollet F, Kools P, van Roy F |title=Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 551–72 |year= 2000 |pmid= 10835267 |doi= 10.1006/jmbi.2000.3777 }}
*{{cite journal  | vauthors=Frank M, Kemler R |title=Protocadherins |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 557–62 |year= 2003 |pmid= 12231349 |doi=10.1016/S0955-0674(02)00365-4  }}
*{{cite journal  | vauthors=Matsuyoshi N, Tanaka T, Toda K, Imamura S |title=Identification of novel cadherins expressed in human melanoma cells |journal=J. Invest. Dermatol. |volume=108 |issue= 6 |pages= 908–13 |year= 1997 |pmid= 9182820 |doi=10.1111/1523-1747.ep12292703  |doi-access=free }}
*{{cite journal  | vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397  | pmc=16203 |doi-access=free }}
*{{cite journal   |vauthors=Wu Q, Zhang T, Cheng JF, etal |title=Comparative DNA sequence analysis of mouse and human protocadherin gene clusters |journal=Genome Res. |volume=11 |issue= 3 |pages= 389–404 |year= 2001 |pmid= 11230163 |doi= 10.1101/gr.167301  | pmc=311048 }}
*{{cite journal  | vauthors=Vanhalst K, Kools P, Vanden Eynde E, van Roy F |title=The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number |journal=FEBS Lett. |volume=495 |issue= 1–2 |pages= 120–5 |year= 2001 |pmid= 11322959 |doi=10.1016/S0014-5793(01)02372-9  |s2cid=36671435 |doi-access=free }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
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