View source for SPPL2B

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Signal peptide peptidase-like 2B''', also known as '''SPPL2B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SPPL2B signal peptide peptidase-like 2B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56928| accessdate = }}</ref>
This gene is a member of the [[signal peptide peptidase]]-like protease (SPPL) family with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This enzyme localizes to endosomes, lysosomes, and the plasma membrane. This protein plays a role in innate and adaptive immunity by cleaving [[TNFα]] in activated [[dendritic cells]].<ref>{{cite journal  |vauthors=Friedmann E, Hauben E, Maylandt K, etal |title=SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production |journal=Nat. Cell Biol. |volume=8 |issue=8 |pages=843–8 |year=2006 |pmid=16829952 |doi=10.1038/ncb1440|s2cid=129089 }}</ref><ref>{{cite journal  |vauthors=Fluhrer R, Grammer G, Israel L, etal |title=A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b |journal=Nat. Cell Biol. |volume=8 |issue=8 |pages=894–6 |year=2006 |pmid=16829951 |doi=10.1038/ncb1450|s2cid=23712486 |url=https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/51830 }}</ref> SPPL2b also modulates APP cleavage and Aβ production.<ref>{{Cite journal |last=Maccioni |first=Riccardo |last2=Travisan |first2=Caterina |last3=Badman |first3=Jack |last4=Zerial |first4=Stefania |last5=Wagener |first5=Annika |last6=Andrade-Talavera |first6=Yuniesky |last7=Picciau |first7=Federico |last8=Grassi |first8=Caterina |last9=Chen |first9=Gefei |last10=Lemoine |first10=Laetitia |last11=Fisahn |first11=André |last12=Jiang |first12=Richeng |last13=Fluhrer |first13=Regina |last14=Mentrup |first14=Torben |last15=Schröder |first15=Bernd |date=April 2024 |title=Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease |url=https://linkinghub.elsevier.com/retrieve/pii/S0301008224000212 |journal=Progress in Neurobiology |language=en |volume=235 |pages=102585 |doi=10.1016/j.pneurobio.2024.102585|doi-access=free }}</ref> Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SPPL2B signal peptide peptidase-like 2B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56928| accessdate = }}</ref>
==References==
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==Further reading==
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*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  |doi-access=free }}
*{{cite journal   |vauthors=Nagase T, Kikuno R, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=10.1093/dnares/7.2.143  |doi-access=free }}
*{{cite journal   |vauthors=Weihofen A, Binns K, Lemberg MK, etal |title=Identification of signal peptide peptidase, a presenilin-type aspartic protease. |journal=Science |volume=296 |issue= 5576 |pages= 2215–8 |year= 2002 |pmid= 12077416 |doi= 10.1126/science.1070925 |bibcode=2002Sci...296.2215W |s2cid=45633906 }}
*{{cite journal  | vauthors=Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI |title=Novel class of polytopic proteins with domains associated with putative protease activity. |journal=Biochemistry Mosc. |volume=67 |issue= 7 |pages= 826–35 |year= 2003 |pmid= 12139484 |doi=10.1023/A:1016365227942  |s2cid=11785597 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |s2cid=4420825 |url= https://digital.library.unt.edu/ark:/67531/metadc1408307/m2/1/high_res_d/15014060.pdf |doi-access= free }}
*{{cite journal   |vauthors=Friedmann E, Lemberg MK, Weihofen A, etal |title=Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 50790–8 |year= 2005 |pmid= 15385547 |doi= 10.1074/jbc.M407898200 |doi-access= free |hdl= 2262/89311 |hdl-access= free }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Krawitz P, Haffner C, Fluhrer R, etal |title=Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39515–23 |year= 2006 |pmid= 15998642 |doi= 10.1074/jbc.M501645200 |doi-access= free }}
*{{cite journal   |vauthors=Fluhrer R, Grammer G, Israel L, etal |title=A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. |journal=Nat. Cell Biol. |volume=8 |issue= 8 |pages= 894–6 |year= 2006 |pmid= 16829951 |doi= 10.1038/ncb1450 |s2cid=23712486 |url= https://escholarship.org/content/qt59c2q1jk/qt59c2q1jk.pdf?t=ntc2ir }}
*{{cite journal   |vauthors=Friedmann E, Hauben E, Maylandt K, etal |title=SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. |journal=Nat. Cell Biol. |volume=8 |issue= 8 |pages= 843–8 |year= 2006 |pmid= 16829952 |doi= 10.1038/ncb1440 |s2cid=129089 }}
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