View source for POLR2H

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{cs1 config|name-list-style=vanc}}
{{Infobox_gene}}
'''DNA-directed RNA polymerases I, II, and III subunit RPABC3''' is a [[protein]] that in humans is encoded by the ''POLR2H'' [[gene]].
This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III.<ref>{{cite web | title = Entrez Gene: POLR2H polymerase (RNA) II (DNA directed) polypeptide H| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5437}}</ref>
==Interactions==
POLR2H has been shown to [[Protein-protein interaction|interact]] with [[POLR2C]],<ref name=pmid9201987>{{cite journal |doi=10.1074/jbc.272.27.16815 |last=Acker |first=J |author2=de Graaff M |author3=Cheynel I |author4=Khazak V |author5=Kedinger C |author6=Vigneron M  |date=July 1997  |title=Interactions between the human RNA polymerase II subunits |journal=J. Biol. Chem. |volume=272 |issue=27 |pages=16815–21 |location = UNITED STATES| issn = 0021-9258| pmid = 9201987 |doi-access=free }}</ref> [[POLR2G]],<ref name=pmid9201987/> [[POLR2A]],<ref name=pmid9201987/> [[POLR2B]]<ref name=pmid9201987/> and [[POLR2E]].<ref name=pmid9201987/>
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  | author=Jeang KT |title=Tat, Tat-associated kinase, and transcription. |journal=J. Biomed. Sci. |volume=5 |issue= 1 |pages= 24–7 |year= 1998 |pmid= 9570510 |doi=10.1007/BF02253352  }}
*{{cite journal  |vauthors=Yankulov K, Bentley D |title=Transcriptional control: Tat cofactors and transcriptional elongation. |journal=Curr. Biol. |volume=8 |issue= 13 |pages= R447–9 |year= 1998 |pmid= 9651670 |doi=10.1016/S0960-9822(98)70289-1  |s2cid=15480646 |doi-access=free |bibcode=1998CBio....8.R447Y }}
*{{cite journal   |vauthors=Romano G, Kasten M, De Falco G, etal |title=Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression. |journal=J. Cell. Biochem. |volume=75 |issue= 3 |pages= 357–68 |year= 2000 |pmid= 10536359 |doi=10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K  |s2cid=43685090 }}
*{{cite journal  |vauthors=Marcello A, Zoppé M, Giacca M |title=Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. |journal=IUBMB Life |volume=51 |issue= 3 |pages= 175–81 |year= 2002 |pmid= 11547919 |doi=10.1080/152165401753544241  |s2cid=10931640 |doi-access=free }}
*{{cite journal  |vauthors=Stevens M, De Clercq E, Balzarini J |title=The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention. |journal=Med Res Rev |volume=26 |issue= 5 |pages= 595–625 |year= 2007 |pmid= 16838299 |doi= 10.1002/med.20081 |pmc= 7168390 }}
*{{cite journal   |vauthors=Harrich D, McMillan N, Munoz L, etal |title=Will diverse Tat interactions lead to novel antiretroviral drug targets? |journal=Current Drug Targets |volume=7 |issue= 12 |pages= 1595–606 |year= 2007 |pmid= 17168834 |doi=10.2174/138945006779025338  }}
*{{cite journal  |vauthors=Jang KL, Collins MK, Latchman DS |title=The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC. |journal=J. Acquir. Immune Defic. Syndr. |volume=5 |issue= 11 |pages= 1142–7 |year= 1992 |pmid= 1403646 }}
*{{cite journal   |vauthors=Kato H, Sumimoto H, Pognonec P, etal |title=HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors. |journal=Genes Dev. |volume=6 |issue= 4 |pages= 655–66 |year= 1992 |pmid= 1559613 |doi=10.1101/gad.6.4.655  |doi-access=free }}
*{{cite journal  |vauthors=Southgate C, Zapp ML, Green MR |title=Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein. |journal=Nature |volume=345 |issue= 6276 |pages= 640–2 |year= 1990 |pmid= 2190099 |doi= 10.1038/345640a0 |bibcode=1990Natur.345..640S |s2cid=4233742 }}
*{{cite journal  |vauthors=Freund E, McGuire PM |title=Characterization of RNA polymerase type II from human term placenta. |journal=J. Cell. Physiol. |volume=127 |issue= 3 |pages= 432–8 |year= 1986 |pmid= 3754875 |doi= 10.1002/jcp.1041270312 |s2cid=11708971 }}
*{{cite journal |author3-link=Richard Gaynor |vauthors=Wu-Baer F, Sigman D, Gaynor RB |title=Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 16 |pages= 7153–7 |year= 1995 |pmid= 7638159 |doi=10.1073/pnas.92.16.7153  | pmc=41297  |bibcode=1995PNAS...92.7153W |doi-access=free }}
*{{cite journal   |vauthors=Shpakovski GV, Acker J, Wintzerith M, etal |title=Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 4702–10 |year= 1995 |pmid= 7651387 |doi=  10.1128/mcb.15.9.4702| pmc=230713  }}
*{{cite journal  |vauthors=Herrmann CH, Rice AP |title=Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. |journal=J. Virol. |volume=69 |issue= 3 |pages= 1612–20 |year= 1995 |pmid= 7853496 |doi=  10.1128/JVI.69.3.1612-1620.1995| pmc=188757  }}
*{{cite journal  |vauthors=McKune K, Moore PA, Hull MW, Woychik NA |title=Six human RNA polymerase subunits functionally substitute for their yeast counterparts. |journal=Mol. Cell. Biol. |volume=15 |issue= 12 |pages= 6895–900 |year= 1996 |pmid= 8524256 |doi=  10.1128/mcb.15.12.6895| pmc=230944  }}
*{{cite journal  |vauthors=Keen NJ, Gait MJ, Karn J |title=Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 6 |pages= 2505–10 |year= 1996 |pmid= 8637904 |doi=10.1073/pnas.93.6.2505  | pmc=39827  |bibcode=1996PNAS...93.2505K |doi-access=free }}
*{{cite journal  |vauthors=Yang X, Herrmann CH, Rice AP |title=The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function. |journal=J. Virol. |volume=70 |issue= 7 |pages= 4576–84 |year= 1996 |pmid= 8676484 |doi=  10.1128/JVI.70.7.4576-4584.1996| pmc=190394  }}
*{{cite journal   |vauthors=Agostini I, Navarro JM, Rey F, etal |title=The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB. |journal=J. Mol. Biol. |volume=261 |issue= 5 |pages= 599–606 |year= 1996 |pmid= 8800208 |doi= 10.1006/jmbi.1996.0485 }}
*{{cite journal  |vauthors=Zhou Q, Sharp PA |title=Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. |journal=Science |volume=274 |issue= 5287 |pages= 605–10 |year= 1996 |pmid= 8849451 |doi=10.1126/science.274.5287.605  |bibcode=1996Sci...274..605Z |s2cid=13266489 }}
*{{cite journal   |vauthors=Okamoto H, Sheline CT, Corden JL, etal |title=Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 21 |pages= 11575–9 |year= 1996 |pmid= 8876177 |doi=10.1073/pnas.93.21.11575  | pmc=38099  |bibcode=1996PNAS...9311575O |doi-access=free }}
*{{cite journal  |vauthors=Chun RF, Jeang KT |title=Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27888–94 |year= 1996 |pmid= 8910388 |doi=10.1074/jbc.271.44.27888  |doi-access=free }}
{{refend}}
{{PDB Gallery|geneid=5437}}
{{gene-3-stub}}