View source for S-(hydroxymethyl)glutathione synthase

{{infobox enzyme
| Name       = ''S''-(hydroxymethyl)glutathione synthase
| EC_number  = 4.4.1.22
| CAS_number =
| GO_code    = 0051907
| image      =
| width      =
| caption    =
}}
The enzyme '''''S''-(hydroxymethyl)glutathione synthase''' (EC 4.4.1.22) [[catalysis|catalyzes]] the reaction
:''S''-(hydroxymethyl)glutathione <math>\rightleftharpoons</math> glutathione + [[formaldehyde]]
This enzyme belongs to the family of [[lyase]]s, specifically the class of carbon-sulfur lyases.  The [[List of enzymes|systematic name]] of this enzyme class is '''''S''-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)'''. Other names in common use include '''glutathione-dependent formaldehyde-activating enzyme''', '''Gfa''', and '''''S''-(hydroxymethyl)glutathione formaldehyde-lyase'''.  This enzyme participates in methane metabolism.
== References ==
{{reflist|1}}
* {{cite journal | vauthors = Goenrich M, Bartoschek S, Hagemeier CH, Griesinger C, Vorholt JA | title = A glutathione-dependent formaldehyde-activating enzyme (Gfa) from ''Paracoccus denitrificans'' detected and purified via two-dimensional proton exchange NMR spectroscopy | journal = The Journal of Biological Chemistry | volume = 277 | issue = 5 | pages = 3069–72 | date = February 2002 | pmid = 11741920 | doi = 10.1074/jbc.C100579200 | authorlink5 = Julia Vorholt | doi-access = free | hdl = 11858/00-001M-0000-0012-F447-8 | hdl-access = free }}
{{Carbon-sulfur lyases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
[[Category:EC 4.4.1]]
[[Category:Enzymes of unknown structure]]
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