View source for PCDHB15

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Protocadherin beta-15''' is a [[protein]] that in humans is encoded by the ''PCDHB15'' [[gene]].<ref name="pmid10380929">{{cite journal | vauthors = Wu Q, Maniatis T | title = A striking organization of a large family of human neural cadherin-like cell adhesion genes | journal = Cell | volume = 97 | issue = 6 | pages = 779–90 |date=Jul 1999 | pmid = 10380929 | doi =10.1016/S0092-8674(00)80789-8  | s2cid = 6014717 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PCDHB15 protocadherin beta 15| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56121}}</ref>
This gene is a member of the [[protocadherin]] beta gene cluster, one of three related gene clusters tandemly linked on [[chromosome five]]. The gene clusters demonstrate an unusual genomic organization similar to that of [[B-cell]] and [[T-cell]] receptor gene clusters. The beta cluster contains 16 genes and 3 [[pseudogenes]], each encoding 6 extracellular cadherin domains and a [[cytoplasmic]] tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a [[homophilic]] manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large [[exon]], not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral [[plasma membrane]] proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell [[neural]] connections.<ref name="entrez" />
==References==
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==Further reading==
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*{{cite journal  | vauthors=Nollet F, Kools P, van Roy F |title=Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 551–72 |year= 2000 |pmid= 10835267 |doi= 10.1006/jmbi.2000.3777 }}
*{{cite journal  | vauthors=Yagi T, Takeichi M |title=Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. |journal=Genes Dev. |volume=14 |issue= 10 |pages= 1169–80 |year= 2000 |pmid= 10817752 |doi=  10.1101/gad.14.10.1169|s2cid=44844497 |doi-access=free }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  | vauthors=Vanhalst K, Kools P, Vanden Eynde E, van Roy F |title=The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. |journal=FEBS Lett. |volume=495 |issue= 1–2 |pages= 120–5 |year= 2001 |pmid= 11322959 |doi=10.1016/S0014-5793(01)02372-9  |s2cid=36671435 |doi-access=free }}
*{{cite journal   |vauthors=Wu Q, Zhang T, Cheng JF, etal |title=Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. |journal=Genome Res. |volume=11 |issue= 3 |pages= 389–404 |year= 2001 |pmid= 11230163 |doi= 10.1101/gr.167301  | pmc=311048 }}
*{{cite journal  | vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397  | pmc=16203 |doi-access=free }}
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