View source for PICALM

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{for|the anti-inflammatory ointment called Picalm|Piketoprofen}}
{{Infobox_gene}}
'''Phosphatidylinositol binding clathrin assembly protein''', also known as '''PICALM''', is a [[protein]] which in humans is encoded by the ''PICALM'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PICALM phosphatidylinositol binding clathrin assembly protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8301}}</ref>
== Interactions ==
PICALM has been shown to [[Protein-protein interaction|interact]] with [[CLTC]].<ref name=pmid10436022>{{cite journal |last=Tebar |first=F |author2=Bohlander S K |author3=Sorkin A  |date=Aug 1999 |title=Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic |journal=Mol. Biol. Cell |volume=10 |issue=8 |pages=2687–702 |location = UNITED STATES| issn = 1059-1524| pmid = 10436022 | url = http://diposit.ub.edu/dspace/bitstream/2445/25184/1/566402.pdf|pmc=25500 | doi=10.1091/mbc.10.8.2687}}</ref>
== Clinical significance ==
In humans, certain [[alleles]] of this gene have been statistically associated with an increased risk of developing late-onset [[Alzheimer's disease]].<ref name="pmid19734902">{{cite journal  |vauthors=Harold D, Abraham R, Hollingworth P, etal | title = Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | journal = Nat. Genet. | volume = 41| issue = 10| pages = 1088–93|date=September 2009 | pmid = 19734902 | doi = 10.1038/ng.440 | pmc = 2845877 }}
*{{cite magazine |author=Alice Park |date=2009-09-07 |title=Breakthrough Discoveries of Alzheimer's Genes |magazine=[[Time (magazine)|Time]] |url=http://www.time.com/time/health/article/0,8599,1920745,00.html |archive-url=https://web.archive.org/web/20090909142224/http://www.time.com/time/health/article/0,8599,1920745,00.html |archive-date=2009-09-09}}</ref>
== References ==
{{reflist}}
== Further reading ==
{{refbegin | 2}}
*{{cite journal |vauthors=Ron D, Habener JF |title=CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. |journal=Genes Dev. |volume=6 |issue= 3 |pages= 439–53 |year= 1992 |pmid= 1547942 |doi=10.1101/gad.6.3.439 |doi-access=free }}
*{{cite journal  |vauthors=Dreyling MH, Martinez-Climent JA, Zheng M, etal |title=The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 4804–9 |year= 1996 |pmid= 8643484 |doi= 10.1073/pnas.93.10.4804| pmc=39360 |bibcode=1996PNAS...93.4804D |doi-access=free }}
*{{cite journal  |vauthors=Silliman CC, McGavran L, Wei Q, etal |title=Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides. |journal=Leukemia |volume=12 |issue= 9 |pages= 1404–10 |year= 1998 |pmid= 9737689 |doi=10.1038/sj.leu.2401109 |doi-access=free }}
*{{cite journal |vauthors=Tebar F, Bohlander SK, Sorkin A |title=Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. |journal=Mol. Biol. Cell |volume=10 |issue= 8 |pages= 2687–702 |year= 1999 |pmid= 10436022 |doi= 10.1091/mbc.10.8.2687| pmc=25500 }}
*{{cite journal  |vauthors=Kim JA, Kim SR, Jung YK, etal |title=Properties of GST-CALM expressed in E. coli. |journal=Exp. Mol. Med. |volume=32 |issue= 2 |pages= 93–9 |year= 2000 |pmid= 10926122 |doi= 10.1038/emm.2000.17|s2cid=9913485 |doi-access=free }}
*{{cite journal  |vauthors=Wechsler DS, Engstrom LD, Alexander BM, etal |title=A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein. |journal=Genes Chromosomes Cancer |volume=36 |issue= 1 |pages= 26–36 |year= 2003 |pmid= 12461747 |doi= 10.1002/gcc.10136 |s2cid=6463540 |url= https://deepblue.lib.umich.edu/bitstream/2027.42/35133/1/10136_ftp.pdf |hdl= 2027.42/35133 |hdl-access= free }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal  |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |s2cid=27764390 }}
*{{cite journal  |vauthors=Park SY, Ha BG, Choi GH, etal |title=EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment. |journal=Biochemistry |volume=43 |issue= 23 |pages= 7552–62 |year= 2004 |pmid= 15182197 |doi= 10.1021/bi049970f }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  |vauthors=Meyerholz A, Hinrichsen L, Groos S, etal |title=Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation. |journal=Traffic |volume=6 |issue= 12 |pages= 1225–34 |year= 2006 |pmid= 16262731 |doi= 10.1111/j.1600-0854.2005.00355.x |s2cid=8040699 |doi-access=free }}
*{{cite journal |vauthors=Archangelo LF, Gläsner J, Krause A, Bohlander SK |title=The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10. |journal=Oncogene |volume=25 |issue= 29 |pages= 4099–109 |year= 2006 |pmid= 16491119 |doi= 10.1038/sj.onc.1209438 |doi-access= free }}
*{{cite journal  |vauthors=Deshpande AJ, Cusan M, Rawat VP, etal |title=Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. |journal=Cancer Cell |volume=10 |issue= 5 |pages= 363–74 |year= 2007 |pmid= 17097559 |doi= 10.1016/j.ccr.2006.08.023 |doi-access= free }}
*{{cite journal  |vauthors=Abdelhaleem M, Beimnet K, Kirby-Allen M, etal |title=High incidence of CALM-AF10 fusion and the identification of a novel fusion transcript in acute megakaryoblastic leukemia in children without Down's syndrome. |journal=Leukemia |volume=21 |issue= 2 |pages= 352–3 |year= 2007 |pmid= 17170719 |doi= 10.1038/sj.leu.2404503 |doi-access= free }}
*{{cite journal  |vauthors=Ashihara E, Nakamura S, Inaba T, etal |title=A novel AF10-CALM fusion transcript in gamma/delta-T cell type lymphoblastic lymphoma. |journal=Am. J. Hematol. |volume=82 |issue= 9 |pages= 859–60 |year= 2007 |pmid= 17597474 |doi= 10.1002/ajh.21021 |s2cid=72275219 |doi-access=free }}
*{{cite journal |vauthors=Caudell D, Zhang Z, Chung YJ, Aplan PD |title=Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice. |journal=Cancer Res. |volume=67 |issue= 17 |pages= 8022–31 |year= 2007 |pmid= 17804713 |doi= 10.1158/0008-5472.CAN-06-3749 | pmc=1986634 }}
{{refend}}
{{PDB Gallery|geneid=8301}}
{{gene-11-stub}}