View source for PDE4C

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''cAMP-specific 3',5'-cyclic phosphodiesterase 4C''' is an [[enzyme]] that in humans is encoded by the ''PDE4C'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5143| accessdate = }}</ref>
==Tissue localisation==
PDE4C is predominantly found in peripheral [[Tissue (biology)|tissues]].<ref>{{cite journal|title=Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs|journal=Current Pharmaceutical Design|date=2009|volume=15|issue=14|pages=1688–1698|doi=10.2174/138161209788168092|pmid=19442182|author=Zhang, HT}}</ref>
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Engels P, Sullivan M, Müller T, Lübbert H |title=Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C). |journal=FEBS Lett. |volume=358 |issue= 3 |pages= 305–10 |year= 1995 |pmid= 7843419 |doi=10.1016/0014-5793(94)01460-I  |s2cid=24276391 |doi-access=free }}
*{{cite journal  | vauthors=Milatovich A, Bolger G, Michaeli T, Francke U |title=Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. |journal=Somat. Cell Mol. Genet. |volume=20 |issue= 2 |pages= 75–86 |year= 1994 |pmid= 8009369 |doi=10.1007/BF02290677  |s2cid=19182571 }}
*{{cite journal   |vauthors=Bolger G, Michaeli T, Martins T, etal |title=A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs |journal=Mol. Cell. Biol. |volume=13 |issue= 10 |pages= 6558–71 |year= 1993 |pmid= 8413254 |doi=  10.1128/mcb.13.10.6558| pmc=364715  }}
*{{cite journal   |vauthors=Obernolte R, Ratzliff J, Baecker PA, etal |title=Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis |journal=Biochim. Biophys. Acta |volume=1353 |issue= 3 |pages= 287–97 |year= 1997 |pmid= 9349724 |doi=  10.1016/s0167-4781(97)00080-8}}
*{{cite journal   |vauthors=Owens RJ, Lumb S, Rees-Milton K, etal |title=Molecular cloning and expression of a human phosphodiesterase 4C |journal=Cell. Signal. |volume=9 |issue= 8 |pages= 575–85 |year= 1998 |pmid= 9429761 |doi=10.1016/S0898-6568(97)00072-7  }}
*{{cite journal  | vauthors=Sullivan M, Olsen AS, Houslay MD |title=Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND |journal=Cell. Signal. |volume=11 |issue= 10 |pages= 735–42 |year= 2000 |pmid= 10574328 |doi=10.1016/S0898-6568(99)00037-6  }}
*{{cite journal   |vauthors=Zauli G, Milani D, Mirandola P, etal |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com |doi-access=free |s2cid=26315564 }}
*{{cite journal   |vauthors=Pérez-Torres S, Miró X, Palacios JM, etal |title=Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain |journal=J. Chem. Neuroanat. |volume=20 |issue= 3–4 |pages= 349–74 |year= 2001 |pmid= 11207431 |doi=10.1016/S0891-0618(00)00097-1  |hdl=10261/112708 |s2cid=25012736 |hdl-access=free }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Johnson JM, Castle J, Garrett-Engele P, etal |title=Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays |journal=Science |volume=302 |issue= 5653 |pages= 2141–4 |year= 2004 |pmid= 14684825 |doi= 10.1126/science.1090100 |s2cid=10007258 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |doi-access= free }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}
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== External links ==
* {{PDBe-KB2|Q08493|cAMP-specific 3',5'-cyclic phosphodiesterase 4C}}
{{gene-19-stub}}