View source for SERPINA9

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Serpin A9''' also known as '''centerin''' or '''GCET1''' is a [[protein]] that in humans is encoded by the ''SERPINA9'' [[gene]] located on [[chromosome 14]]q32.1.<ref name="entrez">{{cite web | title = Entrez Gene: SERPINA9 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=327657}}</ref> Serpin A9 is a member of the [[serpin]] family of '''ser'''ine '''p'''rotease '''in'''hibitors.
== Function ==
The expression of SERPINA9 is restricted to [[germinal center]] [[B cell]]s and [[lymphoid leukemia|lymphoid malignancies]]. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.<ref name="pmid17447896">{{cite journal |vauthors=Paterson MA, Horvath AJ, Pike RN, Coughlin PB | title = Molecular characterization of centerin, a germinal centre cell serpin | journal = Biochem. J. | volume = 405 | issue = 3 | pages = 489–94 |date=August 2007 | pmid = 17447896 | pmc = 2267310 | doi = 10.1042/BJ20070174 }}</ref><ref name="pmid17898315">{{cite journal |vauthors=Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA | title = Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas | journal = Blood | volume = 111 | issue = 1 | pages = 351–8 |date=January 2008 | pmid = 17898315 | doi = 10.1182/blood-2007-06-094151 | doi-access = free }}</ref><ref name="pmid18550480">{{cite journal |vauthors=Paterson MA, Hosking PS, Coughlin PB | title = Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas | journal = Am. J. Clin. Pathol. | volume = 130 | issue = 1 | pages = 117–26 |date=July 2008 | pmid = 18550480 | doi = 10.1309/9QKE68QU7B825A3U | doi-access = free }}</ref>
==References==
{{Reflist|2}}
==Further reading==
{{refbegin | 2}}
*{{cite journal   |vauthors=Luke MM, O'Meara ES, Rowland CM, etal |title=Gene variants associated with ischemic stroke: the cardiovascular health study. |journal=Stroke |volume=40 |issue= 2 |pages= 363–8 |year= 2009 |pmid= 19023099  |pmc=2881155 |doi= 10.1161/STROKEAHA.108.521328 }}
*{{cite journal   |vauthors=Frazer JK, Jackson DG, Gaillard JP, etal |title=Identification of centerin: a novel human germinal center B cell-restricted serpin. |journal=Eur. J. Immunol. |volume=30 |issue= 10 |pages= 3039–48 |year= 2000 |pmid= 11069088 |doi= 10.1002/1521-4141(200010)30:10<3039::AID-IMMU3039>3.0.CO;2-H |doi-access= free }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334  |pmc=528928 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Morrison AC, Bare LA, Luke MM, etal |title=Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study. |journal=Cerebrovasc. Dis. |volume=26 |issue= 4 |pages= 420–4 |year= 2008 |pmid= 18799872  |pmc=2662496 |doi= 10.1159/000155637 }}
*{{cite journal   |vauthors=Shiffman D, O'Meara ES, Bare LA, etal |title=Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=28 |issue= 1 |pages= 173–9 |year= 2008 |pmid= 17975119  |pmc=2636623 |doi= 10.1161/ATVBAHA.107.153981 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309  |pmc=403697 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932  |pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Montes-Moreno S, Roncador G, Maestre L, etal |title=Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas. |journal=Blood |volume=111 |issue= 1 |pages= 351–8 |year= 2008 |pmid= 17898315 |doi= 10.1182/blood-2007-06-094151 |doi-access= free }}
*{{cite journal   |vauthors=Pan Z, Shen Y, Du C, etal |title=Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells. |journal=Am. J. Pathol. |volume=163 |issue= 1 |pages= 135–44 |year= 2003 |pmid= 12819018  |pmc=1868163 |doi=10.1016/S0002-9440(10)63637-1  }}
*{{cite journal   |vauthors=Namciu SJ, Friedman RD, Marsden MD, etal |title=Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1 |journal=Mamm. Genome |volume=15 |issue= 3 |pages= 162–78 |year= 2004 |pmid= 15014966 |doi= 10.1007/s00335-003-2311-y |s2cid=8594824 }}
{{refend}}
== External links ==
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I04.082 I04.082]
* {{MeshName|SERPINA9+protein,+human}}
{{Serpins}}
[[Category:Serine protease inhibitors]]
{{gene-14-stub}}