View source for PRPF6

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Pre-mRNA-processing factor 6''' is a [[protein]] that in humans is encoded by the ''PRPF6'' [[gene]].<ref name="pmid10561546">{{cite journal |vauthors=Nishikimi A, Mukai J, Kioka N, Yamada M | title = A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors | journal = Biochim Biophys Acta | volume = 1435 | issue = 1–2 | pages = 147–52 |date=January 2000 | pmid = 10561546 | doi =  10.1016/s0167-4838(99)00203-4}}</ref><ref name="pmid10788320">{{cite journal |vauthors=Makarov EM, Makarova OV, Achsel T, Luhrmann R | title = The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions | journal = J Mol Biol | volume = 298 | issue = 4 | pages = 567–75 |date=June 2000 | pmid = 10788320 | doi = 10.1006/jmbi.2000.3685 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=24148}}</ref>
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.<ref name="entrez" />
==Interactions==
PRPF6 has been shown to [[Protein-protein interaction|interact]] with [[TXNL4B]],<ref name=pmid15161931>{{cite journal |last=Sun |first=Xiaojing |author2=Zhang Hua |author3=Wang Dan |author4=Ma Dalong |author5=Shen Yan |author6=Shang Yongfeng  |date=July 2004  |title=DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression |journal=J. Biol. Chem. |volume=279 |issue=31 |pages=32839–47 |location = United States| issn = 0021-9258| pmid = 15161931 |doi = 10.1074/jbc.M402522200 |doi-access=free }}</ref> [[ARAF]]<ref name=pmid12620389>{{cite journal |doi=10.1016/S0888-7543(02)00008-3 |last=Yuryev |first=Anton |author2=Wennogle Lawrence P  |date=February 2003  |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis |journal=Genomics |volume=81 |issue=2 |pages=112–25 |location = United States| issn = 0888-7543| pmid = 12620389 }}</ref><ref name=pmid10848612>{{cite journal |doi=10.1128/MCB.20.13.4870-4878.2000 |last=Yuryev |first=A |author2=Ono M |author3=Goff S A |author4=Macaluso F |author5=Wennogle L P  |date=July 2000  |title=Isoform-specific localization of A-RAF in mitochondria |journal=Mol. Cell. Biol. |volume=20 |issue=13 |pages=4870–8 |location = UNITED STATES| issn = 0270-7306| pmid = 10848612 |pmc=85938 }}</ref> and [[Androgen receptor]].<ref name=pmid12039962>{{cite journal |last=Zhao |first=Yue |author2=Goto Kiminobu |author3=Saitoh Masayuki |author4=Yanase Toshihiko |author5=Nomura Masatoshi |author6=Okabe Taijiro |author7=Takayanagi Ryoichi |author8=Nawata Hajime  |date=August 2002  |title=Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor |journal=J. Biol. Chem. |volume=277 |issue=33 |pages=30031–9 |location = United States| issn = 0021-9258| pmid = 12039962 |doi = 10.1074/jbc.M203811200 |doi-access=free }}</ref>
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal   |vauthors=Yuryev A, Ono M, Goff SA, etal |title=Isoform-specific localization of A-RAF in mitochondria. |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4870–8 |year= 2000 |pmid= 10848612 |doi=  10.1128/MCB.20.13.4870-4878.2000| pmc=85938  }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D |doi-access=free }}
*{{cite journal   |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=  10.1017/S1355838202021088| pmc=1370266  }}
*{{cite journal   |vauthors=Zhao Y, Goto K, Saitoh M, etal |title=Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30031–9 |year= 2002 |pmid= 12039962 |doi= 10.1074/jbc.M203811200 |doi-access= free }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  |vauthors=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112–25 |year= 2003 |pmid= 12620389 |doi=10.1016/S0888-7543(02)00008-3  }}
*{{cite journal   |vauthors=Goto K, Zhao Y, Saito M, etal |title=Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2–5 |pages= 201–8 |year= 2003 |pmid= 12943705 |doi=10.1016/S0960-0760(03)00196-1  |s2cid=46683850 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal   |vauthors=Will CL, Schneider C, Hossbach M, etal |title=The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. |journal=RNA |volume=10 |issue= 6 |pages= 929–41 |year= 2004 |pmid= 15146077 |doi=  10.1261/rna.7320604| pmc=1370585  }}
*{{cite journal   |vauthors=Sun X, Zhang H, Wang D, etal |title=DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression. |journal=J. Biol. Chem. |volume=279 |issue= 31 |pages= 32839–47 |year= 2004 |pmid= 15161931 |doi= 10.1074/jbc.M402522200 |doi-access= free }}
*{{cite journal   |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Laggerbauer B, Liu S, Makarov E, etal |title=The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation. |journal=RNA |volume=11 |issue= 5 |pages= 598–608 |year= 2005 |pmid= 15840814 |doi= 10.1261/rna.2300805  | pmc=1370748 }}
*{{cite journal  |vauthors=Batsché E, Yaniv M, Muchardt C |title=The human SWI/SNF subunit Brm is a regulator of alternative splicing. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 1 |pages= 22–9 |year= 2006 |pmid= 16341228 |doi= 10.1038/nsmb1030 |s2cid=11587161 }}
*{{cite journal   |vauthors=Fan S, Goto K, Chen G, etal |title=Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 1 |pages= 192–201 |year= 2006 |pmid= 16414017 |doi= 10.1016/j.bbrc.2005.12.167 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 }}
{{refend}}
==External links==
* [https://www.ncbi.nlm.nih.gov/books/NBK1417/  GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview]
{{Post transcriptional modification}}
[[Category:Spliceosome]]
{{protein-stub}}