View source for Pinin

{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{about|the PNN gene and protein}}
{{Infobox_gene}}
'''Pinin''' is a [[protein]] that in humans is encoded by the ''PNN'' [[gene]].<ref name="pmid8922384">{{cite journal |vauthors=Ouyang P, Sugrue SP | title = Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex | journal = J Cell Biol | volume = 135 | issue = 4 | pages = 1027–42 |date=January 1997 | pmid = 8922384 | pmc = 2133386 | doi =10.1083/jcb.135.4.1027  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PNN pinin, desmosome associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5411| accessdate = }}</ref>
==Interactions==
Pinin has been shown to [[Protein-protein interaction|interact]] with [[Keratin 8]],<ref name=pmid10809736>{{cite journal |doi=10.1074/jbc.275.20.14910 |last=Shi |first=J |author2=Sugrue S P  |date=May 2000 |title=Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus |journal=J. Biol. Chem. |volume=275 |issue=20 |pages=14910–5 | issn = 0021-9258| pmid = 10809736 |doi-access=free }}</ref> [[Keratin 18]],<ref name=pmid10809736/> [[Keratin 19]],<ref name=pmid10809736/> [[CTBP1]],<ref name=pmid15542832>{{cite journal |last=Alpatov |first=Roman |author2=Munguba Gustavo Costa |author3=Caton Paul |author4=Joo Jeong Hoon |author5=Shi Yang |author6=Shi Yujiang |author7=Hunt Marguerite E |author8=Sugrue Stephen P  |date=December 2004  |title=Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene |journal=Mol. Cell. Biol. |volume=24 |issue=23 |pages=10223–35 | issn = 0270-7306| pmid = 15542832 |doi = 10.1128/MCB.24.23.10223-10235.2004 |pmc=529029 }}</ref> [[RNPS1]],<ref name=pmid17353931>{{cite journal |last=Ewing |first=Rob M |author2=Chu Peter |author3=Elisma Fred |author4=Li Hongyan |author5=Taylor Paul |author6=Climie Shane |author7=McBroom-Cerajewski Linda |author8=Robinson Mark D |author9=O'Connor Liam |author10=Li Michael |author11=Taylor Rod |author12=Dharsee Moyez |author13=Ho Yuen |author14=Heilbut Adrian |author15=Moore Lynda |author16=Zhang Shudong |author17=Ornatsky Olga |author18=Bukhman Yury V |author19=Ethier Martin |author20=Sheng Yinglun |author21=Vasilescu Julian |author22=Abu-Farha Mohamed |author23=Lambert Jean-Philippe |author24=Duewel Henry S |author25=Stewart Ian I |author26=Kuehl Bonnie |author27=Hogue Kelly |author28=Colwill Karen |author29=Gladwish Katharine |author30=Muskat Brenda |author31=Kinach Robert |author32=Adams Sally-Lin |author33=Moran Michael F |author34=Morin Gregg B |author35=Topaloglou Thodoros |author36=Figeys Daniel |year=2007|title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages=89 | pmid = 17353931 |doi = 10.1038/msb4100134 |pmc=1847948 }}</ref><ref name=pmid14517304>{{cite journal |doi=10.1128/MCB.23.20.7363-7376.2003 |last=Li |first=Chin |author2=Lin Ru-Inn |author3=Lai Ming-Chih |author4=Ouyang Pin |author5=Tarn Woan-Yuh  |date=October 2003  |title=Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1 |journal=Mol. Cell. Biol. |volume=23 |issue=20 |pages=7363–76 | issn = 0270-7306| pmid = 14517304 |pmc=230327 }}</ref> [[PRPF4B]],<ref name=pmid12077342>{{cite journal |doi=10.1128/MCB.22.14.5141-5156.2002 |last=Dellaire |first=Graham |author2=Makarov Evgeny M |author3=Cowger Jeff J M |author4=Longman Dasa |author5=Sutherland Heidi G E |author6=Lührmann Reinhard |author7=Torchia Joseph |author8=Bickmore Wendy A  |date=July 2002  |title=Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes |journal=Mol. Cell. Biol. |volume=22 |issue=14 |pages=5141–56 | issn = 0270-7306| pmid = 12077342 |pmc=139773 }}</ref> [[SFRS4]],<ref name=pmid14578391>{{cite journal |doi=10.1167/iovs.03-0240 |last=Zimowska |first=Grazyna |author2=Shi Jia |author3=Munguba Gustavo |author4=Jackson Moira R |author5=Alpatov Roman |author6=Simmons Matthew N |author7=Shi Yujiang |author8=Sugrue Stephen P  |date=November 2003  |title=Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells |journal=Invest. Ophthalmol. Vis. Sci. |volume=44 |issue=11 |pages=4715–23 | issn = 0146-0404| pmid = 14578391 |doi-access=free }}</ref> [[PPIG (gene)|PPIG]],<ref name=pmid15358154>{{cite journal |last=Lin |first=Chun Lun |author2=Leu Steve |author3=Lu Ming Chu |author4=Ouyang Pin  |date=August 2004  |title=Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue=3 |pages=638–47 | issn = 0006-291X| pmid = 15358154 |doi = 10.1016/j.bbrc.2004.07.013 }}</ref> [[SRRM2]]<ref name=pmid14578391/> and [[SFRS18]].<ref name=pmid14578391/>
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  |vauthors=Brandner JM, Reidenbach S, Franke WW |title=Evidence that "pinin", reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein. |journal=Differentiation |volume=62 |issue= 3 |pages= 119–27 |year= 1998 |pmid= 9447706 |doi=10.1046/j.1432-0436.1997.6230119.x  }}
*{{cite journal   |vauthors=Degen WG, Agterbos MA, Muyrers JP, etal |title=memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell lines BLM and MV3. |journal=Biochim. Biophys. Acta |volume=1444 |issue= 3 |pages= 384–94 |year= 1999 |pmid= 10095061 |doi=  10.1016/s0167-4781(99)00012-3}}
*{{cite journal  | author=Ouyang P |title=Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein with dual location at the desmosome and within the nucleus. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 1 |pages= 192–200 |year= 1999 |pmid= 10486276 |doi= 10.1006/bbrc.1999.1353 }}
*{{cite journal  |vauthors=Shi Y, Ouyang P, Sugrue SP |title=Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function. |journal=Oncogene |volume=19 |issue= 2 |pages= 289–97 |year= 2000 |pmid= 10645008 |doi= 10.1038/sj.onc.1203328 |doi-access= free }}
*{{cite journal  |vauthors=Shi J, Sugrue SP |title=Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 14910–5 |year= 2000 |pmid= 10809736 |doi=10.1074/jbc.275.20.14910  |doi-access=free }}
*{{cite journal   |vauthors=Hu RM, Han ZG, Song HD, etal |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997  | pmc=16901 |bibcode=2000PNAS...97.9543H |doi-access=free }}
*{{cite journal   |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088  | pmc=1370266  }}
*{{cite journal  |vauthors=Wang P, Lou PJ, Leu S, Ouyang P |title=Modulation of alternative pre-mRNA splicing in vivo by pinin. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 2 |pages= 448–55 |year= 2002 |pmid= 12051732 |doi= 10.1016/S0006-291X(02)00495-3 }}
*{{cite journal   |vauthors=Dellaire G, Makarov EM, Cowger JJ, etal |title=Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. |journal=Mol. Cell. Biol. |volume=22 |issue= 14 |pages= 5141–56 |year= 2002 |pmid= 12077342 |doi=10.1128/MCB.22.14.5141-5156.2002  | pmc=139773  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Chang WL, Lee DC, Leu S, etal |title=Molecular characterization of a novel nucleolar protein, pNO40. |journal=Biochem. Biophys. Res. Commun. |volume=307 |issue= 3 |pages= 569–77 |year= 2003 |pmid= 12893261 |doi=10.1016/S0006-291X(03)01208-7  }}
*{{cite journal   |vauthors=Li C, Lin RI, Lai MC, etal |title=Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. |journal=Mol. Cell. Biol. |volume=23 |issue= 20 |pages= 7363–76 |year= 2003 |pmid= 14517304 |doi=10.1128/MCB.23.20.7363-7376.2003  | pmc=230327  }}
*{{cite journal   |vauthors=Zimowska G, Shi J, Munguba G, etal |title=Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. |journal=Invest. Ophthalmol. Vis. Sci. |volume=44 |issue= 11 |pages= 4715–23 |year= 2003 |pmid= 14578391 |doi=10.1167/iovs.03-0240  |doi-access=free }}
*{{cite journal   |vauthors=Sakashita E, Tatsumi S, Werner D, etal |title=Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1174–87 |year= 2004 |pmid= 14729963 |doi=10.1128/MCB.24.3.1174-1187.2004  | pmc=321435  }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}
*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |doi-access=free |bibcode=2004CBio...14.1436J }}
*{{cite journal  |vauthors=Lin CL, Leu S, Lu MC, Ouyang P |title=Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 3 |pages= 638–47 |year= 2004 |pmid= 15358154 |doi= 10.1016/j.bbrc.2004.07.013 }}
{{refend}}