View source for Proline-Rich Coiled Coil 1

{{short description|Protein}}
{{infobox_gene}}
'''Proline Rich Coiled Coil-1''' (PRCC1) is the commonly identified protein name of CAD38605. The PRCC1 gene is found on the long arm of [[Chromosome 5]]. It encodes for 445 [[Amino Acid|amino acids]] for a predicted total of 6 [[exon]]s.  The predicted [[molecular weight]] is 46.7 kDa, and the [[isoelectric point]] is 5.46.<ref>{{Cite journal|title = A Comparison of Bacterial Genomes|last = Kagachi|first = Chihiro|date = 2007|journal = Seikagaku- the Journal of Japanese Biochemical Society}}</ref> [[Homology (biology)#Orthology|Orthologs]] have been determined in most [[eukaryote]]s, the most highly conserved being found in most mammalian species. Moderate conservation is maintained among other distant species such as: ''[[Gallus gallus]]'', ''[[Xenopus]]'', ''[[Strongylocentrotus purpuratus]]'', ''[[Tetraodon]]'', etc.
The PRCC1 gene has two distinct regions: a [[proline]]-rich region on the [[N-terminus]], and the DUF84 region on the [[C-terminus]].
The DUF84 region is found in the genome of a bacterium called ''[[Vibrio cholerae]]''.<ref>{{cite web |url=https://www.ncbi.nlm.nih.gov/protein/15640721 |title=NTPase &#91;Vibrio cholerae O1 biovar El Tor str. N16961&#93; |publisher=[[National Center for Biotechnology Information]]}}</ref> The region consists of approximately 183 amino acid residues. V. cholerae causes [[cholera]] and [[stomach flu]] in humans. The DUF84 region alone is about 160 amino acid residues. It is the only other protein that consists of DUF84 other than PRCC1.
The subcellular localization prediction program pTarget, predicted PRCC1 to be localized in the [[cell nucleus|nucleus]] with a confidence of 95%.<ref>[http://bioapps.rit.albany.edu/pTARGET pTarget] {{webarchive|url=https://web.archive.org/web/20090627042705/http://bioapps.rit.albany.edu/pTARGET/ |date=2009-06-27 }}.</ref> However, a research paper by Kamakari et al. determined the protein to localize in the Golgi Apparatus.<ref name="paper">{{cite journal |vauthors=Kamakari S, Roussou A, Jefferson A, Ragoussis I, Anagnou NP |title=Structural analysis and expression profile of a novel gene on chromosome 5q23 encoding a Golgi-associated protein with six splice variants, and involved within the 5q deletion of a Ph(-) CML patient |journal=Leukemia Research |volume=29 |issue=1 |pages=17–31 |date=January 2005 |pmid=15541471 |doi=10.1016/j.leukres.2004.04.019}}</ref> PRCC1 is ubiquitously expressed, with high-density expression in the [[brain]], [[hypothalamus]] and [[hippocampus]] in particular. No evidence of protein-protein interactions were found. No evidence of RNA [[alternate splicing]] was determined.
==References==
{{reflist}}
==External links==
*[https://www.ncbi.nlm.nih.gov/protein/21732496 CAD38605]
*[https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01931&islf=1 DUF84]
[[Category:Proteins]]
[[Category:Genes on human chromosome 5]]